Treating wasting disorders with selective androgen receptor modulators
View Patent ↗This invention provides: 1) a method of treating a subject suffering from a muscle wasting disorder; 2) a method of preventing a muscle wasting disorder in a subject; 3) a method of treating, preventing, suppressing, inhibiting or reducing muscle loss in a subject suffering from a muscle wasting disorder; 4) a method of treating, preventing, inhibiting, reducing or suppressing muscle wasting in a subject suffering from a muscle wasting disorder; and/or 5) a method of treating, preventing, inhibiting, reducing or suppressing muscle protein catabolism in a subject suffering from a muscle wasting disorder, by administering to the subject a selective androgen receptor modulator (SARM) and/or an analog, derivative, isomer, metabolite, pharmaceutically acceptable salt, pharmaceutical product, hydrate, N-oxide, prodrug, polymorph, impurity or crystal of said SARM compound, or any combination thereof.
1. A method of treating a human subject suffering from a wasting disorder, or suppressing or reducing the incidence of a wasting disorder in a subject, comprising the step of administering to said subject a selective androgen receptor modulator (SARM) compound of formula XX:
and/or its isomer, pharmaceutically acceptable salt or any combination thereof.
2. The method of claim 1 , wherein said wasting disorder is due to a pathology, illness, disease or condition.
3. The method of claim 2 , wherein said pathology, illness, disease or condition is neurological, infectious, chronic or genetic.
4. The method of claim 2 , wherein said pathology, illness, disease or condition is cachexia, malnutrition, leprosy, tuberculosis, diabetes, renal disease, chronic obstructive pulmonary disease, cancer, end stage renal failure, emphysema, osteomalacia, HIV infection, AIDS, andropause, frailty or cardiomyopathy.
5. The method according to claim 1 , wherein said wasting disorder is age-associated or is due to chronic lower back pain, burns, central nervous system injury or damage, peripheral nerve injury or damage, spinal cord injury or damage, chemical injury or damage, or alcoholism.
6. The method of claim 1 , wherein said wasting disorder is a muscle wasting disorder.
7. The method of claim 6 , wherein said muscle wasting disorder is due to a muscular dystrophy, a muscular atrophy, an X-linked spinal-bulbar muscular atrophy, or sarcopenia.
8. The method according to claim 6 , wherein said muscle wasting disorder is a disuse deconditioning-associated muscle wasting disorder.
9. The method according to claim 6 , wherein said muscle wasting disorder is a chronic muscle wasting disorder.
10. The method according to claim 1 , wherein said administering comprises administering a composition comprising said SARM, and/or its isomer, pharmaceutically acceptable salt, or any combination thereof, and a pharmaceutically acceptable carrier.
11. The method according to claim 10 , wherein said administering comprises intravenously, intraarterially, or intramuscularly injecting to said subject said pharmaceutical composition in liquid form; subcutaneously implanting in said subject a pellet containing said pharmaceutical composition; orally administering to said subject said pharmaceutical composition in a liquid or solid form; or topically applying to the skin surface of said subject said pharmaceutical composition.
12. The method according to claim 10 , wherein said pharmaceutical composition is a pellet, a tablet, a capsule, a solution, a suspension, an emulsion, an elixir, a gel, a cream, a suppository or a parenteral formulation.