Nutritional composition against side effects of chemotherapy or radiotherapy

1. A nutritional composition, wherein said nutritional composition has an energy content between 1.4-1.6 kcal per ml of said composition and comprises:

a) a lipid source,

b) a carbohydrate source,

c) a protein source that provides from 20 to 30% of the energy of the composition and comprises casein, whey and TGF-β; and

d) free glutamine in a quantity such as to provide from 2 to 15% of the energy of said composition; and

wherein the remainder of said nutritional composition comprises 40 to 80% by weight of casein, from 60-20% by weight of whey; and from 0.5 to 20 μg of TGF-β3 per 100 kcal of the composition.

2. The composition according to claim 1 , wherein said TGF-β is TGF β2 provided by acid casein and wherein said casein contains at least enough acid casein to provide the TGF-β2.

3. The composition according to claim 2 , wherein TGF-β2 is from 1.5 to 4 μg per 100 kcal of the composition.

4. The composition according to claim 1 , wherein the free glutamine provides from 5 to 10% of the energy of the composition.

5. The composition according to claim 1 , wherein the lipid source provides from 25 to 45% of the energy of the composition.

6. The composition according to claim 1 , wherein the lipid source comprises, in percent by weight of the lipid source, from 30 to 70% of medium chain triglycerides.

7. The composition according to claim 1 , wherein the carbohydrate source provides from 25 to 55% of the energy of the composition.

8. A method for alleviating and/or reducing side effects of chemotherapy and/or radiotherapy in a patient comprising:

administering to said patient an effective amount of a nutritional composition having an energy content between 1.4-1.6 kcal per ml of said composition, wherein said nutritional composition comprises:

a) a lipid source;

b) a carbohydrate source;

c) a protein source that provides from 20 to 30% of the energy of the composition and comprises casein, whey and TGF-β; and

d) free glutamine in a quantity such as to provide from 2 to 15% of the energy of said composition,

wherein the remainder of said nutritional composition comprises 40 to 80% by weight of casein, from 60-20% by weight of whey; and from 0.5 to 20 μg of TGF-β per 100 kcal of the composition.

9. The method of claim 8 , wherein said side effects of chemotherapy and/or radiotherapy are selected from the group consisting of diarrhoea, stomatitis, mucositis and increased intestinal permeability.

10. A method for providing nutrition to a patient suffering from cancer during periods of chemotherapy and/or radiotherapy treatment and immediately after such periods of treatment comprising:

administering to said patient an effective amount of a nutritional composition having an energy content between 1.4-1.6 kcal per ml of said composition, wherein said nutritional composition comprises:

a) a lipid source;

b) a carbohydrate source;

c) a protein source that provides from 20 to 30% of the energy of the composition and comprises casein, whey and TGF-β; and

d) free glutamine in a quantity such as to provide from 2 to 15% of the energy of said composition,

wherein the remainder of said nutritional composition comprises 40 to 80% by weight of casein, from 60-20% by weight of whey; and from 0.5 to 20 μg of TGF-β per 100 kcal of the composition.

11. A nutritional composition, wherein said nutritional composition has an energy content of 1.2 to 2 kcal per ml of said composition and comprises:

a lipid source,

a carbohydrate source,

a protein source that provides from 20 to 30% of the energy of the composition and comprises casein, whey and TGF-β; and

free glutamine in a quantity such as to provide from 2 to 15% of the energy of said composition; and

wherein the remainder of said nutritional composition comprises 40 to 80% by weight of casein, from 60-20% by weight of whey; and from 0.5 to 20 μg of TGF-βper 100 kcal of said composition.