Method of treating fungal infection
A vaccine comprising Calnexin fragment and a method of using the vaccine to immunize a patient against fungi are disclosed. The Calnexin fragment may be either a full-length native version or a functionally equivalent version of full-length Calnexin.
1. A vaccine to immunize a patient against fungi, wherein the vaccine comprises a therapeutically effective amount of Calnexin peptide or Calnexin fragment, wherein the vaccine further comprises a therapeutically effective amount of an adjuvant, wherein the Calnexin peptide or Calnexin fragment consists of SEQ ID NO:1.
2. The vaccine of claim 1 , additionally comprising at least one of a stabilizer or a buffer.
3. A method of protecting a patient from fungal infection comprising of the steps of:
a. obtaining the vaccine of claim 1 , wherein the vaccine comprises a Calnexin fragment and
b. providing a therapeutically effective amount of the vaccine to a subject, wherein the subject is protected from fungal infection.
4. The method of claim 3 , wherein the fungi are either dimorphic fungi or non-dimorphic fungi.
5. The method of claim 4 , wherein the dimorphic fungi are selected from a group consisting of Histoplasma, Coccidiodes, Paracoccidioides, Penicillium, Blastomyces , and Sporothrix.
6. The method of claim 4 , wherein the non-dimorphic fungi are selected from a group consisting of Aspergillus, Pneumocystis, Magnaportha, Exophiala, Neuroaspora, Cryptococcus, Schizophyllum , and Candida.
7. The method of claim 3 , wherein the Calnexin fragment of step (a) is expressed and isolated from E. Coli.