Granted Patent B2

US 12,295,881 · App. 16/972,085 · Granted May 13, 2025

Inventor: Yehuda Ivri (Newport Coast, CA)

Assignee: Bausch + Lomb Ireland Limited

A61F9/0008

Abstract

Claims (32)

1. A fluid delivery device, the device comprising:

(a) a fluid package comprising:

(i) a reservoir comprising an ophthalmic formulation; and

(ii) an aperture through which the ophthalmic formulation can be directed, the aperture having a diameter ranging from 200 to 350 μm;

(b) a pin member being in axial alignment with the aperture and engaging the reservoir; and

(c) an electromagnetic actuator configured to axially oscillate the pin member while imparting pressure fluctuations to the fluid to eject fluid from the reservoir through the aperture at a velocity in a range from 10 to 500 cm/sec, which results in minimal discomfort during topical ocular delivery;

wherein the electromagnetic actuator comprises an electromagnet and a permanent magnet in operational proximity to each other; and

wherein the permanent magnet is positioned at a first region of a cantilever beam and the electromagnetic actuator further comprises an anchor positioned at a second region of the cantilever beam and configured to transmit oscillatory displacement force to an external surface of the fluid package.

2. The fluid delivery device according to claim 1 , wherein the electromagnetic actuator imparts pressure fluctuations in the fluid by displacement induced on an external surface of the fluid package.

3. The fluid delivery device according to claim 1 , wherein the electromagnetic actuator oscillates at an audible frequency in a range from 20 to 20,000 Hz.

4. The fluid delivery device according to claim 3 , wherein the audible frequency ranges from 800 to 1200 Hz.

5. The fluid delivery device according to claim 1 , wherein the electromagnetic actuator is configured to operate at an oscillation amplitude ranging from 2 to 3 μm.

6. The fluid delivery device according to claim 1 , wherein the device is configured to eject fluid through the aperture as a stream having a velocity ranging from 50 to 150 cm/s.

7. The fluid delivery device according to claim 1 , further comprising an image-based alignment system configured to align fluid ejected through the aperture with a target ocular location.

8. The fluid delivery device according to claim 1 , wherein the fluid package and electromagnetic actuator are present in a housing.

9. The fluid delivery device according to claim 8 , wherein the housing comprises a cover positioned along the housing, wherein the cover is configurable between an open position, in which the aperture is exposed, and a closed position, in which the aperture is not exposed.

10. A method of delivering a fluid to a topical ocular location of a subject, the method comprising:

(a) aligning a fluid delivery device according to claim 1 with the topical ocular location; and

(b) activating the electromagnetic actuator to eject fluid from the reservoir through the aperture to the topical ocular location at a velocity which results in minimal discomfort during topical ocular delivery.

11. A kit comprising a fluid delivery device according to claim 1 .

12. A fluid delivery device, the device comprising:

(a) a fluid package comprising:

(i) a reservoir configured to hold a fluid; and

(ii) an aperture through which the fluid can be directed;

(b) a pin member being in axial alignment with the aperture and engaging the reservoir; and

(c) an electromagnetic actuator configured to axially oscillate the pin member while imparting pressure fluctuations to the fluid to eject the fluid from the reservoir through the aperture;

wherein the electromagnetic actuator comprises an electromagnet and a permanent magnet in operational proximity to each other; and

wherein the permanent magnet is positioned at a first region of a cantilever beam and the electromagnetic actuator further comprises an anchor positioned at a second region of the cantilever beam and configured to transmit oscillatory displacement force to an external surface of the fluid package.

13. The fluid delivery device according to claim 12 , wherein the fluid package and actuator are present in a housing.

14. The fluid delivery device according to claim 13 , wherein the housing comprises a cover positioned along the housing, wherein the cover is configurable between an open position, in which the aperture is exposed, and a closed position, in which the aperture is not exposed.

15. The fluid delivery device according to claim 12 , further comprising an image-based alignment system configured to align fluid ejected through the aperture with a target ocular location.

16. The fluid delivery device according to claim 15 , where the image-based alignment system is a concave mirror.

Assignments (8)

Continuity (2)

References Cited (352)