IP Library Granted Patent US 12,290,472
Granted Patent B2
US 12,290,472 · App. 17/692,991 · Granted May 6, 2025

Hydrodynamically actuated preservative free dispensing system

Inventor: Yehuda Ivri (Newport Coast, CA)
Assignee: BAUSCH + LOMB IRELAND LIMITED
A61F9/0026
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Quick Facts
Patent No.
US 12,290,472
App. No.
17/692,991
Granted
May 6, 2025
Kind
B2
Abstract

Multi-dose preservative-free ocular fluid delivery devices are provided. The fluid delivery device includes a fluid dispensing system and a fluid package for storing a liquid therein and supplying said liquid to the dispensing system. The dispensing system comprises an elongated chamber which includes a check valve which defines a frontal closure to the chamber. The valve is normally closed and hermetically seals the chamber. The dispenser includes a vibration motor that induces oscillations to the chamber and to the fluid within. The oscillations of the chamber impart momentum to the fluid stored in the chamber which in turn imparts force that cyclically opens the valve to dispense streams or liquid droplets. Fluid is dispensed only when the motor oscillates while otherwise the valve is hermetically closed. Preferably, the fluid package and check valve are included in a disposable reservoir assembly.

Claims (17)

1. Apparatus for delivering a liquid to an eye of a patient, the apparatus comprising:

a) a reservoir assembly; and

b) an actuator assembly;

c) wherein the reservoir assembly includes a reservoir configured to contain the liquid and a check valve, wherein the check valve includes an aperture through which the liquid can be dispensed and a pin member that engages with the aperture to provide a normally closed configuration of the check valve;

d) wherein the actuator assembly includes an actuator configured to provide a mechanical excitation to the reservoir assembly that generates a corresponding hydrodynamic excitation of the liquid;

e) wherein the hydrodynamic excitation of the liquid ejects the liquid through the aperture by elastically deforming the aperture to open the check valve; and

f) wherein the actuator assembly can be connected to and disconnected from the reservoir assembly by a user, whereby the reservoir assembly is disposable.

2. The apparatus of claim 1 , further comprising an optical sensor configured to provide a measurement of a frequency of the mechanical excitation.

3. The apparatus of claim 1 , wherein a mechanical connection between the actuator assembly and the reservoir assembly is provided by a first permanent magnet disposed on the actuator assembly and a second permanent magnet disposed on the reservoir assembly.

4. The apparatus of claim 1 , wherein a mechanical connection between the actuator assembly and the reservoir assembly is provided by a pin disposed on the actuator assembly configured to engage with a hole disposed on the reservoir assembly.

5. The apparatus of claim 1 , wherein a mechanical connection between the actuator assembly and the reservoir assembly is provided by a ridge disposed on the actuator assembly configured to engage with a slot disposed on the reservoir assembly.

6. The apparatus of claim 1 , wherein the actuator includes a vibration motor having an eccentric mechanical load relative to an axis of rotation of the vibration motor.

7. The apparatus of claim 6 , wherein the reservoir assembly is supported by a flexible member, whereby operation of the vibration motor generates the hydrodynamic excitation of the liquid by oscillating the reservoir assembly.

8. The apparatus of claim 1 , wherein the reservoir includes a vent.

9. The apparatus of claim 8 , wherein the vent includes a filter configured to ensure that air that enters the reservoir is sterile.

10. The apparatus of claim 1 , further comprising a concave mirror configured to provide an in-focus image of the patient's eye to the patient when the apparatus is positioned properly to deliver the liquid to the eye of the patient.

11. The apparatus of claim 1 , wherein the actuator assembly further includes one or more components selected from the group consisting of: battery compartments, batteries, wireless communication devices, wired communication ports, and actuation switches.

Assignments (8)
ASSIGNMENT OF SECURITY INTEREST IN PATENTS PREVIOUSLY RECORDED AT REEL/FRAME (066694/0131) Recorded Aug 14, 2025
From: CITIBANK, N.A., AS RESIGNING AGENT
To: JPMORGAN CHASE BANK, N.A., AS SUCCESSOR AGENT
Reel/Frame 072460/0655 →
PATENT SECURITY AGREEMENT Recorded Jul 1, 2025
From: BAUSCH & LOMB INCORPORATED; ALDEN OPTICAL LABORATORIES, INC.; BAUSCH + LOMB IRELAND LIMITED
To: CITIBANK, N.A., AS NOTES COLLATERAL AGENT
Reel/Frame 071773/0871 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Feb 29, 2024
From: BAUSCH + LOMB IRELAND LIMITED
To: CITIBANK, N.A., AS NOTES COLLATERAL AGENT
Reel/Frame 066707/0684 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Feb 27, 2024
From: BAUSCH + LOMB IRELAND LIMITED
To: CITIBANK, N.A., AS COLLATERAL AGENT
Reel/Frame 066694/0131 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 9, 2023
From: NOVARTIS AG
To: BAUSCH + LOMB IRELAND LIMITED
Reel/Frame 065531/0583 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNMENT AGREEMENT PREVIOUSLY RECORDED ON REEL 062116 FRAME 0917. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jul 10, 2023
From: KEDALION THERAPEUTICS, INC.
To: NOVARTIS AG
Reel/Frame 064237/0507 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 13, 2022
From: KEDALION THERAPEUTICS, INC.
To: NOVARTIS AG
Reel/Frame 062116/0917 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 21, 2022
From: IVRI, YEHUDA
To: KEDALION THERAPEUTICS, INC.
Reel/Frame 059327/0436 →
Continuity (6)
Continuation In Part 17509383 · Oct 25, 2021
Continuation In Part 17233105 · Apr 16, 2021
Provisional Application 63212545 · Jun 18, 2021
Provisional Application 63159830 · Mar 11, 2021
Provisional Application 63011808 · Apr 17, 2020
Related Publication 20220192874A1 · Jun 23, 2022
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