Granted Patent
B2
US 10,781,436 · App. 16/524,546 · Granted Sep 22, 2020
Penicillin-G acylases
Inventors:
Goutami Banerjee (Hayward, CA); Jie Yang (Foster City, CA); Xiyun Zhang (Fremont, CA); Erika M. Milczek (New York, NY); Melissa Ann Mayo (Foster City, CA); Stephan Jenne (Foster City, CA)
Assignee:
Codexis, Inc.
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Abstract
The present disclosure relates to engineered penicillin G acylase (PGA) enzymes having improved properties, polynucleotides encoding such enzymes, compositions including the enzymes, and methods of using the enzymes.
Claims (1)
1. An engineered penicillin G acylase capable of removing the A1/B1/B29 tri-phenyl acetate protecting groups from insulin to produce free insulin, wherein said penicillin G acylase consists of an asparagine at the amino acid residue that corresponds to position 484 of SEQ ID NO: 8.
Assignments (1)
SECURITY INTEREST
Recorded Feb 15, 2024
From: CODEXIS, INC.
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP, AS COLLATERAL AGENT
Reel/Frame 066600/0650 →
Continuity (4)
Provisional Application
62158118
· May 7, 2015
Cited By (1)