Treatment of actinomyces naeslundii-related diseases with exogenous lactic bacteria strains
View Patent ↗A lactic bacteria strain that is exogenous to the oral microflora is selected for its ability to adhere the pellicle of the teeth and to produce a growth inhibition factor. This strain is used for the preparation of a composition intended for reducing dental plaque and for treating or preventing root caries and other diseases related to Actinomyces naeslundii in mammals.
1. A composition for maintaining mammal mouth health by reducing Actinomyces naeslundii colonization therein, the composition comprising at least one biologically pure lactic bacteria strain selected from the group consisting of the biologically pure strains CNCM I-1984, CNCM I-1985, CNCM I-1986, and CNCM I-1987, wherein the strain is exogenous to oral microflora, said strain is selected for its ability to adhere to teeth pellicle and to produce an Actinomyces naeslundii growth inhibition factor, and which is present in an amount sufficient to reduce or inhibit the colonization of Actinomyces naeslundii , thus maintaining mouth health in a mammal that consumes the composition.
2. The composition according to claim 1 , further comprising a bactenocin.
3. The composition according to claim 1 , comprising at least 10 4 -10 9 cfu/g of the lactic bacteria strain.
4. A method of treating Actinomyces naeslundii -related diseases in mammals, which comprises administering to a mammal a composition according to claim 1 .
5. The method according to claim 4 , wherein the at least one bacteria strain is administered for reducing dental plaque or for treating root caries or infections.
6. The method according to claim 4 , wherein the composition is administered by feeding it to the mammal.
7. A method of treating Actinomyces naeslundii -related diseases in mammals, the method comprising administering to a mammal at least one lactic bacteria strain selected from the group consisting of the strains CNCM I-1984, CNCM I-1985, CNCM I-1986, and CNCM I-1987, wherein the strain is selected for its ability to produce an Actinomyces naeslundii growth inhibition factor in an amount sufficient to reduce or inhibit the colonization of Actinomyces naeslundii , thus treating such diseases in a mammal that consumes the composition.
8. The method according to claim 7 , wherein the at least one bacteria strain is administered for reducing dental plaque or for treating root caries or infections.
9. A dentifrice composition for maintaining mammal mouth health by reducing Actinomyces naeslundii colonization therein, the composition comprising at least one lactic bacteria strain selected from the group consisting of the strains CNCM I-1984, CNCM I-1985, CNCM I-1986, and CNCM I-1987, wherein the strain is exogenous to oral microflora, said strain is selected for its ability to adhere to teeth pellicle and to produce an Actinomyces naeslundii growth inhibition factor, and which is present in an amount sufficient to reduce or inhibit the colonization of Actinomyces naeslundii , thus maintaining mouth health in a mammal that consumes the composition.
10. A method of reducing dental plaque or of treating root caries or infections caused by Actinomyces naeslundii in mammals, the method comprising administering to a mammal in need of such treatment a lactic bacteria strain selected from the group consisting of the strains CNCM I-1984, CNCM I-1985, CNCM I-1986, and CNCM I-1987, wherein the strain is exogenous to the oral microflora, is selected for its ability to adhere to teeth pellicle and to produce an Actinomyces naeslundii growth inhibition factor, and is administered in an amount sufficient to reduce or inhibit the colonization of Actinomyces naeslundii , thus reducing dental plaque or treating root caries or infections in the mammal.
11. The method according to claim 10 , wherein the lactic bacteria strain is of dairy origin.
12. The method according to claim 10 , wherein the bacteria strain is administered to the mammal in an edible composition.
13. The method according to claim 12 , wherein the edible composition contains at least 10 4 to 10 9 cfu/g of the lactic bacteria strain.
14. The method according to claim 10 , wherein the lactic bacteria strain is administered in combination with a bacteriocin.
15. The method according to claim 10 , wherein the mammal is a human.
16. The method according to claim 15 , wherein the human is over 40 years old.
17. A method of making a composition that is effective for reducing dental plaque or of treating root caries or infections caused by Actinomyces naeslundii in mammals, the method comprising incorporating in an edible composition a lactic bacteria strain selected from the group consisting of the strains CNCM I-1984, CNCM I-1985, CNCM I-1986, and CNCM I-1987, wherein the strain is exogenous to the oral microflora, is selected for its ability to adhere to teeth pellicle and to produce an Actinomyces naeslundii growth inhibition factor, and is present in an amount sufficient to reduce or inhibit the colonization of Actinomyces naeslundii , thus reducing dental plaque or treating root caries or infections in a mammal that consumes the composition.