Composition comprising free amino acids
View Patent ↗A composition is described that can be used in prevention or treatment of patients having impaired gastro-intestinal tract function. The composition comprises free amino acids including about 9.0% to about 17.0% glutamic acid. Methods of treatment of impaired gastro-intestinal tract function are described.
1. A method of providing nutrition to an individual having impaired gastro-intestinal tract function, the method comprising:
administering to an individual having impaired gastro-intestinal tract function a therapeutically effective amount of a composition comprising free amino acids and 9.0% to about 17.0% glutamic acid by weight of total amino acids of the composition, wherein the composition has no glutamine, and wherein the composition comprises methionine in an amount from about 2.4 to about 3.2 g/100 g total amino acids.
2. The method according to claim 1 , wherein the composition comprises cysteine in an amount from about 2.3 to about 10 g.
3. The method according to claim 1 , wherein the impaired gastro-intestinal function is due to Crohn's disease, cystic fibrosis, HIV/AIDS, cancer, post surgery complications, intractable diarrhoea, short bowel syndrome, cerebral palsy or gastric reflux.
4. The method according to claim 1 , wherein the composition is in a ready to use form.
5. The method according to claim 1 , wherein the composition comprises arginine in an amount from 2.3% to 7% total amino acids by weight.
6. The method according to claim 1 , wherein the composition comprises aspartic acid.
7. The method according to claim 1 , wherein the composition comprises leucine.
8. The method according to claim 1 , wherein the composition comprises threonine.
9. The method according to claim 1 , wherein the composition comprises proline.
10. The method according to claim 1 , wherein the composition comprises tryptophan.
11. The method according to claim 1 , wherein the composition comprises serine.
12. The method of claim 1 , wherein the composition comprises lysine.
13. The method of claim 1 , wherein the composition comprises branched amino acids.
14. The method of claim 1 , wherein the composition further comprises at least one amino acid in the following amounts selected from the group consisting of:
Amount (g/100 g
Amino Acids
total amino acids)
Ile
5.7-7.0
Leu
10.8-14.0
Lys
6.5-10.0
Phe
3.2-.2
Thr
5.0-12.0
Trp
1.7-2.2
Val
5.5-7.0
His
1.8-2.3
Arg
2.3-7.0
Pro
5.0-6.0
Gly
1.9-3.2
Ala
1.5-5.1
Ser
5.0-16.0
Tyr
1.0-4.0
Cys
2.3-10.0
Asp
4.0-15.0
Aromatics
4.2-11.2
Sulphur containing
4.7-13.2
BCAA
22.0-28.0.
15. The method of claim 1 , wherein the composition comprises:
Amount (g/100 g
Amino Acids
total amino acids)
Ile
5.7-7.0
Leu
10.8-14.0
Lys
6.5-10.0
Met
2.4-3.2
Phe
3.2-.2
Thr
5.0-12.0
Trp
1.7-2.2
Val
5.5-7.0
His
1.8-2.3
Arg
2.3-7.0
Pro
5.0-6.0
Gly
1.9-3.2
Ala
1.5-5.1
Ser
5.0-16.0
Tyr
1.0-4.0
Cys
2.3-10.0
Asp
4.0-15.0
Glu
9.0-17.0
Aromatics
4.2-11.2
Sulphur containing
4.7-13.2
BCAA
22.0-28.0.