Sonic treatment to selectively reduce the void volume of sintered polymers
View Patent ↗The present invention provides a method of sonic treatment to selectively reduce the void volume of a sintered polymer such as porous high density polyethylene (HDPE). The invention also provides a method and an article of manufacture for receiving a liquid sample, where a first portion of the sintered polymer (1a) overlies a solid surface (4a) and a second portion of the polymer (1b) overlies a window (4b). Sonic treatment of the sintered polymer reduces the void volume of the first portion (1a) compared to the second portion (1b). As a result, a liquid sample applied to the polymer will preferentially migrate through the second portion (1b), rather than through the first portion (1a). When the article of manufacture is used to analyze a liquid sample such as blood, less sample is required because of the preferential migration in the sonically treated sintered polymer.
1. An article of manufacture for receiving a liquid sample, comprising a solid having a window and a sintered polymer, wherein a first portion of the polymer overlies the window and a second portion of the polymer overlies the surface of the solid without the window; and wherein the polymer is sonically treated; whereby the void volume in the first portion is less than the void volume in the second portion.
2. The article of claim 1 , further comprising a means for adhering the sintered polymer to the solid.
3. The article of claim 1 , wherein the liquid sample is selected from the group consisting of blood, serum, plasma, sweat, tears, saliva, semen, cerebrospinal fluid, sputum, urine and cervical mucus or swabbings.
4. The article of claim 3 , wherein the liquid sample is blood.
5. The article of claim 1 , wherein the surface of the sintered polymer is hydrophilic.
6. The article of claim 1 , wherein the sintered polymer further comprises a coating of detergent.
7. The article of claim 6 , wherein the sintered polymer further comprises a coagulant.
8. The article of claim 1 , further comprising a means for reacting with a liquid sample.
9. The article of claim 8 , wherein the reacting means is positioned between the sintered polymer and the window of the solid.
10. The article of claim 8 , wherein the means for reacting is a reaction layer.
11. The article of claim 10 , wherein the reaction layer comprises a reagent that reacts with glucose.
12. The article of claim 11 , wherein the reagent is N-ethyl-N-2-hydroxy-3-sulfopropyl-3,5-dimethylaniline (MAOS).
13. A method for receiving a liquid sample, comprising the steps of applying a liquid sample to an article of claim 1 on the side of the sintered polymer opposite the window and allowing the sample to migrate toward the window, whereby the sample does not migrate away from the window due to the reduced void volume in the first portion.
14. The method of claim 13 , wherein the article further comprises a means for adhering the sintered polymer to the solid.
15. The method of claim 13 , wherein the liquid sample is selected from the group consisting of blood, serum, plasma, sweat, tears, saliva, semen, cerebrospinal fluid, sputum, urine and cervical mucus or swabbings.
16. The method of claim 15 , wherein the liquid sample is blood.
17. The method of claim 13 , wherein the surface of the sintered polymer is hydrophilic.
18. The method of claim 13 , wherein the sintered polymer further comprises a coating of detergent.
19. The method of claim 18 , wherein the sintered polymer further comprises a coagulant.
20. The method of claim 13 , wherein the article further comprises a means for reacting with a liquid sample.
21. The method of claim 20 , wherein the reacting means is positioned between the sintered polymer and the window of the solid.
22. The method of claim 20 , wherein the means for reacting is a reaction layer.
23. The method of claim 22 , wherein the reaction layer comprises a reagent that reacts with glucose.
24. The method of claim 23 , wherein the reagent is N- ethyl - N - 2 - hydroxy - 3 - sylfopropyl - 3 , 5 - dimethylaniline ( MAOS ).