Nutritional composition comprising probiotics and improving sleep patterns
View Patent ↗This invention relates to the use of a probiotic bacterial strain in the manufacture of a medicament or therapeutic nutritional composition for improving the maturation of sleep patterns in infants, young children or young animals and/or for reducing sleep disturbances and/or improving sleep patterns in humans or animals at any age.
1. A method for reducing stress-induced sleep disturbances comprising administering a therapeutically-effective amount of a composition including a probiotic bacterial strain that is Lactobacillus reuteri DSM 17938 to a human or animal having a low level of brain-derived neurotrophic factor (BDNF).
2. The method of claim 1 wherein the human or animal is selected from the group consisting of infants, young animals and young children.
3. The method of claim 1 , wherein the human or animal suffers from poor quality sleep and/or insomnia.
4. The method of claim 1 , wherein the composition induces a mature sleep pattern or reduces the number of episodes of wakefulness in the human or animal.
5. The method of claim 1 , wherein the daily dose of probiotic bacteria is from 10 3 to 10 12 colony forming units (cfu).
6. The method of claim 1 , wherein the composition comprises from 10 3 to 10 12 colony forming units (cfu) of probiotic bacteria per g of composition.
7. The method of claim 1 , wherein the composition is a supplement and the probiotic bacterial strain is present in an amount of from 10 3 to 10 12 cfu per unit dose.
8. The method of claim 1 , wherein the composition is in a form selected from the group consisting of a human milk fortifier, an infant formula, a follow on formula, a growing up milk, an infant cereal, a baby food, a yogurt, a cereal bar, a breakfast cereal, a dessert, a frozen food, a soup, a pet food, a liquid suspension, a powder, a tablet, a gum, a candy, a nutritional composition, and a nutritional supplement.
9. The method of claim 1 , wherein the composition induces a more mature sleep pattern.
10. The method of claim 1 , wherein the composition comprises carbohydrates, and the carbohydrates comprise rice carbohydrates.
11. The method of claim 1 , wherein the composition is a starter infant formula or a follow-up infant formula.
12. A method for improving sleep quality or sleep patterns comprising administering a therapeutically-effective amount of a composition comprising a probiotic bacterial strain that is Lactobacillus reuteri DSM 17938 to a human or animal having a low level of brain-derived neurotrophic factor (BDNF).
13. The method of claim 12 wherein the human or animal is selected from the group consisting of infants, young animals and young children.
14. The method of claim 12 , wherein the human or animal suffers from poor quality sleep and/or insomnia.
15. The method of claim 12 , wherein the composition induces a mature sleep pattern or reduces the number of episodes of wakefulness in the human or animal.
16. The method of claim 12 , wherein the daily dose of probiotic bacteria is from 10 3 to 10 12 colony forming units (cfu).
17. The method of claim 12 , wherein the composition comprises from 10 3 to 10 12 colony forming units (cfu) of probiotic bacteria per g of composition.
18. The method of claim 14 , wherein the poor quality sleep and/or insomnia is stress-induced.
19. The method of claim 12 , wherein the composition is a supplement and the probiotic bacterial strain is present in an amount of from 10 3 to 10 12 cfu per unit dose.
20. The method of claim 12 , wherein the composition is in a form selected from the group consisting of a human milk fortifier, an infant formula, a follow on formula, a growing up milk, an infant cereal, a baby food, a yogurt, a cereal bar, a breakfast cereal, a dessert, a frozen food, a soup, a pet food, a liquid suspension, a powder, a tablet, a gum, a candy, a nutritional composition, and a nutritional supplement.
21. The method of claim 12 , wherein the composition induces a more mature sleep pattern.
22. The method of claim 12 , wherein the composition comprises carbohydrates, and the carbohydrates comprise rice carbohydrates.
23. The method of claim 12 , wherein the composition is a starter infant formula or a follow-up infant formula.
24. A method for reducing stress-induced sleep disturbances comprising administering a therapeutically-effective amount of a composition including a probiotic bacterial strain that is Bifidobacterium longum BAA-999 to a human or animal having a low level of brain-derived neurotrophic factor (BDNF).