Treatment of oral pharyngeal dysphagia
View Patent ↗The invention provides compounds for use in a method of treating oral pharyngeal dysphagia in an individual and related products. One embodiment of the invention comprises administering to an individual an effective amount of a vanilloid receptor 1 (VR-1) agonist or high-affinity partial agonist to promote a swallow reflex.
1. A method for treating oral pharyngeal dysphagia in an individual in need thereof, the method comprising: administering to the individual an effective amount of a product comprising vanilloid receptor 1 (VR-1) agonists capable of promoting a swallow reflex in the individual, the product further comprising a thickening agent, wherein the VR-1 agonist comprises capsaicin and an additional VR-1 agonist selected from the group consisting of capsiate, dihydrocapsiate, nordihydrocapsiate, anandamide and combinations thereof.
2. The method of claim 1 , wherein the thickening agent comprises starch.
3. The method of claim 1 , wherein the individual is suffering from oral pharyngeal dysphagia as a consequence of at least one of the following: cancer chemotherapy, cancer radiotherapy, surgery for oral cancer, surgery for throat cancer, a stroke, a brain injury, and a progressive neuromuscular disease.
4. The method of claim 3 , wherein the progressive neuromuscular disease is Parkinson's Disease.
5. The method of claim 1 , wherein the VR-1 agonists are administered in a non-hydrating beverage.
6. The method of claim 5 , wherein said nonhydrating beverage is a caffeinated beverage.
7. The method of claim 1 , wherein the product is a thickened beverage, the thickening agent selected from the group consisting of starches, gums, cellulose and combinations thereof.
8. The method of claim 1 , wherein said product is a coffee or carbonated beverage.
9. The method of claim 1 , wherein said product is an alcoholic beverage or non-alcoholic simulated beverage.
10. The method of claim 1 , wherein the product is a soup.
11. The method of claim 1 , wherein the product is a yogurt.
12. The method of claim 1 , wherein the product is an ice cream.
13. The method of claim 1 , wherein the product is a medicinal product.
14. The method of claim 13 , wherein the medicinal product is a pharmaceutical.
15. The method of claim 13 , wherein the medicinal product is a nutraceutical.
16. The method of claim 1 , wherein the product is a nutritional supplement.
17. The method of claim 1 , wherein the product is an herbal preparation.
18. The method of claim 1 wherein the product is a vitamin, mineral or vitamin and mineral supplement.
19. The method of claim 1 wherein the product comprises an ingredient in which the VR-1 agonists are dissolved and which is selected from the group consisting of alcohol, fat and oil.