Injectable liquid paracetamol formulation
The invention relates to an aqueous paracetamol solution for administration by means of infusion with a pH of between 4.5 and 6, containing at least one substance that can react with fenolates to produce the O-derivatives thereof or other co-ordination compounds. The injectable paracetamol solution has high stability, does not become colored over time and has a minimum impurity content.
1. An aqueous perfusion solution which solution has a pH of 5.0, wherein the aqueous perfusion solution consists of paracetamol, glucose, said glucose being in a concentration between 0.5% m/v and 3.0% m/v to stabilize said solution, a chelant and a buffering agent, and wherein the aqueous perfusion solution contains impurities no more than or equal to 0.13% resulting from paracetamol degradation when tested by storing in plastic for at least 89 hours at 70° C.
2. The aqueous perfusion solution according to claim 1 , which has been sterilized by heat.
3. The aqueous perfusion solution according to claim 1 , wherein the buffering agent is sodium acetate and/or sodium citrate.
4. The solution of claim 1 , wherein the aqueous perfusion solution is prepared without the removal of oxygen.