IP Library › Granted Patent US 6,984,492
Granted Patent B2
US 6,984,492 · App. 10/656,781 · Granted Jan 10, 2006

Methods and compositions for treating herpes infections

View Patent ↗
Loading inventors, assignments & file history…
Monitor This Case
Get email alerts when status or documents change.
Order Certified Copies
Most orders are placed with the USPTO same day — all within 24 business hours.
Order via The Patent Place →
Pre-filled with this patent's details
Quick Facts
Patent No.
US 6,984,492
App. No.
10/656,781
Granted
Jan 10, 2006
Kind
B2
Abstract

A method of treatment or prophylaxis of herpes infections and associated disease states by administration of compositions comprising immunoglobulins. Methods comprising intravenous and topical administration of immunoglobulins are provided.

Claims (6)

1. A method of treatment of herpes simplex virus (HSV) infections in mammals, the method comprising, administering intravenously to a mammal an effective amount of a composition comprising monomeric IgA, dimeric IgA, and IgG prepared from pooled human plasma, wherein monomeric and dimeric IgA comprise at least from about 35% to about 55% of the total immunoglobulins present in the composition.

2. The method of claim 1 , wherein monomeric and dimeric IgA comprise at least from about 60% to about 80% of the total immunoglobulins present in the composition.

3. The method of claim 1 , wherein monomeric and dimeric IgA comprise at least from about 70% to about 95% of the total immunoglobulins present in the composition.

4. The method of claim 1 , wherein monomeric and dimeric IgA comprise at least about 60% of the total immunoglobulins present in the composition.

5. The method of claim 1 , wherein monomeric and dimeric IgA comprise at least about 80% of the total immunoglobulins present in the composition.

6. The method of claim 1 , wherein monomeric and dimeric IgA comprise at least 90% of the total immunoglobulins present in the composition.

Assignments (18)
RELEASE OF SECURITY INTEREST Recorded Nov 18, 2019
From: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
To: GRIFOLS SHARED SERVICES NORTH AMERICA, INC.; GRIFOLS THERAPEUTICS LLC (FORMERLY KNOWN AS GRIFOLS THERAPEUTICS, INC.); GRIFOLS BIOLOGICALS LLC (FORMERLY KNOWN AS GRIFOLS BIOLOGICALS, INC.); BIOMAT USA, INC.; GRIFOLS DIAGNOSTIC SOLUTIONS INC.; GRIFOLS WORLDWIDE OPERATIONS USA, INC.; GRIFOLS USA, LLC
Reel/Frame 051047/0153 →
RELEASE OF SECURITY INTEREST Recorded Nov 15, 2019
From: EUROPEAN INVESTMENT BANK
To: GRIFOLS SHARED SERVICES NORTH AMERICA, INC.; GRIFOLS THERAPEUTICS LLC (FORMERLY KNOWN AS GRIFOLS THERAPEUTICS, INC.; GRIFOLS BIOLOGICALS LLC (FORMERLY KNOWN AS GRIFOLS BIOLOGICALS, INC.); BIOMAT USA, INC.; GRIFOLS DIAGNOSTIC SOLUTIONS INC.; GRIFOLS WORLDWIDE OPERATIONS USA, INC.; GRIFOLS USA, LLC
Reel/Frame 051064/0021 →
RELEASE OF SECURITY INTEREST Recorded Nov 15, 2019
From: EUROPEAN INVESTMENT BANK
To: GRIFOLS SHARED SERVICES NORTH AMERICA, INC.; GRIFOLS THERAPEUTICS LLC (FORMERLY KNOWN AS GRIFOLS THERAPEUTICS, INC.); GRIFOLS BIOLOGICALS LLC (FORMERLY KNOWN AS GRIFOLS BIOLOGICALS, INC.); BIOMAT USA, INC.; GRIFOLS DIAGNOSTIC SOLUTIONS INC.; GRIFOLS WORLDWIDE OPERATIONS USA, INC.
Reel/Frame 051024/0722 →
SECURITY INTEREST Recorded Sep 7, 2018
From: GRIFOLS SHARED SERVICES NORTH AMERICA, INC.; GRIFOLS THERAPEUTICS LLC; GRIFOLS BIOLOGICALS LLC; BIOMAT USA, INC.; GRIFOLS DIAGNOSTIC SOLUTIONS INC.; GRIFOLS WORLDWIDE OPERATIONS USA, INC.; GRIFOLS USA, LLC
To: EUROPEAN INVESTMENT BANK, AS LENDER
Reel/Frame 047438/0836 →
SECURITY INTEREST Recorded Dec 5, 2017
From: GRIFOLS SHARED SERVICES NORTH AMERICA, INC.; GRIFOLS THERAPEUTICS INC.; GRIFOLS BIOLOGICALS INC.; BIOMAT USA, INC.; GRIFOLS DIAGNOSTIC SOLUTIONS.; GRIFOLS WORLDWIDE OPERATIONS USA, INC.
To: EUROPEAN INVESTMENT BANK, AS LENDER
Reel/Frame 044696/0846 →
SECURITY INTEREST Recorded Dec 5, 2017
From: GRIFOLS SHARED SERVICES NORTH AMERICA, INC.; GRIFOLS THERAPEUTICS INC.; GRIFOLS BIOLOGICALS INC.; BIOMAT USA, INC.; GRIFOLS DIAGNOSTIC SOLUTIONS.; GRIFOLS WORLDWIDE OPERATIONS USA, INC.; GRIFOLS USA, LLC
To: EUROPEAN INVESTMENT BANK, AS LENDER
Reel/Frame 044697/0725 →
SECURITY INTEREST Recorded Feb 7, 2017
From: GRIFOLS SHARED SERVICES NORTH AMERICA INC.; GRIFOLS THERAPEUTICS INC.; GRIFOLS BIOLOGICALS INC.; BIOMAT USA, INC.; GRIFOLS DIAGNOSTIC SOLUTIONS INC.; GRIFOLS WORLDWIDE OPERATIONS USA, INC.; GRIFOLS USA, LLC
To: BANK OF AMERICA, N.A., AS COLLATERAL AGENT
Reel/Frame 041651/0487 →
RELEASE OF SECURITY INTEREST Recorded Feb 6, 2017
From: DEUTSCHE BANK AG NEW YORK BRANK
To: GRIFOLS THERAPEUTICS INC.; GRIFOLS SHARED SERVICES NORTH AMERICA INC.; GRIFOLS DIAGNOSTIC SOLUTIONS INC.
Reel/Frame 041638/0527 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL/FRAME 26390/0193 Recorded Jan 25, 2017
From: DEUTSCHE BANK AG NEW YORK BRANCH
To: GRIFOLS, S.A.; GRIFOLS INC.; TALECRIS BIOTHERAPEUTICS, INC.
Reel/Frame 041494/0017 →
SECURITY AGREEMENT Recorded Feb 27, 2014
From: GRIFOLS INC.; GRIFOLS THERAPEUTICS INC.; GRIFOLS-CHIRON DIAGNOSTICS CORP.
To: DEUTSCHE BANK AG NEW YORK BRANCH, AS COLLATERAL AGENT
Reel/Frame 032367/0001 →
RELEASE OF SECURITY INTEREST Recorded Jun 3, 2011
From: WELLS FARGO FOOTHILL, INC.; WELLS FARGO BANK, N.A. (SUCCESSOR TO WACHOVIA BANK, N.A.)
To: TALECRIS BIOTHERAPEUTICS, INC.
Reel/Frame 026380/0966 →
SECURITY AGREEMENT Recorded Jun 3, 2011
From: GRIFOLS, S.A.; GRIFOLS INC.; TALECRIS BIOTHERAPEUTICS, INC.
To: DEUTSCHE BANK AG NEW YORK BRANCH
Reel/Frame 026390/0193 →
PATENT SECURITY AGREEMENT SECOND LIEN Recorded Mar 22, 2007
From: TALECRIS BIOTHERAPEUTICS HOLDINGS CORP.; TALECRIS BIOTHERAPEUTICS, INC.; PRECISION PHARMA SERVICES, INC.; TALECRIS PLASMA RESOURCES, INC.
To: MORGAN STANLEY SENIOR FUNDING, INC., AS THE ADMINISTRATIVE AGENT
Reel/Frame 019047/0276 →
PATENT SECURITY AGREEMENT FIRST LIEN Recorded Mar 22, 2007
From: TALECRIS BIOTHERAPEUTICS HOLDINGS CORP.; TALECRIS BIOTHERAPEUTICS, INC.; PRECISION PHARMA SERVICES, INC.; TALECRIS PLASMA RESOURCES, INC.
To: MORGAN STANLEY SENIOR FUNDING, INC., AS THE ADMINISTRATIVE AGENT
Reel/Frame 019047/0317 →
SECURITY AGREEMENT Recorded Mar 22, 2007
From: TALECRIS BIOTHERAPEUTICS HOLDINGS CORP.; TALECRIS BIOTHERAPEUTICS, INC.; PRECISION PHARMA SERVICES, INC.; TALECRIS PLASMA RESOURCES, INC.
To: WELLS FARGO FOOTHILL, INC., AS COLLATERAL AGENT; WACHOVIA BANK, NATIONAL ASSOCIATION, AS ADMINISTRATIVE AGENT
Reel/Frame 019047/0296 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 12, 2005
From: BAYER HEALTHCARE LLC
To: TALECRIS BIOTHERAPEUTICS, INC.
Reel/Frame 016519/0785 →
SECURITY INTEREST Recorded Apr 18, 2005
From: TALECRIS BIOTHERAPEUTICS HOLDINGS CORP.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 016087/0461 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 8, 2004
From: BETZ, ULRICH; RADTKE, KLAUS-PETER
To: BAYER HEALTHCARE, LLC
Reel/Frame 014249/0431 →