Stable and bioavailable compositions of isomers of carotenoids for skin and hair
View Patent ↗Compositions that provide health benefits and methods regarding same are presented. In an embodiment, the present invention provides a primary composition comprising at least one carotenoid-containing material, enriched in Z isomers of the carotenoid compound. For example, the carotenoid-containing material contains by weight a greater percentage of an isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof than of 13-Z isomer.
1. A stable primary composition comprising at least one carotenoid-containing material is an oleoresin comprising a carotenoid content from 0.05% to 50% by weight, is enriched in Z isomers of the carotenoid compound, and comprises by weight of a total carotenoid content a greater percentage of an isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof than of a 13-Z isomer, and contains more than 30% by weight of the total carotenoid content of the isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof, and less than 10% by weight of the total carotenoid content of the 13-Z isomer, and the Z:E isomer ratio of the carotenoid compound is between 20:80 and 95:5.
2. The primary composition of claim 1 , comprising a content in E isomer that is not greater than 60% of the total carotenoid content.
3. The primary composition of claim 1 , wherein the Z isomers of the carotenoid compound are present in an amount effective to increase the bioavailability and/or bioefficacy of the carotenoid compound.
4. The primary composition of claim 1 , wherein the carotenoid compound is selected from the group consisting of lycopene, carotenes, zeaxanthine, astaxanthine, β-cryptoxanthin, capsanthine, canthaxanthine, lutein, phytofluene, phytoene and combinations thereof.
5. The primary composition of claim 1 , wherein the Z/E isomer ratio of the carotenoid compound is from 30:70 to 90:10.
6. The primary composition of claim 1 , wherein the composition is in a form selected from the group consisting of liquid, gel and powder.
7. The primary composition of claim 1 , wherein the isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof comprises 5-Z isomer.
8. The primary composition of claim 1 , wherein the isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof comprises 9-Z isomer.
9. The primary composition of claim 1 , wherein the isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof comprises both 5-Z and 9-Z isomers.
10. The primary composition of claim 1 , wherein the amount of the 13-Z isomer is less than 3% by weight of the total carotenoid content.
11. An oral composition comprising between about 10 and 50% by weight of a primary composition comprising at least one carotenoid-containing material in a form selected from the group consisting of an extract, a concentrate and an oleoresin, enriched in Z isomers of the carotenoid compound, the carotenoid-containing material comprises by weight of a total carotenoid content a greater percentage of an isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof than of a 13-Z isomer, and contains more than 30% by weight of the total carotenoid content of the isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof, and less than 10% by weight of the total carotenoid content of the 13-Z isomer, and the Z:E isomer ratio of the carotenoid compound is between 20:80 and 95:5.
12. A stable primary composition comprising at least one carotenoid-containing material in a form selected from the group consisting of an extract, a concentrate and an oleoresin, enriched in Z isomers of the carotenoid compound, the carotenoid-containing material comprises by weight of a total carotenoid content a greater percentage of an isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof than of a 13-Z isomer, and contains more than 30% by weight of the total carotenoid content of the isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof, and less than 10% by weight of the total carotenoid content of the 13-Z isomer, and the Z:E isomer ratio of the carotenoid compound is between 20:80 and 95:5, wherein the amount of the isomer selected from the group consisting of 5-Z, 9-Z and combinations thereof is more than 50% by weight of the total carotenoid content.