Compounds having triple activities of thrombolysis, antithrombosis, and radical scavenging, synthesis, and use thereof
The present invention relates to a compound simultaneously having triple activities of thrombolysis, antithrombosis and free radical scavenging, as well as the preparation method, composition, and applications thereof. The compound is represented by the formula I shown below: wherein the definitions of T, Q, R 1 and R 2 are described herein. The compound of the present invention simultaneously has triple functions of thrombolysis, free radical scavenging and thrombus-targeting/antithrombosis. The present invention also relates to a pharmaceutical composition comprising the compound, and a preparation method and a nanostructure of the compound.
1. A compound having the following formula of Ia:
wherein AA is selected from the group consisting of L-Ala, L-Val, L-Trp, L-Tyr, L-Pro, L-Phe, Gly, L-Ser, L-Ile, L-Thr, L-Lys, L-Leu, L-Gln, L-Asn, L-Asp, and L-Glu.
2. The compound of claim 1 , wherein AA is L-Lys.
3. A pharmaceutical composition, comprising the compound of claim 1 , and a pharmaceutically acceptable carrier.
4. The pharmaceutical composition of claim 3 , wherein the compound is in the form of a nanospherical structure.
5. A method for performing thrombolysis, NO free radical scavenging or antithrombotic therapy in a subject in need thereof, the method comprising administering to the subject a pharmaceutically effective amount of the pharmaceutical composition of claim 3 .
6. A method of treating stroke or cerebral infarction, the method comprising administering to a subject in need thereof a pharmaceutically effective amount of the pharmaceutical composition of claim 3 .