IP Library › Granted Patent US 9,902,740
Granted Patent B2
US 9,902,740 · App. 15/606,512 · Granted Feb 27, 2018

Macrocyclic benzodiazepine dimers, conjugates thereof, preparation and uses

Inventors: Yong Zhang (West Windsor, NJ); Robert M. Borzilleri (Carversville, PA); Andrew J. Tebben (New Hope, PA); Erik M. Stang (Sterling, VA); Andrew F. Donnell (West Windsor, NJ); Gretchen M. Schroeder (Ewing, NJ); Heidi L. Perez (Ewing, NJ); Donna D. Wei (Belle Mead, NJ)
Assignee: Bristol-Myers Squibb Company
C07D498/22A61K31/5513A61K31/5517A61K47/48384A61K47/48569A61K47/48592A61K47/48615A61K47/48638A61K47/48715C07D519/00C07K16/30C07K16/3023C07K16/3046C07K16/3069
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Quick Facts
Patent No.
US 9,902,740
App. No.
15/606,512
Granted
Feb 27, 2018
Kind
B2
Abstract

Macrocyclic benzodiazepine dimers having a structure represented by formula I where A and B are independently according to formulae Ia or Ib and the other variables in formulae I, Ia, and Ib are as defined in the application. Such dimers are useful as anti-cancer agents, especially when used as the drug component in an antibody-drug conjugate (ADC).

Claims (1)

1. A compound having a structure represented by formula IIIa-11:

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 6, 2017
From: ZHANG, YONG; BORZILLERI, ROBERT M.; TEBBEN, ANDREW J.; STANG, ERIK M.; DONNELL, ANDREW F.; SCHROEDER, GRETCHEN M.; PEREZ, HEIDI L.; WEI, DONNA D.
To: BRISTOL-MYERS SQUIBB COMPANY
Reel/Frame 044039/0843 →
Continuity (3)
Continuation 15189388 · Jun 22, 2016
Provisional Application 62183350 · Jun 23, 2015
Related Publication 20170260205A1 · Sep 14, 2017