Cancer diagnosis method using respiratory gas
View Patent ↗A method for diagnosing cancer, comprises detecting volatile organic compounds (VOCs) contained specifically in exhaled breath of cancer patients, and more particularly, to a method for providing information for cancer diagnosis, which comprises a step of measuring whether ionized fragments of cancer-specific VOCs, which have molecular weights of (i) 69, (ii) 131 and (iii) 181, are present in exhaled breath gas collected from patients suspected of having cancer. Cancer can be early diagnosed with high sensitivity in a non-invasive manner by use of exhaled breath sampled from cancer patients. Thus, the cancer diagnosis method can diagnose cancer in a more cost-effective and rapid manner compared to conventional cancer diagnosis methods.
1. A method of detecting breast cancer or thyroid cancer in a patient, said method comprising:
obtaining an exhalation gas sample from a human patient;
ionizing volatile compounds in said exhalation gas sample to form ionized fragments of said volatile compounds;
detecting ionized fragments of molecular weights 69, 131, and 181 when present in said ionized fragments of said volatile compounds; and
when ionized fragments of molecular weight 69, 131, and 181 are detected in said ionized fragments of said volatile compounds, analyzing said volatile compounds corresponding to said ionized fragments of molecular weight 69, 131, and 181 via an information database to detect breast cancer or thyroid cancer-specific compounds selected from the group consisting of compounds (1)-(9) and mixtures thereof, when present in said volatile compounds,
wherein
compound (1) is perfluorodecanoic acid,
compound (2) is perfluoro-n-pentanoic acid,
compound (3) is perfluorononanoic acid,
compound (4) is perfluorooctanoic acid,
compound (5) is perfluoro-1-heptene,
compound (6) is perfluorocyclohexane,
compound (7) is 1H,1H-perfluoro-1-heptanol,
compound (8) is octafluorocyclobutane, and
compound (9) is perfluoro(methylcyclohexane).
2. The method according to claim 1 , further comprising corroborating said detecting cancer with tissue examination results.
3. The method according to claim 1 , wherein said detecting ionized fragments is performed by use of an instrument selected from the group consisting of electronic noses, gas chromatography (GC) instruments, and gas chromatography-mass spectrometry (GC-MS) instruments.
4. The method according claim 1 , wherein said detecting ionized fragments of molecular weights 69, 131, and 181 when present in said ionized fragments of said volatile compounds, further comprises detecting ionized fragments having molecular weight selected from the group consisting of molecular weights 51, 63, 79, 101, 113, 129, 147, 151, and 199, when present in said ionized fragments of said volatile compounds, as additional ionized fragments for detecting said cancer.
5. The method according to claim 1 , wherein said exhalation gas sample comprises an alveolar breath portion of an exhaled breath of said human patient.
6. The method according claim 1 , wherein said obtaining an exhalation gas sample from a human patient comprises collecting said exhalation gas sample in a breath sampling bag.