IP Library › Granted Patent US 9,902,702

Granted Patent B2

US 9,902,702 · App. 14/797,414 · Granted Feb 27, 2018

Spirocycloheptanes as inhibitors of rock

Inventors: Vladimir Ladziata (Ewing, NJ); Peter W. Glunz (Yardley, PA); Zilun Hu (Jamison, PA); Yufeng Wang (North Brunswick, NJ)

Assignee: Bristol-Myers Squibb Company

C07D237/32 C07D403/08 C07D403/12 C07D405/14 C07D413/12 C07D413/14 C07D417/12 C07D417/14 C07D471/04 C07D471/10 C07D487/04 C07D513/04 C07D519/00

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Quick Facts

Patent No.: US 9,902,702
App. No.: 14/797,414
Granted: Feb 27, 2018
Kind: B2

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Abstract

The present invention provides compounds of Formula (I): or stereoisomers, tautomers, or pharmaceutically-acceptable salts thereof, wherein all the variables are as defined herein. These compounds are selective ROCK inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating cardiovascular, smooth muscle, oncologic, neuropathologic, autoimmune, fibrotic, and/or inflammatory disorders using the same.

Claims (740)

1. A compound of Formula (I):

or a stereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:

Ring A is a 5- to 9-membered bicyclic spiro carbocycle;

is selected from

M is absent or selected from N and CR 10 ;

L is selected from —(CR 4 R 4 ) 0-1 —, —(CR 4 R 4 ) 0-1 C(O)—, —OC(O)—, —NR 6 C(O)—, and —NR 6 —;

R 1 is selected from NR 5 R 5 , OR 5 , —(CR 4 R 4 ) n C 3-10 carbocycle and —(CR 4 R 4 ) n -4- to 15-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p ; wherein said carbocycle, and heterocycle are substituted with 1-4 R 7 ;

R 2 , at each occurrence, is independently selected from halogen, C 1-6 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 haloalkyl, —OH, —CH 2 OH, —OCH 2 F, —OCHF 2 , —OCF 3 , CN, —NH 2 , —NH(C 1-4 alkyl), —N(C 1-4 alkyl) 2 , —CO 2 H, —CH 2 CO 2 H, —CO 2 (C 1-4 alkyl), —CO(C 1-4 alkyl), —CH 2 NH 2 , —CONH 2 , —CONH(C 1-4 alkyl), —CON(C 1-4 alkyl) 2 , —OCH 2 CO 2 H, —NHCO(C 1-4 alkyl), —NHCO 2 (C 1-4 alkyl), —NHSO 2 (C 1-4 alkyl), —SO 2 NH 2 , —C(═NH)NH 2 , a carbocycle, and a heterocycle, wherein said alkyl, alkoxy, alkylthio, haloalkyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

R 3 , at each occurrence, is independently selected from halogen, C 1-6 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 haloalkyl, —CH 2 OH, —OCH 2 F, —OCHF 2 , —OCF 3 , CN, —NH 2 , —NH(C 1-4 alkyl), —N(C 1-4 alkyl) 2 , —CO 2 H, —CH 2 CO 2 H, —CO 2 (C 1-4 alkyl), —CO(C 1-4 alkyl), —CH 2 NH 2 , —CONH 2 , —CONH(C 1-4 alkyl), —CON(C 1-4 alkyl) 2 , —OCH 2 CO 2 H, —NHCO(C 1-4 alkyl), —NHCO 2 (C 1-4 alkyl), —NHSO 2 (C 1-4 alkyl), —SO 2 NH 2 , —C(═NH)NH 2 , a carbocycle, and a heterocycle, wherein said alkyl, alkoxy, alkylthio, haloalkyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

R 4 , at each occurrence, is independently selected from H, OH, NH 2 , CH 2 NH 2 , C 1-4 haloalkyl, OCH 2 F, OCHF 2 , OCF 3 , —NH(C 1-4 alkyl), —N(C 1-4 alkyl) 2 , C 1-4 alkoxy, CH 2 OH, CH 2 O(C 1-4 alkyl), CH 2 CO 2 H, CH 2 CO 2 (C 1-4 alkyl), C 1-4 alkyl, a carbocycle, and a heterocycle, wherein said alkyl, alkoxy, haloalkyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

R 5 , at each occurrence, is independently selected from H, C 1-4 alkyl, —(CR 6 R 6 ) n —C 3-10 carbocycle and —(CR 6 R 6 ) n -4- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, carbocycle and heterocycle are substituted with 1-4 R 7 ;

alternatively, R 5 and R 5 are taken together with the nitrogen atom to which they are attached to form a 4- to 15-membered substituted with 1-4 R 7 ;

R 6 , at each occurrence, is independently selected from H, C 1-4 alkyl, CH 2 NH 2 , C 1-4 haloalkyl, C 1-4 alkoxy, CH 2 OH, CH 2 O(C 1-4 alkyl), CH 2 CO 2 H, CH 2 CO 2 (C 1-4 alkyl), a carbocycle, and a heterocycle, wherein said alkyl, alkoxy, haloalkyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

alternatively, R 1 and R 6 are taken together with the nitrogen atom to which they are attached to form a heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p and substituted with 1-4 R;

R 7 , at each occurrence, is independently selected from H, ═O, NO 2 , halogen, C 1-7 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkoxy, CN, OH, CHF 2 , CF 3 , —(CH 2 ) n —CO 2 H, —(CH 2 ) n —CO 2 (C 1-4 alkyl), —(CH 2 ) n —NR 8 R 8 , —NHCOH, —NHCO(C 1-4 alkyl), —NHCOCF 3 , —NHCO 2 (C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 3 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 OH, —NHCO 2 (CH 2 ) 2 NH 2 , —NHCO 2 (CH 2 ) 2 N(C 1-4 alkyl) 2 , —NHCO 2 CH 2 CO 2 H, —CH 2 NHCO 2 (C 1-4 alkyl), —NHC(O)NR 8 R 8 , —NHSO 2 (C 1-4 alkyl), —S(O) p (C 1-4 alkyl), —SO 2 NH 2 , —SO 2 NH(C 1-4 alkyl), —SO 2 N(C 1-4 alkyl) 2 , —SO 2 NH(CH 2 ) 2 OH, —SO 2 NH(CH 2 ) 2 O(C 1-4 alkyl), —(CH 2 ) n —CONR 8 R 8 , —O(CH 2 ) n -carbocycle, —O(CH 2 ) n -heterocycle, —NHCO-carbocycle, —NHCO-heterocycle, —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, alkenyl, alkynyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

R 8 , at each occurrence, is independently selected from H, C 1-6 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, —(CH 2 ) n —C(O)C 1-4 alkyl, —(CH 2 ) n —C(O)carbocycle, —(CH 2 ) n —C(O)heterocycle, —(CH 2 ) n —C(O)NR a R a , —(CH 2 ) n —NR a C(O) C 1-4 alkyl, —(CH 2 ) n —C(O)OC 1-4 alkyl, —(CH 2 ) n —C(O)C 1-4 alkyl, —(CH 2 ) n —C(O)O-carbocycle, —(CH 2 ) n —C(O)O-heterocycle, —(CH 2 ) n —SO 2 alkyl, —(CH 2 ) n —SO 2 carbocycle, —(CH 2 ) n —SO 2 heterocycle, —(CH 2 ) n —SO 2 NR a R a , —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle, wherein said alkyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

alternatively, R 8 and R 8 are taken together with the nitrogen atom to which they are attached to form a 4- to 10-membered heterocycle substituted with 0-4 R 9 ;

R 9 , at each occurrence, is independently selected from halogen, OH, ═O, CN, NO 2 , CHF 2 , CF 3 , C 1-4 alkyl, C 1-4 alkoxy, CH 2 OH, CO(C 1-4 alkyl), CO 2 H, CO 2 (C 1-4 alkyl), —(CHR 10 ) n NR a R a , —(CHR 10 ) n CONR a R a , —(CHR 10 ) n NR a CO(C 1-4 alkyl), —O(CHR 10 ) n carbocycle, —O(CHR 10 ) n heterocycle, —O(CHR 10 ) n NR a R a , and —(CR 10 R 10 ) n -4- to 10-membered heterocycle, wherein said alkyl, alkoxy, carbocycle, and heterocycle are substituted with 0-4 R b ;

R 10 is selected from H and C 1-4 alkyl;

R a , at each occurrence, is independently selected from H, C 1-4 alkyl, —(CH 2 ) n OH, CO(C 1-4 alkyl), COCF 3 , CO 2 (C 1-4 alkyl), —CONH 2 , —CONH—C 1-4 alkylene-CO 2 (C 1-4 alkyl), C 1-4 alkylene-CO 2 (C 1-4 alkyl), R c , CO 2 R c , and CONHR c ; alternatively, R a and R a are taken together with the nitrogen atom to which they are attached to form a 4- to 10-membered heterocycle, wherein said alkyl, alkylene, and heterocycle are substituted with 0-4 R b ;

R b , at each occurrence, is independently selected from ═O, OH, halogen, C 1-4 alkyl, C 1-4 alkoxy, OCF 3 , OC(O)C 1-4 alkyl, NH 2 , NO 2 , N(C 1-4 alkyl) 2 , CO(C 1-4 alkyl), CO(C 1-4 haloalkyl), CO 2 (C 1-4 alkyl), CONH 2 , —CONH(C 1-4 alkyl), —CON(C 1-4 alkyl) 2 , —CONH—C 1-4 alkylene-O(C 1-4 alkyl), —CONH—C 1-4 alkylene-N(C 1-4 alkyl) 2 , —C 1-4 alkylene-O—P(O)(OH) 2 , —NHCO 2 (C 1-4 alkyl), —R c , COR c , CO 2 R c , and CONHR c , wherein said alkyl and alkoxy are substituted with R d ;

R c , at each occurrence, is independently selected from —(CH 2 ) n —C 3-6 cycloalkyl, —(CH 2 ) n -phenyl, and —(CH 2 ) n -5- to 6-membered heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of: N, NH, N(C 1-4 alkyl), O, and S(O) p ; wherein each ring moiety is substituted with 0-2 R d ;

R d , at each occurrence, is independently selected from ═O, halogen, —OH, C 1-4 alkyl, NH 2 , NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , C 1-4 alkoxy, and —NHCO(C 1-4 alkyl), and a heterocycle containing carbon atoms and 1-4 heteroatoms selected from the group consisting of: N, NH, N(C 1-4 alkyl), O, and S(O) p ;

n, at each occurrence, is independently selected from 0, 1, 2, 3, and 4; and

p, at each occurrence, is independently selected from 0, 1, and 2.

2. The compound of claim 1 , having Formula (II):

or a stereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:

is selected from

M is selected from N and CR 10 ;

L is selected from —(CR 4 R 4 ) 0-1 —, —(CR 4 R 4 ) 0-1 C(O)—, —OC(O)—, —NR 6 C(O)—, and —NR 6 —;

alternatively, R 5 and R 5 are taken together with the nitrogen atom to which they are attached to form a 4- to 15-membered heterocycle substituted with 1-4 R 7 ;

R 7 , at each occurrence, is independently selected from H, ═O, NO 2 , halogen, C 1-6 alkyl, C 2-4 alkenyl, C 1-4 alkoxy, CN, OH, CF 3 , —(CH 2 ) n —CO 2 H, —(CH 2 ) n —CO 2 (C 1-4 alkyl), —(CH 2 ) n —NR 8 R 8 , —NHCOH, —NHCO(C 1-4 alkyl), —NHCOCF 3 , —NHCO 2 (C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 3 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 OH, —NHCO 2 (CH 2 ) 2 NH 2 , —NHCO 2 (CH 2 ) 2 N(C 1-4 alkyl) 2 , —NHCO 2 CH 2 CO 2 H, —CH 2 NHCO 2 (C 1-4 alkyl), —NHC(O)NR 8 R 8 , —NHSO 2 (C 1-4 alkyl), —S(O) p (C 1-4 alkyl), —SO 2 NH 2 , —SO 2 NH(C 1-4 alkyl), —SO 2 N(C 1-4 alkyl) 2 , —SO 2 NH(CH 2 ) 2 OH, —SO 2 NH(CH 2 ) 2 O(C 1-4 alkyl), —(CH 2 ) n —CONR 8 R 8 , —O(CH 2 ) n -carbocycle, —O(CH 2 ) n -heterocycle, —NHCO-carbocycle, —NHCO-heterocycle, —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, alkenyl, alkoxyl, a carbocycle, and a heterocycle are substituted with 0-4 R 9 ;

R 8 , at each occurrence, is independently selected from H, C 1-4 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, —(CH 2 ) n —C(O)C 1-4 alkyl, —(CH 2 ) n —C(O)carbocycle, —(CH 2 ) n —C(O)heterocycle, —(CH 2 ) n —C(O)NR a R a , —(CH 2 ) n —NR a C(O)C 1-4 alkyl, —(CH 2 ) n —C(O)OC 1-4 alkyl, —(CH 2 ) n —C(O)C 1-4 alkyl, —(CH 2 ) n —C(O)O-carbocycle, —(CH 2 ) n —C(O)O-heterocycle, —(CH 2 ) n —SO 2 alkyl, —(CH 2 ) n SO 2 carbocycle, —(CH 2 ) n —SO 2 heterocycle, —(CH 2 ) n —SO 2 NR a R a , —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle, wherein said alkyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

alternatively, R 8 and R 8 are taken together with the nitrogen atom to which they are attached to form a 4- to 10-membered heterocycle substituted with 0-4 R 9 ;

R 10 is selected from H and C 1-4 alkyl;

n, at each occurrence, is independently selected from 0, 1, 2, 3, and 4; and

p, at each occurrence, is independently selected from 0, 1, and 2.

3. The compound of claim 2 , having Formula (III):

or a stereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:

M is selected from N and CR 10 ;

R 1 is selected from NR 5 R 5 , OR 5 , —(CH 2 ) n —C3-10 carbocycle, and —(CH 2 ) n -5- to 15-membered heterocycle, wherein said carbocycle and heterocycle are substituted with 1-4 R 7 ;

R 3 , at each occurrence, is independently selected from halogen, C 1-6 alkyl, C 1-4 alkoxy, C 1-4 alkylthio, C 1-4 haloalkyl, —CH 2 OH, —OCH 2 F, —OCHF 2 , —OCF 3 , CN, and —NH 2 ;

R 5 , at each occurrence, is independently selected from H, C 1-4 alkyl, —(CR 6 R 6 ) n —C 3-10 carbocycle, and —(CR 6 R 6 ) n -4- to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, carbocycle, and heterocycle are substituted with 1-4 R;

alternatively, R 5 and R 5 are taken together with the nitrogen atom to which they are attached to form a 4- to 10-membered heterocycle substituted with 1-4 R;

R 6 , at each occurrence, is independently selected from H and C1-4 alkyl;

R 7 , at each occurrence, is independently selected from H, ═O, NO 2 , halogen, C 1-6 alkyl, C 1-4 alkoxy, CN, OH, CF 3 , —(CH 2 ) n —CO 2 H, —(CH 2 ) n —CO 2 (C 1-4 alkyl), —(CH 2 ) n —NR 8 R 8 , —NHCOH, —NHCO(C 1-4 alkyl), —NHCOCF 3 , —NHCO 2 (C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 3 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 OH, —NHCO 2 (CH 2 ) 2 NH 2 , —NHCO 2 (CH 2 ) 2 N(C 1-4 alkyl) 2 , —NHCO 2 CH 2 CO 2 H, —CH 2 NHCO 2 (C 1-4 alkyl), —NHC(O)NR 8 R 8 , —NHSO 2 (C 1-4 alkyl), —S(O) p (C 1-4 alkyl), —SO 2 NH 2 , —SO 2 NH(C 1-4 alkyl), —SO 2 N(C 1-4 alkyl) 2 , —SO 2 NH(CH 2 ) 2 OH, —SO 2 NH(CH 2 ) 2 O(C 1-4 alkyl), —(CH 2 ) n —CONR 8 R 8 , —O(CH 2 ) n -carbocycle, —O(CH 2 ) n -heterocycle, —NHCO-carbocycle, —NHCO-heterocycle, —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, alkenyl, alkynyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

R 8 , at each occurrence, is independently selected from H, C 1-4 alkyl, C 2-4 alkenyl, C(O)C 1-4 alkyl, C(O)carbocycle, C(O)heterocycle, —(CH 2 ) n —C(O)NR a R a , —(CH 2 ) n —NR a C(O)C 1-4 alkyl, C(O)OC 1-4 alkyl, C(O)O-carbocycle, C(O)O-heterocycle, SO 2 alkyl, SO 2 carbocycle, SO 2 heterocycle, SO 2 NR a R a , —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle, wherein said alkyl, alkenyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

alternatively, R 8 and R 8 are taken together with the nitrogen atom to which they are attached to form a 4- to 10-membered heterocycle substituted with 0-4 R 9 ;

R 9 , at each occurrence, is independently selected from halogen, OH, CN, NO 2 , CHF 2 , CF 3 , C 1-4 alkyl, C 1-4 alkoxy, CH 2 OH, CO(C 1-4 alkyl), CO 2 H, CO 2 (C 1-4 alkyl), —(CHR 10 ) n NR a R a , —(CHR 10 ) n CONR a R a , —(CHR 10 ) n NR a CO(C 1-4 alkyl), —O(CHR 10 ) n carbocycle, —O(CHR 10 ) n heterocycle, —O(CHR 10 ) n NR a R a , and —(CR 10 R 10 ) n -4- to 10-membered heterocycle, wherein said alkyl, alkoxy, carbocycle, and heterocycle are substituted with 0-4 R b ;

R 10 is selected from H and C1-4 alkyl;

R b , at each occurrence, is independently selected from ═O, halogen, C 1-4 alkyl, C 1-4 alkoxy, OCF 3 , OC(O)C 1-4 alkyl, NH 2 , NO 2 , N(C 1-4 alkyl) 2 , CO(C 1-4 alkyl), CO(C 1-4 haloalkyl), CO 2 (C 1-4 alkyl), CONH 2 , —CONH(C 1-4 alkyl), —CON(C 1-4 alkyl) 2 , —CONH—C 1-4 alkylene-O(C 1-4 alkyl), —CONH—C 1-4 alkylene-N(C 1-4 alkyl) 2 , —C 1-4 alkylene-O—P(O)(OH) 2 , —NHCO 2 (C 1-4 alkyl), —R c , COR c , CO 2 R c , and CONHR c , wherein said alkyl and alkoxy are substituted with R d ;

n, at each occurrence, is independently selected from 0, 1, 2, 3, and 4; and

p, at each occurrence, is independently selected from 0, 1, and 2.

4. The compound of claim 3 or a stereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:

R 1 is NR 5 R 5 ;

R 5 and R 5 are taken together with the nitrogen atom to which they are attached to form a 4- to 10-membered heterocycle substituted with 1-4 R 7 ;

R 7 , at each occurrence, is independently selected from H, halogen, C 1-4 alkyl, C 1-4 alkoxy, CN, OH, CF 3 , and —NR 8 R 8 ; and

R 8 , at each occurrence, is independently selected from H and C 1-4 alkyl.

5. The compound of claim 1 , having Formula (V):

or a stereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:

M is selected from N and CR 10 ;

R 1 is a 5- to 10-membered heterocycle substituted with 1-4 R 7 ;

R 6 , at each occurrence, is independently selected from H and C1-4 alkyl;

R 7 , at each occurrence, is independently selected from H, ═O, NO 2 , halogen, C 1-4 alkyl, C 1-4 alkoxy, CN, OH, CF 3 , —(CH 2 ) n —CO 2 H, —(CH 2 ) n —CO 2 (C 1-4 alkyl), —(CH 2 ) n —NR 8 R 8 , —NHCO(C 1-4 alkyl), —NHCOCF 3 , —NHCO 2 (C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 3 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 OH, —NHCO 2 (CH 2 ) 2 NH 2 , —NHCO 2 (CH 2 ) 2 N(C 1-4 alkyl) 2 , —NHCO 2 CH 2 CO 2 H, —CH 2 NHCO 2 (C 1-4 alkyl), —NHC(O)NR 8 R 8 , —NHSO 2 (C 1-4 alkyl), —SO 2 NH 2 , —SO 2 NH(C 1-4 alkyl), —SO 2 N(C 1-4 alkyl) 2 , —SO 2 NH(CH 2 ) 2 OH, —SO 2 NH(CH 2 ) 2 O(C 1-4 alkyl), —(CH 2 ) n —CONR 8 R 8 , —O(CH 2 ) n -carbocycle, —O(CH 2 ) n -heterocycle, —NHCO-carbocycle, —NHCO-heterocycle, —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, alkenyl, alkynyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

R 8 , at each occurrence, is independently selected from H, C 1-4 alkyl, —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle, wherein said alkyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

R 10 is selected from H and C 1-4 alkyl;

R b , at each occurrence, is independently selected from ═O, halogen, C 1-4 alkyl, C 1-4 alkoxy, OCF 3 , NH 2 , NO 2 , N(C 1-4 alkyl) 2 , CO(C 1-4 alkyl), CO(C 1-4 haloalkyl), CO 2 (C 1-4 alkyl), CONH 2 , —CONH(C 1-4 alkyl), —CON(C 1-4 alkyl) 2 , —CONH—C 1-4 alkylene-O(C 1-4 alkyl), —CONH—C 1-4 alkylene-N(C 1-4 alkyl) 2 , —C 1-4 alkylene-O—P(O)(OH) 2 , —NHCO 2 (C 1-4 alkyl), —R c , COR c , CO 2 R c , and CONHR c ;

n, at each occurrence, is independently selected from 0, 1, 2, 3, and 4; and

p, at each occurrence, is independently selected from 0, 1, and 2.

6. The compound of claim 5 , having Formula (VI):

or a stereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:

R 1 is selected from

R 6 is H; and

R 7 , at each occurrence, is independently selected from H, halogen, C 1-4 alkyl, C 1-4 alkoxy, CN, OH, —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle, wherein said alkyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 R 9 .

7. The compound of claim 1 , having Formula (VII):

or a stereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:

M is selected from N and CR 10 ;

R 5 , at each occurrence, is independently selected from H, C 1-4 alkyl, —(CR 6 R 6 ) n —C 3-10 carbocycle, and —(CR 6 R 6 ) n -4 to 10-membered heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, carbocycle, and heterocycle are substituted with 1-4 R 7 ;

alternatively, R 5 and R 5 are taken together with the nitrogen atom to which they are attached to form a 4- to 10-membered heterocycle substituted with 1-4 R 7 ;

R 7 , at each occurrence, is independently selected from H, ═O, NO 2 , halogen, C 1-4 alkyl, C 1-4 alkoxy, CN, OH, CF 3 , —(CH 2 ) n —CO 2 H, —(CH 2 ) n —CO 2 (C 1-4 alkyl), —(CH 2 ) n —NR 8 R 8 , —NHCO(C 1-4 alkyl), —NHCOCF 3 , —NHCO 2 (C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 3 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 OH, —NHCO 2 (CH 2 ) 2 NH 2 , —NHCO 2 (CH 2 ) 2 N(C 1-4 alkyl) 2 , —NHCO 2 CH 2 CO 2 H, —CH 2 NHCO 2 (C 1-4 alkyl), —NHC(O)NR 8 R 8 , —NHSO 2 (C 1-4 alkyl), —SO 2 NH 2 , —SO 2 NH(C 1-4 alkyl), —SO 2 N(C 1-4 alkyl) 2 , —SO 2 NH(CH 2 ) 20 H, —SO 2 NH(CH 2 ) 2 O(C 1-4 alkyl), —(CH 2 ) n —CONR 8 R 8 , —O(CH 2 ) n -carbocycle, —O(CH 2 ) n -heterocycle, —NHCO-carbocycle, —NHCO-heterocycle, —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, alkenyl, alkynyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

R 8 , at each occurrence, is independently selected from H, C 1-4 alkyl, C(O)C 1-4 alkyl, C(O)carbocycle, C(O)heterocycle, —(CH 2 ) n C(O)NR a R a , C(O)OC 1-4 alkyl, C(O)O-carbocycle, C(O)O-heterocycle, SO 2 alkyl, SO 2 carbocycle, SO 2 heterocycle, SO 2 NR a R a , —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle, wherein said alkyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

R 10 is selected from H and C 1-4 alkyl;

n, at each occurrence, is independently selected from 0, 1, 2, 3, and 4; and

p, at each occurrence, is independently selected from 0, 1, and 2.

8. The compound of claim 7 or a stereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:

M is N;

R 5 is selected from H, C 1-4 alkyl, —(CH 2 ) n —C 3-10 carbocycle, —(CH 2 ) n -aryl, —(CH 2 ) n -4- to 10-membered heterocycle selected from

wherein said alkyl, cycloalkyl, aryl are substituted with 1-4 R 7 ;

alternatively, R 5 and R 5 are taken together with the nitrogen atom to which they are attached to form a heterocycle selected from

R 9 , at each occurrence, is independently selected from halogen, OH, NO 2 , CHF 2 , CF 3 , C 1-4 alkyl, C 1-4 alkoxy, CH 2 OH, CO 2 H, CO 2 (C 1-4 alkyl), CONH 2 , —NH 2 , and a 4- to 10-membered heterocycle.

9. The compound of claim 1 having Formula (VIII):

or a stereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:

M is selected from N and CH;

R 1 is NR 5 R 5 ;

R 5 and R 5 are taken together with the nitrogen atom to which they are attached to form a heterocycle selected from

R 7 , at each occurrence, is independently selected from H, ═O, F, Cl, Br, C 1-4 alkyl, C 1-4 alkoxy, CN, OH, CF 3 , —(CH 2 ) n —NR 8 R 8 , —NHSO 2 (C 1-4 alkyl), —SO 2 NH 2 , —SO 2 NH(C 1-4 alkyl), —SO 2 N(C 1-4 alkyl) 2 , —(CH 2 ) n —CONR 8 R 8 , —(CH 2 ) n -phenyl, and —(CH 2 ) n -heterocycle selected from

R 8 , at each occurrence, is independently selected from H, CF 3 , CD 3 , CH 3 , C(CH 3 ) 3 ,

alternatively, R 8 and R 8 are taken together to form

and

R 9 , at each occurrence, is independently selected from F, Cl, OH, NO 2 , CHF 2 , (CH 2 ) 0-2 CF 3 , CD 3 , CH 3 , OC 1-4 alkyl, SO 2 NH 2 , and phenyl substituted with C 1-4 alkyl.

10. The compound of claim 3 , having Formula (IV):

or a stereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:

R 1 is selected from

R 7 , at each occurrence, is independently selected from H, ═O, NO 2 , halogen, C 1-4 alkyl, C 1-4 alkoxy, CN, OH, CF 3 , —(CH 2 ) n —CO 2 H, —(CH 2 ) n —CO 2 (C 1-4 alkyl), —(CH 2 ) n —NR 8 R 8 , —NHCO(C 1-4 alkyl), NHCOCF 3 , —NHCO 2 (C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 3 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 OH, —NHCO 2 (CH 2 ) 2 NH 2 , —NHCO 2 (CH 2 ) 2 N(C 1-4 alkyl) 2 , —NHCO 2 CH 2 CO 2 H, —CH 2 NHCO 2 (C 1-4 alkyl), —NHC(O)NR 8 R 8 , —NHSO 2 (C 1-4 alkyl), —SO 2 NH(C 1-4 alkyl), —SO 2 N(C 1-4 alkyl) 2 , —SO 2 NH(CH 2 ) 2 OH, —SO 2 NH(CH 2 ) 2 O(C 1-4 alkyl), —(CH 2 ) n —CONR 8 R 8 , —O(CH 2 ) n -carbocycle, —O(CH 2 ) n -heterocycle, —NHCO-carbocycle, —NHCO-heterocycle, —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, alkenyl, alkynyl, alkoxylm carbocycle, and heterocycle are substituted with 0-4 R 9 ;

R 8 , at each occurrence, is independently selected from H, C 1-4 alkyl, C(O)C 1-4 alkyl, C(O)carbocycle, C(O)heterocycle, —(CH 2 ) n -C(O)NR a R a , C(O)OC 1-4 alkyl, C(O)O-carbocycle, C(O)O-heterocycle, SO 2 alkyl, SO 2 carbocycle, SO 2 heterocycle, SO 2 NR a R a , —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle, wherein said alkyl, cabocycle, and heterocycle are substituted with 0-4 R 9 ;

alternatively, R 8 and R 8 are taken together with the nitrogen atom to which they are attached to form a 4- to 10-membered heterocycle substituted with 0-4 R 9 ;

R 9 , at each occurrence, is independently selected from halogen, OH, CN, NO 2 , CHF 2 , CF 3 , C 1-4 alkyl, C 1-4 alkoxy, CH 2 OH, CO 2 H, CO 2 (C 1-4 alkyl), CONH 2 , —(CH 2 ) n NR a R a , —(CH 2 ) n CONR a R a , —(CH 2 ) n NHCO(C 1-4 alkyl), —O(CH 2 ) n heterocycle, —O(CH 2 ) 2-4 NR a R a , and —(CR 10 R 10 ) n -4- to 10-membered heterocycle, wherein said alkyl, alkoxy, carbocycle, and heterocycle are substituted with 0-4 R b ;

R a , at each occurrence, is independently selected from H and C 1-4 alkyl; alternatively, R a and R a are taken together with the nitrogen atom to which they are attached to form a 4- to 10-membered heterocycle, wherein said alkyl, alkylene, and heterocycle are substituted with 0-4 R b ; and

R b , at each occurrence, is independently selected from ═O, halogen, C 1-4 alkyl, C 1-4 alkoxy, OCF 3 , NH 2 , NO 2 , N(C 1-4 alkyl) 2 , CO(C 1-4 alkyl), CO(C 1-4 haloalkyl), CO 2 (C 1-4 alkyl), CONH 2 , —CONH(C 1-4 alkyl), —CON(C 1-4 alkyl) 2 , —CONH—C 1-4 alkylene—O(C 1-4 alkyl), —CONH—C 1-4 alkylene—N(C 1-4 alkyl) 2 , and —NHCO 2 (C 1-4 alkyl).

11. The compound of claim 10 or stereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:

R 1 is selected from

R 7 , at each occurrence, is independently selected from H, halogen, C 1-4 alkyl, C 1-4 alkoxy, —NR 8 R 8 , C 3-6 ctcloaklkyl, phenyl, and —(CH 2 ) n -heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, alkenyl, alkynyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

R 8 , at each occurrence, is independently selected from H, C 1-4 alkyl, —(CH 2 ) n -C 3-6 cycloalkyl, —(CH 2 ) n -phenyl, and —(CH 2 ) n -heterocycle, wherein said alkyl, cycloalkyl, phenyl, and heterocycle are substituted with 0-4 R 9 ;

alternatively, R 8 and R 8 are taken together with the nitrogen atom to which they are attached to form a heterocycle selected from

R 9 , at each occurrence, is independently selected from F, Cl, OH, CN, C 1-4 alkyl, C 1-4 alkoxy, —(CH 2 ) n NR a R a , and a 4- to 10-membered heterocycle, wherein said alkyl, alkoxyl, and heterocycle are substituted with 0-4 R b ;

R a , at each occurrence, is independently selected from H, C 1-4 alkyl, —(CH 2 ) n OH, CO(C 1-4 alkyl), COCF 3 , CO2(C 1-4 alkyl), —CONH 2 , —CONH—C 1-4 alkylene—CO 2 (C 1-4 alkyl), and C 1-4 alkylene—CO 2 (C 1-4 alkyl); and

R b , at each occurrence, is independently selected from halogen, C 1-4 alkyl, C 1-4 alkoxy, OCF 3 , NH 2 , NO 2 , N(C 1-4 alkyl) 2 , CO(C 1-4 alkyl), CO(C 1-4 haloalkyl), CO 2 (C 1-4 alkyl), CONH 2 , —CONH(C 1-4 alkyl), —CON(C 1-4 alkyl) 2 , —CONH—C 1-4 alkylene—O(C 1-4 alkyl), —CONH—C 1-4 alkylene—N(C 1-4 alkyl) 2 , —C 1-4 alkylene—O—P(O)(OH) 2 , and NHCO 2 (C 1-4 alkyl).

12. The compound of claim 3 , having Formula (VIII):

or a stereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:

M is selected from N and CH;

R 1 is selected from

R 7 , at each occurrence, is independently selected from H, ═O, NO 2 , F, Cl, Br, C 1-6 alkyl, C 2-4 alkenyl, C 2-4 alkynyl, C 1-4 alkoxy, CN, OH, CF 3 , —(CH 2 ) n -CO 2 H, —(CH 2 ) n -CO 2 (C 1-4 alkyl), —(CH 2 ) n -NR 8 R 8 , —NHCOH, —NHCOH, —NHCO(C 1-4 alkyl), —NHCOCF 3 , —NHCO 2 (C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 3 O(C 1-4 alkyl), —NHCO 2 (CH 2 ) 2 OH, —NHCO 2 (CH 2 ) 2 NH 2 , —NHCO 2 (CH 2 ) 2 N(C 1-4 alkyl) 2 , —NHCO 2 CH 2 CO 2 H, —(CH 2 )1-2NHCO 2 (C 1-4 alkyl), —NHC(O)NR 8 R 8 , —NHSO 2 (C 1-4 alkyl), S(C 1-4 alkyl), —SO 2 NH 2 , —SO 2 NH(C 1-4 alkyl), —SO 2 N(C 1-4 alkyl) 2 , —SO 2 NH(CH 2 ) 2 OH, —SO 2 NH(CH 2 ) 2 O(C 1-4 alkyl), —(CH 2 ) n —CONR 8 R 8 , —O(CH 2 ) n -carbocycle, —O(CH 2 ) n -heterocycle, —NHCO-carbocycle, —NHCO-heterocycle, —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, alkenyl, alkynyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 R 9 and wherein said carbocycle is selected from

and wherein said heterocycle is selected from

R 8 , at each occurrence, is independently selected from H, C 1-4 alkyl, C(O)C 1-4 alkyl, C(O)carbocycle, C(O)heterocycle, —(CH 2 ) n —C(O)NR a R a , —(CH 2 ) n —NHC(O)C 1-4 alkyl, C(O)O—C 1-4 alkyl, C(O)O-carbocycle, C(O)O-heterocycle, SO 2 alkyl, SO 2 carbocycle, SO 2 heterocycle, SO 2 NR a R a , —(CH 2 ) n —C 3-6 cycloalkyl, —(CH 2 ) n -aryl, and —C(CH 2 ) n -heterocycle, wherein said alkyl, cycloalkyl, aryl, and heterocycle are substituted with 0-4 R 9 ;

alternatively, R 8 and R 8 are taken together with the nitrogen atom to which they are attached to form a heterocycle selected from

R 9 , at each occurrence, is independently selected from F, Cl, Br, I, OH, —O, CN, NO 2 , CHF 2 , CF 3 , C 1-4 alkyl, C 1-4 alkoxy, CH 2 OH, CO 2 H, CO 2 (C 1-4 alkyl), CONH 2 , —(CH 2 ) n NR a R a , —(CH 2 ) n CONR a R a , —(CH 2 ) n NHCO(C 1-4 alkyl), —O(CH 2 ) n heterocycle, —O(CH 2 ) 2-4 NR a R a , —(CH 2 ) n -carbocycle, and —(CH 2 ) n -4- to 10-membered heterocycle, wherein said alkyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 R b ;

R a , at each occurrence, is independently selected from H and C 1-4 alkyl; alternatively, R a abd R a are taken together with the nitrogen atom to which theu are attached to form a 4- to 10-membered heterocycle, wherein said alkyl, alkylene, and heterocycle are substituted with 0-4 R b ;

R b , at each occurrence, is independently selected from ═O, halogen, C 1-4 alkyl, C 1-4 alkoxy, OCF 3 , OC(O)C 1-4 alkyl, NH 2 , NO 2 , N(C 1-4 alkyl) 2 , CO(C 1-4 alkyl), CO(C 1-4 haloalkyl), CO 2 (C 1-4 alkyl), CONH 2 , —CONH(C 1-4 alkyl), —CON(C 1-4 alkyl) 2 , —CONH—C 1-4 alkylene—O(C 1-4 alkyl), —CONH—C 1-4 alkylene—N(C 1-4 alkyl) 2 , and —NHCO 2 (C 1-4 alkyl), wherein said alkyl and alkoxy are substituted with R d ;

R d , at each occurrence, is independently selected from ═O, halogen, —OH, C 1-4 alkyl, NH 2 , NH(C 1-4 alkyl), N(C 1-4 alkyl) 2 , C 1-4 alkoxy, and —NHCO(C 1-4 alkyl), and a heterocycle containing carbon atoms and 1-4 heteroatoms selected deom the group cobsisting of: N, NH, N(C 1-4 alkyl), O, and S(O) p ;

n, at each occurrence, is independently selected from 0, 1, 2, 3, and 4; and

p, at each occurrence, is independently selected from 0, 1, and 2.

13. The compound of claim 7 or a stereoisomer, a tautomer, a pharmaceutically-acceptable salt thereof, wherein:

M is N;

R 1 and R 6 are taken together with the nitrogen atom to which they are attached to form a heterocycle selected from

R 7 , at each occurrence, is independently selected from H, halogen, C 1-4 alkyl, C 1-4 alkoxy, CN, OH, CF 3 , —(CH 2 ) n -—CO 2 H, —(CH 2 ) n —CO 2 (C 1-4 alkyl), —(CH 2 ) n —NR 8 R 8 , —NHCO(C 1-4 alkyl), —NHC(O)NR 8 R 8 , —NHSO 2 (C 1-4 alkyl), —SO 2 NH 2 , —SO 2 NH(C 1-4 alkyl), —SO 2 N(C 1-4 alkyl) 2 , —SO 2 NH(CH 2 ) 2 OH, —SO 2 NH(CH 2 ) 2 O(C 1-4 alkyl), —(CH 2 ) n —CONR 8 R 8 , —(CH 2 ) n -carbocycle, and —(CH 2 ) n -heterocycle comprising carbon atoms and 1-4 heteroatoms selected from N, NR 8 , O, and S(O) p , wherein said alkyl, alkenyl, alkynyl, alkoxyl, carbocycle, and heterocycle are substituted with 0-4 R 9 ;

R 8 , at each occurrence, is independently selected from H and C 1-4 alkyl:

R 9 , at each occurrence, is independently selected from halogen, OH, CN, NO 2 , CHF 2 , CF 3 , C 1-4 alkyl, C 1-4 alkoxy, CH 2 OH, CO(C 1-4 alkyl), CO 2 H, and CO 2 (C 1-4 alkyl);

n, at each occurrence, is independently selected from 0, 1, 2, 3, and 4; and

p, at each occurence, is independently selected from 0, 1, and 2.

14. A compound of claim 1 selected from the group consisting of

N-[6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indene-2-carboxamide,

4-(dimethylamino)-N-[6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

2-(naphthalen-1-yl)-N-[6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]acetamide,

2-(naphthalen-2-yl)-N-[6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]acetamide,

1-methyl-N-[6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

N-[6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-3-phenylpropanamide,

N-[6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-(2,2,2-trifluoroethyl)-1H-pyrazole-3-carboxamide,

3-methyl-N-[6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-phenyl-1H-pyrazole-4-carboxamide,

1-tert-butyl-N-[6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-4-carboxamide,

N-[6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-phenyl-1H-pyrazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-N-[6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

N-[6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-phenyl-1H-pyrazole-4-carboxamide,

5-methyl-N-[6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-phenyl-1H-pyrazole-4-carboxamide,

1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-(2,2,2-trifluoroethyl)-1H-pyrazole-3-carboxamide,

1-(2,2-difluoroethyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-3-carboxamide,

1-methyl-N-[(aS)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

N-[(aS)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-(2,2,2-trifluoroethyl)-1H-pyrazole-3-carboxamide,

1-(2,2-difluoroethyl)-N-[(aS)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-3-carboxamide,

5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-phenyl-1H-pyrazole-4-carboxamide,

1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-(3,3,3-trifluoropropyl)-1H-pyrazole-3-carboxamide,

1-(cyclopropylmethyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-3-carboxamide,

3-cyclopropyl-1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-5-carboxamide,

1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide,

5-cyclopropyl-1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-3-carboxamide,

1-cyclopropyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-4-carboxamide,

5-(difluoromethoxy)-1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-3-carboxamide,

1-cyclopropyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-3-carboxamide,

6-fluoro-1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2,2-difluoroethyl)-3-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-4-carb oxamide,

4-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2-(piperidin-1-yl)-1,3-thiazole-5-carboxamide,

4-methyl-2-(morpholin-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-5-carboxamide,

4-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2-(pyrrolidin-1-yl)-1,3-thiazole-5-carboxamide,

2-[(3 S)-3-fluoropyrrolidin-1-yl]-4-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-5-carboxamide,

2-[(3R)-3-fluoropyrrolidin-1-yl]-4-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-5-carboxamide,

2-[(3 S)-3-cyanopyrrolidin-1-yl]-4-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-5-carboxamide,

2-[(3R)-3-cyanopyrrolidin-1-yl]-4-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-5-carboxamide,

rel-2-[(1 S,5R)-2-azabicyclo[3.1]hexan-2-yl]-4-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-5-carboxamide,

2-(3,3-difluoropyrrolidin-1-yl)-4-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-5-carboxamide,

2-(cyclopropylamino)-4-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-5-carboxamide,

4-(aR)-{6-[(5-phenyl-1,3,4-thiadiazol-2-yl)amino]spiro[3.3]heptan-2-yl}-1,2-dihydrophthalazin-1-one,

4-(aR)-{6-[(5-phenyl-1,3-oxazol-2-yl)amino]spiro[3.3]heptan-2-yl}-1,2-dihydrophthalazin-1-one,

4-(aR)-{6-[(phthalazin-1-yl)amino]spiro[3.3]heptan-2-yl}-1,2-dihydrophthalazin-1-one,

4-[6-(2,3-dihydro-1H-indole-1-carbonyl)spiro[3.3]heptan-2-yl]-1,2-dihydrophthalazin-1-one,

4-[6-(2,3-dihydro-1H-isoindole-2-carbonyl)spiro[3.3]heptan-2-yl]-1,2-dihydrophthalazin-1-one,

N-(5-methyl-1,3,4-thiadiazol-2-yl)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptane-2-carboxamide,

N-(5-methyl-1,2-oxazol-3-yl)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptane-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-isoindole-2-carboxamide,

4-{6-[2-(2,3-dihydro-1H-indol-1-yl)-2-oxoethyl]spiro[3.3]heptan-2-yl}-1,2-dihydrophthalazin-1-one,

2-[(3R)-3-fluoropyrrolidin-1-yl]-5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-4-carboxamide,

2-(3,3-difluoropyrrolidin-1-yl)-5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-4-carboxamide,

2-[(3 S)-3-cyanopyrrolidin-1-yl]-5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-4-carboxamide,

2-[(3R)-3-cyanopyrrolidin-1-yl]-5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-4-carboxamide,

2-[(3,3-difluorocyclobutyl)amino]-5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-4-carboxamide,

2-[(3 S)-3-fluoropyrrolidin-1-yl]-5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-4-carboxamide,

5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2-[(2 S)-2-(trifluoromethyl)pyrrolidin-1-yl]-1,3-thiazole-4-carboxamide,

5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2-[(2R)-2-(trifluoromethyl)pyrrolidin-1-yl]-1,3-thiazole-4-carboxamide,

1-(2-hydroxy-2-methylpropyl)-5-methoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-6-methoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

6-methoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

5-methoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

5-fluoro-1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrrolo[2,3-b]pyridine-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[2-(morpholin-4-yl)ethoxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

2-(morpholin-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-thiazole-5-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2-(pyrrolidin-1-yl)-1,3-thiazole-5-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,2-benzoxazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-3-carboxamide,

5-[2-(morpholin-4-yl)ethoxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

5-(2-hydroxy-3-methoxypropoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(morpholin-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

5-(2-hydroxyethoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,1-benzoxazole-3-carboxamide,

6-(difluoromethoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2,2-difluoroethoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-[2-(1H-pyrazol-1-yl)ethoxy]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(4,4-difluoropiperidin-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-[2-(pyrrolidin-1-yl)ethoxy]pyrazolo[1,5-a]pyridine-3-carboxamide,

5-(morpholin-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

5-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(4-methylpiperazin-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[(3R)-3-fluoropyrrolidin-1-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[(3 S)-3-fluoropyrrolidin-1-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(3,3-difluoropyrrolidin-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(3-fluoroazetidin-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(3,3-difluoroazetidin-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzo[d]imidazo[2,1-b]thiazole-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[2,1-b][1,3]thiazole-6-carboxamide,

2-ethyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[2,1-b][1,3,4]thiadiazole-6-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-b]pyridazine-3-carboxamide,

7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-[3,3,3-trifluoro-2-hydroxy-2-(trifluoromethyl)propoxy]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(benzyloxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

1-(2,2-difluoroethyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-5-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-(3,3,3-trifluoropropyl)-1H-pyrazole-5-carboxamide,

1-[(4-methoxyphenyl)methyl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-4-carb oxamide,

1-(cyclopropylmethyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-5-carboxamide,

1-(oxan-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-5-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(oxolan-3-yloxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

tert-butyl N-[2-(4-{[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]carbamoyl}-1H-pyrazol-1-yl)ethyl]carbamate,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(3,3,3-trifluoro-2-hydroxypropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

1-(3-methoxyphenyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-4-carboxamide,

1-benzyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-4-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-3-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3,7-dicarboxamide,

7-cyano-6-hydroxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-7-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-7-(methoxymethyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-phenyl-1H-1,2,3-triazole-4-carboxamide,

1-(4-methoxyphenyl)-5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-1,2,3-triazole-4-carboxamide,

1-(3-methoxyphenyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-1,2,3-triazole-4-carboxamide,

1-(2-methoxyphenyl)-5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-1,2,3-triazole-4-carboxamide,

5-(4-fluorophenyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,2,4-oxadiazole-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(3,3,3-trifluoro-2-hydroxypropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(oxolan-3-yloxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

7-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

3-methoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-2-carboxamide,

6-(benzyloxy)-7-cyclopropyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(benzyloxy)-7-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(benzyloxy)-7-cyano-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

7-cyclopropyl-6-hydroxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

1-(2-methoxyphenyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-1,2,3-triazole-4-carboxamide,

6-(benzyloxy)-7-[(dimethylamino)methyl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[(1,3-difluoropropan-2-yl)oxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[(1,1-dioxo-1λ 6 -thian-4-yl)oxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(3,3,3-trifluoropropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[(4,4-difluorocyclohexyl)oxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(oxan-4-yloxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

methyl 3-[(3-{[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]carbamoyl}pyrazolo[1,5-a]pyridin-6-yl)oxy]azetidine-1-carboxylate,

6-hydroxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(3,3-difluorocyclobutoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-[2-(2,2,2-trifluoroethoxy)ethoxy]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[(5-cyclopropyl-1,3,4-thiadiazol-2-yl)methoxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(benzyloxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-7-(trifluoromethyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-cyclopropyl-1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-phenyl-1H-indazole-3-carboxamide,

6-(4-chlorophenyl)-1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-6-(1-methyl-1H-pyrazol-3-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-6-(1-methyl-1H-pyrazol-5-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-6-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-[(E)-2-phenylethenyl]-1H-indazole-3-carboxamide,

6-[(E)-2-cyclopropylethenyl]-1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-6-(6-methoxypyridin-2-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

6-[(Z)-2-cyclopropylethenyl]-1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

6-bromo-1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-6-(4-methoxyphenyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-6-(1-methyl-1H-1,2,3-triazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

6-(dimethyl-1,2-oxazol-4-yl)-1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

6-(3-chlorophenyl)-1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-6-(2-methoxyphenyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-6-(3-methoxyphenyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

6-(2, 6-difluorophenyl)-1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

6-(2-cyanophenyl)-1-(2-hydroxy-2-methylpropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-6-(1,2-oxazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

N-[6-fluoro-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-(2-hydroxy-2-methylpropyl)-1H-indazole-3-carboxamide,

6-fluoro-N-[6-fluoro-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-(2-hydroxy-2-methylpropyl)-1H-indazole-3-carboxamide,

N-[6-fluoro-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(2-oxopyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-cyclopropyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[1-(difluoromethyl)-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-cyano-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1, 5-a]pyridine-3-carboxamide,

6-(2-oxo-1,2-dihydropyridin-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-{1-[(2S)-3,3,3-trifluoro-2-hydroxypropyl]-1H-pyrazol-4-yl}pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-[3-(trifluoromethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(1,3-thiazol-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(dimethyl-1H-1,2,3-triazol-5-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1H-imidazol-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(1H-pyrazol-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(1H-1,2,4-triazol-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-methoxyethoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(4-oxo-1,4-dihydropyridin-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-hydroxyethoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[2-(3-fluoroazetidin-1-yl)ethoxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[2-(dimethylamino)ethoxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[2-(4-hydroxy-3,3-dimethylpiperidin-1-yl)ethoxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[2-(3,3-difluoropyrrolidin-1-yl)ethoxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[2-(azetidin-1-yl)ethoxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[2-(2,2-dimethylmorpholin-4-yl)ethoxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[2-(4-methylpiperazin-1-yl)ethoxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-{2-[(3R)-3-fluoropyrrolidin-1-yl]ethoxy}-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-{2-[(3 S)-3-fluoropyrrolidin-1-yl]ethoxy}-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[3-(morpholin-4-yl)propyl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-[3-(pyrrolidin-1-yl)propyl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[3-(dimethylamino)propyl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[3-(cyclopropylamino)propyl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(3-hydroxypropyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[3-(4,4-difluoropiperidin-1-yl)propyl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[3-(3,3-difluoropyrrolidin-1-yl)propyl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(3-hydroxy-3-methylbutyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-[4,4,4-trifluoro-3-hydroxy-3-(trifluoromethyl)butyl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(morpholin-4-ylmethyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[(4-methylpiperazin-1-yl)methyl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(piperidin-1-ylmethyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[(dimethylamino)methyl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-benzyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1, 5-a]pyridine-3-carboxamide,

6-[3-(morpholin-4-yl)-3-oxopropyl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(3,3,3-trifluoropropyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-cyanoethyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-{[2-(morpholin-4-yl)ethoxy]methyl}-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(methoxymethyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-methoxypyrimidin-5-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[(oxan-4-ylmethoxy)methyl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-[(prop-2-en-1-yloxy)methyl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(hydroxymethyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-acetyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1, 5-a]pyridine-3-carboxamide,

6-(2-hydroxypropan-2-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1,5-dimethyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1-cyclopropyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[1-( 2 H3)methyl-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-[1-(propan-2-yl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(trimethyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-[l 1-(propan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1-tert-butyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-[1-(oxolan-3-yl)-1H-pyrazol-4-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

1-(4-bromophenyl)-3-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]urea,

1-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-3-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]urea,

1-{4-[1-( 2 H3)methyl-1H-pyrazol-4-yl]phenyl}-3-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]urea,

1-[4-(1-cyclopropyl-1H-pyrazol-4-yl)phenyl]-3-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]urea,

1-{4-[1-(oxan-4-yl)-1H-pyrazol-4-yl]phenyl}-3-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]urea,

1-{4-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]phenyl}-3-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]urea,

3-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-[4-(trimethyl-1H-pyrazol-4-yl)phenyl]urea,

5-bromo-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

5-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

5-(1-cyclopropyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-5-(trimethyl-1H-pyrazol-4-yl)-2,3-dihydro-1H-indole-1-carboxamide,

5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

5-[1-( 2 H3)methyl-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

5-[l 1-(oxan-4-yl)-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

5-[1-(cyclopropylmethyl)-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

5-(1-tert-butyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-5-[1-(oxolan-3-yl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indole-1-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-5-[-(propan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-indole-1-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-5-(3,3,3-trifluoropropyl)-2,3-dihydro-1H-indole-1-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-5-(trimethyl-1H-pyrazol-4-yl)-2,3-dihydro-1H-isoindole-2-carboxamide,

5-(1-cyclopropyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-isoindole-2-carboxamide,

5-[1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-isoindole-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-5-[-(propan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]-2,3-dihydro-1H-isoindole-2-carboxamide,

5-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-isoindole-2-carboxamide,

5-[l 1-(oxan-4-yl)-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-isoindole-2-carboxamide,

5-(1-tert-butyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-isoindole-2-carboxamide,

5-[1-( 2 H3)methyl-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-isoindole-2-carboxamide,

3,3-dimethyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H,2H,3H-pyrrolo[2,3-b]pyridine-1-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-5H,6H,7H-pyrrolo[3,4-b]pyridine-6-carboxamide,

5-methoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(trifluoromethyl)-2,3-dihydro-1H-indole-1-carboxamide,

5-(dimethylsulfamoyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

3-(morpholin-4-ylmethyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-1-carboxamide,

2-(4-methylphenyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-5H, 6H,7H-pyrrolo[3,4-d]pyrimidine-6-carboxamide,

5-methoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-isoindole-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H,2H,3H-pyrrolo[3,4-c]pyridine-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,2-dihydrospiro[indole-3,4′-piperidine]-1-carboxamide,

N, 1-dimethyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

N-ethyl-1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-3-carboxamide,

2-methyl-1-[(3-{[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]carbamoyl}pyrazolo[1,5-a]pyridin-6-yl)oxy]propan-2-yl2-aminoacetate,

2-methyl-1-[(3-{[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]carbamoyl}pyrazolo[1,5-a]pyridin-6-yl)oxy]propan-2-yl (2S)-2-amino-3-methylbutanoate,

2-methyl-1-[(3-{[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]carbamoyl}pyrazolo[1,5-a]pyridin-6-yl)oxy]propan-2-yl (2S)-2-aminopropanoate,

6-(2-hydroxy-2-methylpropoxy)-N-[6-(1-oxo-1,2-dihydroisoquinolin-4-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

tert-butyl 3-{[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]carbamoyl})-4H, 5H,6H,7H-thieno[2,3-c]pyridine-6-carboxylate,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4H, 5H, 6H,7H-thieno[2,3-c]pyridine-3-carboxamide,

6-acetyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4H, 5H, 6H,7H-thieno[2,3-c]pyridine-3-carboxamide,

methyl 3-{[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]carbamoyl})-4H, 5H,6H,7H-thieno[2,3-c]pyridine-6-carboxylate,

6-methanesulfonyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4H, 5H,6H,7H-thieno[2,3-c]pyridine-3-carboxamide,

6-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,1-benzoxazole-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-N-(6-{4-oxo-3H,4H-pyrrolo[1,2-d][1,2,4]triazin-1-yl})spiro[3.3]heptan-2-yl)-1H-indazole-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-(6-{4-oxo-3H,4H-pyrrolo[1,2-d][1,2,4]triazin-1-yl}spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

1-methyl-N-(6-{4-oxo-3H,4H-pyrrolo[1,2-d][1,2,4]triazin-1-yl)}spiro[3.3]heptan-2-yl)-1H-indazole-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-(6-{8-methyl-4-oxo-3H,4H-pyrrolo[1,2-d][1,2,4]triazin-1-yl}spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide,

6-[(3,5-dimethylphenyl)amino]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-b]pyridazine-3-carboxamide,

6-bromo-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,1-benzoxazole-3-carboxamide,

1-ethyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-5-carboxamide,

1-(difluoromethyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrazole-5-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,1-benzoxazole-3-carboxamide,

1-(3-chlorophenyl)-7-oxo-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide,

1-(4-methoxyphenyl)-7-oxo-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H,4H,5H,6H,7H-pyrazolo[3,4-c]pyridine-3-carboxamide,

5-chloro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,2-benzoxazole-3-carboxamide,

6-acetamido-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,2-benzoxazole-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,5-a]pyridine-1-carboxamide,

5-methoxy-1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

7-methoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4H,5H,6H,7H-[1,3]thiazolo[5,4-c]pyridine-2-carboxamide,

4-chloro-1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

2-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-3-carboxamide,

7-chloro-1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

4-chloro-7-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]thieno[2,3-b]pyrazine-6-carboxamide,

4-bromo-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1, 5-a]pyridine-3-carboxamide,

6-chloro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-1,3-benzodiazole-2-carboxamide,

5-chloro-1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-(propan-2-yl)-1H-1,3-benzodiazole-5-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-1,3-benzodiazole-5-carboxamide,

2-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-1,3-benzodiazole-5-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-3H-imidazo[4,5-b]pyridine-6-carboxamide,

4-formamido-3-hydroxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-pyrrolo[2,3-b]pyridine-2-carboxamide,

6-chloro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-benzothiophene-2-carboxamide,

6-methoxy-1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

2-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1,3-benzoxazole-6-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-6-carboxamide,

1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-1,3-benzodiazole-5-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

5-(benzyloxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

6-fluoro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indene-1-carboxamide,

7-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-isoindole-1-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]isoquinoline-3-carboxamide,

7-hydroxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

7-chloro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

6-fluoro-7-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]quinoline-2-carboxamide,

4-bromo-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-7-(trifluoromethyl)-1H-indole-2-carboxamide,

7-fluoro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

4,7-dimethoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

5-fluoro-7-methanesulfonyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-3-(1H-pyrazol-1-yl)benzamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4-(1H-pyrazol-4-yl)benzamide,

3-[2-(morpholin-4-yl)ethoxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-3-(1H-pyrazol-4-yl)benzamide,

3-(4-methyl-1,3-thiazol-2-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

6-methoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(trifluoromethyl)pyridine-3-carboxamide,

2-hydroxy-6-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-[2-(pyrrolidin-1-yl)ethyl]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4-(2H-1,2,3,4-tetrazol-5-yl)benzamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(1H-pyrazol-1-yl)pyridine-3-carboxamide,

5-chloro-6-hydroxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4-(1H-1,2,4-triazol-1-yl)benzamide,

3-methoxy-4-(4-methyl-1H-imidazol-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

3-methoxy-4-(2-methyl-1,3-thiazol-5-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

5-methoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyridine-2-carboxamide,

3-(1H-imidazol-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

3-cyano-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4-(propan-2-yloxy)benzamide,

3-(difluoromethoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

4-ethoxy-5-oxo-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1-(2,2,2-trifluoroethyl)-2, 5-dihydro-1H-pyrrole-3-carboxamide,

6-(dimethylamino)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4-(1H-pyrazol-3-yl)benzamide,

4-(1,3-oxazol-5-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

4-(1H-imidazol-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

4-(5-methyl-1,2,4-oxadiazol-3-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-3-(1H-pyrazol-3-yl)benzamide,

8-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-2-carboxamide,

6-bromo-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-2-carboxamide,

1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-3-carboxamide,

5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2-(pyridin-4-yl)-1,3-thiazole-4-carboxamide,

1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-6-carboxamide,

1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-6-carboxamide,

1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-5-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-5-(pyrrolidin-1-yl)pyridine-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-5-(trifluoromethyl)pyridine-2-carboxamide,

5-cyano-6-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyridine-2-carboxamide,

7-methoxy-3-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

1-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indazole-5-carboxamide,

7-bromo-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-2-carboxamide,

5-bromo-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyridine-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-2-carboxamide,

7-(4-methylpiperazin-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-cyano-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

8-cyano-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-8-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxamide,

8-chloro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-7-phenylimidazo[1,2-a]pyridine-3-carboxamide,

7-(benzyloxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-methoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

8-chloro-7-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-fluoro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-3-(propan-2-yl)-5H,6H,7H,8H-imidazo[1,5-a]pyridine-1-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-[1,2,4]triazolo[4,3-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxamide,

7-(4,4-difluoropiperidin-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-(3,3-difluoropyrrolidin-1-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-[(3R)-3-fluoropyrrolidin-1-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-[(3 S)-3-fluoropyrrolidin-1-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-[(3R)-3-hydroxypyrrolidin-1-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-[(2-hydroxyethyl)(methyl)amino]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-[(2-methoxyethyl)(methyl)amino]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-[2-(morpholin-4-yl)ethoxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-[(2-hydroxy-2-methylpropyl)(methyl)amino]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-(2-hydroxy-2-methylpropoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-7-[2-(pyrrolidin-1-yl)ethoxy]imidazo[1,2-a]pyridine-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-7-oxo-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H,7H-imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-7-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxamide,

8-fluoro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6-(trifluoromethyl)imidazo[1,2-a]pyridine-3-carboxamide,

6-fluoro-8-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-(difluoromethoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

6-fluoro-5-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

6-fluoro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-[(2-hydroxy-2-methylpropyl)amino]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

6-fluoro-7-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

6, 8-difluoro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

8-(benzyloxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-(methyl sulfanyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

4-oxo-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4H, 5H, 6H,7H-pyrazolo[1,5-a]pyrazine-2-carboxamide,

3-methoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4-(1H-pyrazol-4-yl)benzamide,

3-cyano-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4-(1H-pyrazol-4-yl)benzamide,

3-methyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4-(1H-pyrazol-4-yl)benzamide,

2-methoxy-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4-(1H-pyrazol-4-yl)benzamide,

7-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-1H-indole-2-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-6H-isochromeno[4,3-d]pyrimidine-8-carboxamide,

3-methoxy-4-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

3-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

6-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyridine-3-carboxamide,

7-acetyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

3-fluoro-4-[1-( 2 H3)methyl-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

4-[1-(difluoromethyl)-1H-pyrazol-4-yl]-3-fluoro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

7-(2-hydroxypropan-2-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-(1-hydroxyethyl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-[(1,1-dioxo-1λ 6 -thian-4-yl)oxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-7-(3,3,3-trifluoropropoxy)imidazo[1,2-a]pyridine-3-carboxamide,

7-[(1,3-difluoropropan-2-yl)oxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-7-(pyridin-2-yloxy)imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-3-(propan-2-yl)imidazo[1,5-a]pyridine-1-carboxamide,

7-(2,2-difluoroethoxy)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-7-(propan-2-yloxy)imidazo[1,2-a]pyridine-3-carboxamide,

4-(morpholin-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

7-(1-ethyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-7-[1-(propan-2-yl)-1H-pyrazol-4-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-[1-( 2 H 3 )methyl-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-7-[1-(propan-2-yl)-3-(trifluoromethyl)-1H-pyrazol-4-yl]imidazo[1,2-a]pyridine-3-carboxamide,

4-(1-ethyl-1H-pyrazol-4-yl)-3-fluoro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

3-fluoro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-4-[1-(propan-2-yl)-1H-pyrazol-4-yl]benzamide,

3-fluoro-4-[1-methyl-5-(trifluoromethyl)-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

4-(1-cyclopropyl-1H-pyrazol-4-yl)-3-fluoro-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

3-fluoro-4-[1-(oxan-4-yl)-1H-pyrazol-4-yl]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

5-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyridine-2-carboxamide,

4-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]benzamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-2-carboxamide,

7-(2-methyl-1,3-thiazol-5-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-2-carboxamide,

7-(2-methyl-1,3-thiazol-5-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

4-[6-(1-oxo-2,3-dihydro-1H-isoindol-2-yl)spiro[3.3]heptan-2-yl]-1,2-dihydrophthalazin-1-one,

4-{6-[(4S)-4-benzyl-2-oxoimidazolidin-1-yl]spiro[3.3]heptan-2-yl}-1,2-dihydrophthalazin-1-one,

4-{6-[(4R)-4-benzyl-2-oxoimidazolidin-1-yl]spiro[3.3]heptan-2-yl}-1,2-dihydrophthalazin-1-one,

4-{6-[(2-nitrophenyl)amino]spiro[3.3]heptan-2-yl}-1,2-dihydrophthalazin-1-one,

4-[6-(2-oxo-2,3-dihydro-1H-1,3-benzodiazol-1-yl)spiro[3.3]heptan-2-yl]-1,2-dihydrophthalazin-1-one,

4-cyclopropyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyridine-3-carboxamide,

3-fluoro-5-(1-methyl-1H-pyrazol-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyridine-2-carboxamide,

6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl-2,3-dihydro-1H-isoindole-2-carboxylate,

7-methanesulfonyl-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]pyrazolo[1,5-a]pyrazine-3-carboxamide,

5-bromo-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]-2,3-dihydro-1H-indole-2-carboxamide,

2-methyl-2-[(3-{[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]carbamoyl}pyrazolo[1,5-a]pyridin-6-yl)oxy]propanoic acid,

7-(morpholin-4-yl)-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

7-[(4,4-difluorocyclohexyl)oxy]-N-[(aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl]imidazo[1,2-a]pyridine-3-carboxamide,

4-Methyl-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-2-(piperidin-1-yl)thiazole-5-carboxamide,

2-(3,3-difluoropyrrolidin-1-yl)-5-methyl-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)thiazole-4-carboxamide,

1-(2-hydroxy-2-methylpropyl)-6-methoxy-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-1H-indazole-3-carboxamide,

6-methoxy-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-1H-indole-3-carboxamide,

6-(2,2-difluoroethoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-(1H-pyrazol-1-yl)ethoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(4-methylpiperazin-1-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-6-(pyrrolidin-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-((R)-3-fluoropyrrolidin-1-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-((S)-3-fluoropyrrolidin-1-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(3,3-difluoropyrrolidin-1-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(3-fluoroazetidin-1-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(3,3-difluoroazetidin-1-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

7-cyclopropyl-6-(2-hydroxy-2-methylpropoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(benzyloxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-6-((tetrahydrofuran-3-yl)oxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-6-(3,3,3-trifluoro-2-hydroxypropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(benzyloxy)-7-methyl-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(benzyloxy)-7-cyano-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-((1,3-difluoropropan-2-yl)oxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-6-(3,3,3-trifluoropropoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-((4,4-difluorocyclohexyl)oxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-6-((tetrahydro-2H-pyran-4-yl)oxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(3,3-difluorocyclobutoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-6-(2-(2,2,2-trifluoroethoxy)ethoxy)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-((5-cyclopropyl-1,3,4-thiadiazol-2-yl)methoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

1-(2-hydroxy-2-methylpropyl)-6-(2-methoxyphenyl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-1H-indazole-3-carboxamide,

6-(2-cyanophenyl)-1-(2-hydroxy-2-methylpropyl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-1H-indazole-3-carboxamide,

6-cyclopropyl-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1-(difluoromethyl)-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1-methyl-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-6-(thiazol-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-6-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-6-(1H-pyrazol-1-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-methoxyethoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-(4-hydroxy-3,3-dimethylpiperidin-1-yl)ethoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-(3,3-difluoropyrrolidin-1-yl)ethoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-(2,2-dimethylmorpholino)ethoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-(4-methylpiperazin-1-yl)ethoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-((R)-3-fluoropyrrolidin-1-yl)ethoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(2-((S)-3-fluoropyrrolidin-1-yl)ethoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(3-(3,3-difluoropyrrolidin-1-yl)propyl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(3-hydroxy-3-methylbutyl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-benzyl-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1, 5-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-6-(3,3,3-trifluoropropyl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-((allyloxy)methyl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1,5-dimethyl-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1-cyclopropyl-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1-(cyclopropylmethyl)-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1-(( 2 H3)methyl-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1-isopropyl-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-6-(1,3,5-trimethyl-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-6-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1-isopropyl-3-(trifluoromethyl)-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

6-(1-(tert-butyl)-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-6-(1-(tetrahydrofuran-3-yl)-1H-pyrazol-4-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

5-(1-methyl-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)indoline-1-carboxamide,

5-(1-cyclopropyl-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)indoline-1-carboxamide,

5-(1-( 2 H3)methyl-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)indoline-1-carboxamide,

2-methyl-1-((3-(((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)carbamoyl)pyrazolo[1,5-a]pyridin-6-yl)oxy)propan-2-yl-2-aminoacetate,

(S)-2-methyl-1-((3-(((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)carbamoyl)pyrazolo[1,5-a]pyridin-6-yl)oxy)propan-2-yl-2-amino-3-methylbutanoate,

(S)-2-methyl-1-((3-(((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)carbamoyl)pyrazolo[1,5-a]pyridin-6-yl)oxy)propan-2-yl-2-aminopropanoate,

6-(1-methyl-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)benzo[c]isoxazole-3-carboxamide,

6-(2-hydroxy-2-methylpropoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)benzo[c]isoxazole-3-carboxamide,

6-fluoro-7-methyl-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-1H-indole-2-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-7-(trifluoromethyl)-1H-indole-2-carboxamide,

7-(4-methylpiperazin-1-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide),

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-7-phenylimidazo[1,2-a]pyridine-3-carboxamide,

7-(benzyloxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-methoxy-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-(4,4-difluoropiperidin-1-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-(3,3-difluoropyrrolidin-1-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-((R)-3-fluoropyrrolidin-1-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-((S)-3-fluoropyrrolidin-1-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-((2-methoxyethyl)(methyl)amino)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-(2-morpholinoethoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-(2-hydroxy-2-methylpropoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

6-fluoro-8-methyl-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-(difluoromethoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

8-(benzyloxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-(methylthio)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

3-methoxy-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-4-(1H-pyrazol-4-yl)benzamide,

3-cyano-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-4-(1H-pyrazol-4-yl)benzamide,

3-methyl-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-4-(1H-pyrazol-4-yl)benzamide,

7-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)oxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-7-(pyridin-2-yloxy)imidazo[1,2-a]pyridine-3-carboxamide,

7-(2,2-difluoroethoxy)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-(1-ethyl-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-(1-methyl-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-(1-isopropyl-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

7-(1-(methyl-d3)-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-7-(1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazol-4-yl)imidazo[1,2-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-3-carboxamide,

N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)-7-(pyridin-3-yl)imidazo[1,2-a]pyridine-2-carboxamide,

7-(2-methylthiazol-5-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-2-carboxamide,

7-(2-methylthiazol-5-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide,

4-((aR)-6-(1-oxoisoindolin-2-yl)spiro[3.3]heptan-2-yl)phthalazin-1(2H)-one,

4-((aR)-6-((S)-4-benzyl-2-oxoimidazolidin-1-yl)spiro[3.3]heptan-2-yl)phthalazin-1 (2H)-one

4-((aR)-6-((R)-4-benzyl-2-oxoimidazolidin-1-yl)spiro[3.3]heptan-2-yl)phthalazin-1 (2H)-one,

4-((aR)-6-((2-nitrophenyl)amino)spiro[3.3]heptan-2-yl)phthalazin-1 (2H)-one,

4-((aR)-6-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)spiro[3.3]heptan-2-yl)phthalazin-1(2H)-one,

4-cyclopropyl-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)pyrazolo[1,5-a]pyridine-3-carboxamide,

3-fluoro-5-(1-methyl-1H-pyrazol-4-yl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)picolinamide,

6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl isoindoline-2-carboxylate,

7-(methylsulfonyl)-N-((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)imidazo[1,2-a]pyridine-3-carboxamide, and

2-methyl-2-((3-(((aR)-6-(4-oxo-3,4-dihydrophthalazin-1-yl)spiro[3.3]heptan-2-yl)carbamoyl)pyrazolo[1,5-a]pyridin-6-yl)oxy)propanoic acid.

15. A pharmaceutical composition comprising one or more compounds according to claim 1 and a pharmaceutically acceptable carrier or diluent.

Assignments (1)

ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 4, 2015

From: LADZIATA, VLADIMIR; GLUNZ, PETER W.; HU, ZILUN; WANG, YUFENG

To: BRISTOL-MYERS SQUIBB COMPANY

Reel/Frame 036243/0764 →

Continuity (2)

Provisional Application 62024555 · Jul 15, 2014

Related Publication 20160016914A1 · Jan 21, 2016