Peptides and combination of peptides for use in immunotherapy against ovarian cancer and other cancers
The present invention relates to peptides, proteins, nucleic acids and cells for use in immunotherapeutic methods. In particular, the present invention relates to the immunotherapy of cancer. The present invention furthermore relates to tumor-associated T-cell peptide epitopes, alone or in combination with other tumor-associated peptides that can for example serve as active pharmaceutical ingredients of vaccine compositions that stimulate anti-tumor immune responses, or to stimulate T cells ex vivo and transfer into patients. Peptides bound to molecules of the major histocompatibility complex (MHC), or peptides as such, can also be targets of antibodies, soluble T-cell receptors, and other binding molecules.
1. A peptide consisting of the amino acid sequence of SLMEPPAVLLL (SEQ ID NO: 1) in the form of pharmaceutical acceptable salt.
2. The peptide according to claim 1 , wherein said peptide has the ability to bind to a MEW class-I or II molecule, and wherein said peptide, when bound to said MEW, is capable of being recognized by CD4 and/or CD8 T cells.
3. The peptide according to claim 1 , wherein said peptide is part of a fusion protein, optionally comprising N-terminal amino acids of the HLA-DR antigen-associated invariant chain (Ii).
4. A kit comprising:
(a) a container comprising a pharmaceutical composition containing the peptide according to claim 1 ;
(b) optionally, a second container containing a diluent or reconstituting solution for the lyophilized formulation; and
(d) optionally, instructions for (i) use of the solution or (ii) reconstitution and/or use of the lyophilized formulation.
5. A pharmaceutical composition comprising
the peptide of claim 1 and a pharmaceutically acceptable carrier, and optionally, pharmaceutically acceptable excipients and/or stabilizers.
6. The peptide according to claim 1 , wherein said peptide is bound in an MHC complex.
7. An artificial antigen presenting cell (aAPC) comprising an MHC complex of the peptide according to claim 1 on the surface of the aAPC.