Phosphonate compounds
View Patent ↗The present invention relates to phosphonate compounds, compositions containing them, processes for obtaining them, and their use for treating a variety of medical disorders, e.g., osteoporosis and other disorders of bone metabolism, cancer, viral infections, and the like.
1. An antiviral compound having the following structure:
or a pharmaceutically acceptable salt thereof.
2. A pharmaceutical composition comprising an effective amount of the antiviral compound of
in combination with a pharmaceutically acceptable carrier.
3. The pharmaceutical composition of claim 2 is in a solid dosage form.
4. The pharmaceutical composition of claim 2 is in a capsule, tablet, aerosol, solution, suspension, or in a topical formulation.
5. A method for the treatment of a viral disease comprising administering an effective amount of the antiviral compound having the structure of
or a pharmaceutically acceptable salt thereof, optionally in a pharmaceutically acceptable carrier.
6. The method of claim 5 , wherein the viral disease is selected from the group consisting of human immunodeficiency virus, influenza, herpes simplex virus, human herpes virus, cytomegalovirus, hepatitis B and C virus, Epstein-Barr virus, varicella zoster virus, orthopox virus, ebola virus and papilloma virus.
7. The method of claim 6 , wherein the orthopox is selected from variola major and minor, vaccinia, smallpox, cowpox, camelpox and monkeypox.
8. The method of claim 5 , wherein the virus is HIV.
9. The method of claim 5 , wherein the virus is influenza.
10. The method of claim 5 , wherein the virus is herpes.
11. The method of claim 5 , wherein the virus is cytomegalovirus.
12. The method of claim 5 , wherein the virus is hepatitis B.
13. The method of claim 5 , wherein the virus is hepatitis C.
14. The method of claim 5 , wherein the virus is Epstein-Barr virus.
15. The method of claim 5 , wherein the virus is varicella zoster virus.
16. The method of claim 5 , wherein the virus is papilloma.