Nutritional composition containing oligosaccharide mixture
View Patent ↗A nutritional composition for administration to an infant which composition comprises, on a dry matter basis, from 2.5 to 15.0 wt % of an oligosaccharide mixture consisting of N-acetylated oligosaccharide(s), galacto-oligosaccharide(s) and sialylated oligosaccharide(s) with the proviso that the composition comprises at least 0.02 wt % of an N-acetylated oligosaccharide, at least 2.0 wt % of a galacto-oligosaccharide and at least 0.04 wt % of a sialylated oligosaccharide and that the N-acetylated oligosaccharide(s) comprise 0.5 to 4.0% of the oligosaccharide mixture, the galacto-oligosaccharide(s) comprise 92.0 to 98.5% of the oligosaccharide mixture and the sialylated oligosaccharide(s) comprise 1.0 to 4.0% of the oligosaccharide mixture. The composition is useful for administration to an infant in the first six months of life to reduce the risk of obesity later in life.
1. A nutritional composition for administration to an infant comprising, on a dry matter basis, from 2.5 to 15.0 wt % of an oligosaccharide mixture consisting of N-acetylated oligosaccharide(s), galacto-oligosaccharide(s) and sialylated oligosaccharide(s) wherein the composition comprises at least 0.02 wt % of an N-acetylated oligosaccharide, at least 2.0 wt % of a galacto-oligosaccharide and at least 0.04 wt % of a sialylated oligosaccharide and wherein the N-acetylated oligosaccharide(s) comprise 0.5 to 4.0% of the oligosaccharide mixture, the galacto-oligosaccharide(s) comprise 92.0 to 98.5% of the oligosaccharide mixture and the sialylated oligosaccharide(s) comprise 1.0 to 4.0% of the oligosaccharide mixture.
2. The composition of claim 1 comprising at least 0.03 wt % of an N-acetylated oligosaccharide, at least 3.0 wt % of a galacto-oligosaccharide and at least 0.08 wt % of a sialylated oligosaccharide.
3. The composition of claim 1 , comprising at least 0.04 wt % of an N-acetylated oligosaccharide, at least 4.0 wt % of a galacto-oligosaccharide and at least 0.09 wt % of a sialylated oligosaccharide.
4. The composition of claim 1 , comprising 3.0 to 12.0% of the oligosaccharide mixture.
5. The composition of claim 1 , comprising 4.0 to 7.0% of the oligosaccharide mixture.
6. The composition of claim 1 , wherein the N-acetylated oligosaccharide is selected from the group consisting of GalNAcα1-3Galβ1-4Glc; Galβ1-6GalNAcα1-3Galβ1-4Glc; and a mixture thereof.
7. The composition of claim 1 , wherein the galacto-oligosaccharide is selected from the group consisting of Galβ1-6Gal; Galβ1-6Galβ1-4Glc; Galβ1-6Galβ1-6Glc; Galβ1-3Galβ1-3Glc; Galβ1-3Galβ1-4Glc; Galβ1-6Galβ1-6Galβ1-4Glc; Galβ1-6Galβ1-3Galβ1-4Glc; Galβ1-3Galβ1-6Galβ1-4Glc; Galβ1-3Galβ1-3Galβ1-4Glc; Galβ1-4Galβ1-4Glc; Galβ1-4Galβ1-4Galβ1-4Glc and mixtures thereof.
8. The composition of claim 1 , wherein the sialylated oligosaccharide is selected from the group consisting of NeuAcα2-3Galβ1-4Glc; NeuAca2-6Galβ1-4Glc; and a mixture thereof.
9. The composition of claim 1 , comprising a probiotic bacterial strain.
10. The composition of claim 9 , wherein the probiotic bacterial strain is selected from the group consisting of Lactobacillus rhamnosus ATCC 53103, Lactobacillus rhamnosus CGMCC 1.3724, Lactobacillus reuteri DSM 17938 , Streptococcus salivarius DSM 13084 and Bifidobacterium lactis CNCM 1-3446.
11. The composition of claim 1 which is an infant formula.