Selective androgen receptor modulators and method of use thereof
View Patent ↗This invention provides SARM compounds and uses thereof in treating a variety of diseases or conditions in a subject, including, inter-alia, a muscle wasting disease and/or disorder or a bone-related disease and/or disorder.
1. A SARM compound represented by the structure of formula (III):
and/or its isomer, pharmaceutically acceptable salt, or any combination thereof.
2. A composition comprising the SARM compound of claim 1 , and/or its isomer, or any combination thereof; and a suitable carrier or diluent.
3. A composition comprising the SARM compound of claim 1 , and/or its isomer, or any combination thereof, and/or a pharmaceutically acceptable salt thereof; and a suitable carrier or diluent.
4. A method of binding a SARM compound to an androgen receptor, comprising the step of contacting the androgen receptor with the SARM compound of claim 1 and/or its isomer, pharmaceutically acceptable salt, or any combination thereof, in an amount effective to bind the SARM compound to the androgen receptor.
5. A method of hormone therapy comprising the step of contacting an androgen receptor of a subject with the SARM compound of claim 1 and/or its isomer, pharmaceutically acceptable salt, or any combination thereof, in an amount effective to effect a change in an androgen-dependent condition.
6. A method of treating a subject suffering from prostate cancer, comprising the step of administering to said subject the SARM compound of claim 1 and/or its isomer, pharmaceutically acceptable salt, or any combination thereof, in an amount effective to treat prostate cancer in said subject.
7. A method of delaying the progression of prostate cancer in a subject suffering from prostate cancer, comprising the step of administering to said subject the SARM compound of claim 1 and/or its isomer, pharmaceutically acceptable salt, or any combination thereof, in an amount effective to delay the progression of prostate cancer in said subject.