METHODS AND PRODUCTS FOR REMOVAL OF URACIL CONTAINING POLYNUCLEOTIDES

Inventors: SOSKINE MIKHAEL [FR], CHUA PUAY SUAN JASMINE [FR], LOFTIE-EATON WESLEY [FR], CHAMPION ELISE [FR]

Applicant: DNA SCRIPT [FR]

Published April 25, 2024 View on Espacenet ↗

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Abstract

The present invention relates to the use of a DNA glycosylase enzyme for removing or blocking uracil containing polynucleotides, and methods incorporating the use of such enzymes to remove or block uracil containing polynucleotides from polynucleotide containing compositions, particularly in methods of template-free DNA synthesis The present invention further relates to methods of tethering polynucleotides to a surface or molecule using a DNA glycosylase enzyme, the resulting products therefrom, and to modified DNA glycosylase enzymes.

Inventors

SOSKINE MIKHAEL [FR]

CHUA PUAY SUAN JASMINE [FR]

LOFTIE-EATON WESLEY [FR]

CHAMPION ELISE [FR]

Applicants

DNA SCRIPT [FR]

IPC Classification

C12N 9/ 24 A I C12P 19/ 34 A I