Crystalline form of a substituted quinoline compound and pharmaceutical compositions thereof
View Patent ↗The present invention relates to a crystalline form of N-(3-fluoro-4-((7-(2-hydroxy-2-methylpropoxy)quinolin-4-yl)oxy)phenyl)-1,5-dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazole-4-carboxamide p-toluenesulfonate, the process for preparing the crystalline form thereof, and the pharmaceutical compositions comprising the crystalline form thereof. This invention also relates to a method of using such a crystalline form and pharmaceutical compositions comprising the crystalline form thereof in the treatment of hyperproliferative diseases in mammals, especially in humans.
1. A crystalline form of a compound of formula (I):
wherein the crystalline form is form A having:
a) an X-ray powder diffraction pattern comprising peaks, in terms of 2θ, at about 8.29°, about 9.53°, about 11.11°, about 16.99°, about 18.75° and about 23.66°; or
b) an X-ray powder diffraction pattern comprising peaks, in terms of 2θ, at 8.29°±0.2°, 9.53°±0.2°, 11.11°±0.2°, 16.99°±0.2°, 18.75°±0.2° and 23.66°±0.2°; or
c) unit cell parameters substantially equal to the following:
(i) unit cell dimensions: a=8.7430 Å, b=12.8275 Å, c=16.1281 Å, a=96.689°, β=95.737°, γ=99.649°;
(ii) space group: P-1;
(iii) volume: 1757.82 Å 3 ;
(iv) Z: 2; and
(v) calculated density: 1.377 g/cm 3 .
2. The crystalline form of claim 1 having an X-ray powder diffraction pattern comprising peaks, in terms of 2θ, at about 8.29°, about 9.53°, about 11.11°, about 15.28°, about 16.99°, about 18.75°, about 19.14°, about 19.98°, about 20.42°, about 21.77°, about 22.02° and about 23.66°, or at 8.29°±0.2°, 9.53°±0.2°, 11.11°±0.2°, 15.28°±0.2°, 16.99°±0.2° 18.75°±0.2° 19.14°±0.2° 19.98°±0.2° 20.42°±0.2° 21.77°±0.2°, 22.02°±0.2° and 23.66°±0.2°.
3. The crystalline form of claim 1 , wherein the X-ray powder diffraction pattern comprising peaks, in terms of 2θ, at about 8.29°, about 9.53°, about 11.11°, about 12.67°, about 14.04°, about 15.28°, about 15.82°, about 16.99°, about 18.75°, about 19.14°, about 19.98°, about 20.42°, about 21.77°, about 22.02°, about 22.45°, about 22.65°, about 23.66°, about 26.85°, about 27.94° and about 28.34°, or at 8.29°±0.2°, 9.53°±0.2°, 11.11°±0.2°, 12.67°±0.2°, 14.04°±0.2°, 15.28°±0.2°, 15.82°±0.2°, 16.99°±0.2°, 18.75°±0.2° 19.14°±0.2° 19.98°±0.2° 20.42°±0.2° 21.77°±0.2° 22.02°±0.2° 22.45°±0.2°, 22.65°±0.2°, 23.66°±0.2°, 26.85°±0.2°, 27.94°±0.2° and 28.34°±0.2°.
4. The crystalline form of claim 1 , wherein the X-ray powder diffraction pattern is substantially in accordance with that shown in FIG. 2 .
5. The crystalline form of claim 1 , wherein the crystalline form is substantially pure.
6. A pharmaceutical composition comprising the crystalline form of claim 1 and a pharmaceutically acceptable excipient, carrier, vehicle or a combination thereof.
7. The pharmaceutical composition of claim 6 further comprising a therapeutic agent.
8. The pharmaceutical composition of claim 7 , wherein the therapeutic agent is melphalan, cyclophosphamide, ifosfamide, busulfan, carmustine, lomustine, streptozocin, cisplatin, carboplatin, oxaliplatin, dacarbazine, temozolomide, procarbazine, methotrexate, fluorouracil, cytarabine, gemcitabine, mercaptopurine, fludarabine, vinblastine, vincristine, vinorelbine, paclitaxel, docetaxel, topotecan, irinotecan, etoposide, trabectedin, dactinomycin, doxorubicin, epirubicin, daunorubicin, mitoxantrone, bleomycin, mitomycin, ixabepilone, tamoxifen, flutamide, gonadorelin analogues, megestrol, prednisone, dexamethasone, methylprednisolone, thalidomide, interferon alfa, leucovorin, sirolimus, temsirolimus, everolimus, afatinib, alisertib, amuvatinib, apatinib, axitinib, bosutinib, bortezomib, brivanib, cediranib, cabozantinib, crenolanib, crizotinib, dabrafenib, dacomitinib, danusertib, dasatinib, dovitinib, erlotinib, foretinib, ganetespib, gefitinib, ibrutinib, icotinib, imatinib, iniparib, lapatinib, lenvatinib, linifanib, linsitinib, masitinib, momelotinib, neratinib, nilotinib, niraparib, oprozomib, olaparib, pazopanib, pegaptanib, pictilisib, ponatinib, quizartinib, radotinib, regorafenib, rigosertib, rucaparib, ruxolitinib, saracatinib, saridegib, sorafenib, sunitinib, tasocitinib, telatinib, tivantinib, tivozanib, tofacitinib, trametinib, vandetanib, veliparib, vemurafenib, vismodegib, volasertib, alemtuzumab, bevacizumab, brentuximabvedotin, catumaxomab, cetuximab, denosumab, gemtuzumab, ipilimumab, nimotuzumab, ofatumumab, panitumumab, ramucirumab, rituximab, tositumomab, trastuzumab, idelalisib, duvelisib, gilteritinib, buparlisib, taselisib, copanlisib, voxtalisib, pilaralisib, sonolisib, perifosine, alectinib, ibrutinib, pertuzumab, nintedanib, cobimetinib, temsirolimus, sirolimus, pixantrone or a combination thereof.
9. A method of treating or lessening the severity of a proliferative disorder in a patient by administering to the patient with the crystalline form of claim 1 , wherein the proliferative disorder is gastric cancer, gastric adenocarcinoma, kidney cancer, renal cell carcinoma, liver cancer, hepatocellular carcinoma or lung cancer thereof.
10. A method of treating or lessening the severity of a proliferative disorder in a patient by administering to the patient with the pharmaceutical composition of claim 6 , wherein the proliferative disorder is gastric cancer, gastric adenocarcinoma, kidney cancer, renal cell carcinoma, liver cancer, hepatocellular carcinoma or lung cancer thereof.