IP Library › Granted Patent US 7,102,018
Granted Patent B2
US 7,102,018 · App. 10/369,560 · Granted Sep 5, 2006

Intermediates and improved processes for the preparation of neplanocin A

Assignee: Chisso Corporation
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Quick Facts
Patent No.
US 7,102,018
App. No.
10/369,560
Granted
Sep 5, 2006
Kind
B2
Abstract

Intermediate compounds, including 2-(t-butyldimethylsilyloxymethyl)-3,4-[(dimethylmethylene)dioxy]-5-hydroxy-tricyclo[5.2.1.0 2,6 ]dec-8-ene, which are useful for the synthesis of neplanocin A having strong antitumor activity. Improved processes for the preparation of neplanocin A, starting from optically active 2-hydroxymethyl-5-hydroxy-tricyclo[5.2.1.0 2,6 ]deca-3,8-diene and via a key step comprising a retro-Diels-Alder reaction of the above intermediate.

Claims (3)

1. A compound of formula (6)

wherein Y is a protecting group.

2. A compound of claim 1 wherein Y is t-butyldimethylsilyl.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 27, 2011
From: CHISSO CORPORATION
To: JNC CORPORATION
Reel/Frame 026187/0940 →
Priority Claims (1)
JP 10-158687 · May 25, 1998 · national
Continuity (6)
Division 1036951000 · Feb 21, 2003
Division 1036953200 · Feb 21, 2003
Division 1036968600 · Feb 18, 2003
Division 0984935600 · May 7, 2001
Division 0931843500 · May 25, 1999
Related Publication 20030162281A1 · Aug 28, 2003