MIXED-MODE ADSORBENT MATERIAL
This invention provides an adsorbent material capable of effectively trapping a target component in a sample solution and releasing the same, which has the satisfactory trapping capacity via hydrophobic interactions and via ion exchange reactions. The invention relates to an adsorbent material comprising a porous material of a polymer compound which is a copolymer obtained via copolymerization of a hydrophobic monomer (A), a hydrophilic monomer (B) capable of undergoing a second-order reaction, and a hydrophilic monomer (C) exhibiting a hydrogen-bonding capacity, and via introduction of an ion exchange group into a repeat unit derived from the hydrophilic monomer (B).
1 . An adsorbent material comprising a porous material of a polymer compound which is a copolymer obtained via copolymerization of a hydrophobic monomer (A), a hydrophilic monomer (B) capable of undergoing a second-order reaction, and a hydrophilic monomer (C) exhibiting a hydrogen-bonding capacity, and via introduction of an ion exchange group into a repeat unit derived from the hydrophilic monomer (B).
2 . The adsorbent material according to claim 1 , which comprises an aromatic divinyl compound as the hydrophobic monomer (A) in an amount of at least 50% by mass based on the total amount of monomers.
3 . The adsorbent material according to claim 1 , which comprises glycidyl methacrylate, glycerin methacrylate, 3-chloro-2-hydroxypropyl methacrylate, 2-hydroxyethyl methacrylate, or 2-chloroethyl methacrylate as the hydrophilic monomer (B) capable of undergoing a second-order reaction in an amount of 20% to 50% by mass based on the total amount of monomers.
4 . The adsorbent material according to claim 3 , wherein the hydrophilic monomer (B) capable of undergoing a second-order reaction is glycidyl methacrylate.
5 . The adsorbent material according to claim 1 , which comprises N,N-dimethylacrylamide, N,N-diethylacrylamide, or N-isopropylacrylamide as the hydrophilic monomer (C) exhibiting a hydrogen-bonding capacity in an amount of 5% to 10% by mass based on the total amount of monomers.
6 . The adsorbent material according to claim 1 , wherein the average pore diameter of the porous material is 15 nm to 50 nm and the specific surface area is 100 to 500 m 2 /g.
7 . The adsorbent material according to claim 1 , wherein the porous material has a particulate form and the average particle diameter is 3 μm to 100 μm.
8 . The adsorbent material according to claim 1 , wherein the ion exchange group is a quaternary ammonium group introduced so that the ion exchange group amount is 0.3 to 0.8 meq, a secondary ammonium group introduced so that the ion exchange group amount is 0.7 to 1.5 meq, or a carboxyl group introduced so that the ion exchange group amount is 0.7 to 1.5 meq.
9 . An adsorbent material comprising a porous material having an average pore diameter of 15 nm to 50 nm and a specific surface area of 100 to 500 m 2 /g of a polymer compound which is a copolymer obtained via copolymerization of a hydrophobic monomer (A), a hydrophilic monomer (B) capable of undergoing a second-order reaction, and a hydrophilic monomer (C) exhibiting a hydrogen-bonding capacity, and via introduction of an ion exchange group into a repeat unit derived from the hydrophilic monomer (B).
10 . A solid-phase extraction cartridge comprising the adsorbent material according to claim 1 filled in a container.
11 . The solid-phase extraction cartridge according to claim 10 , which is used for concentration of a target component and/or removal of contaminants.
12 . A method for treating a sample solution comprising performing solid-phase extraction or column switching with the use of the solid-phase extraction cartridge according to claim 10 .
13 . A method for treating a sample solution containing a target component comprising bringing the sample solution containing a target component into contact with the adsorbent material according to claim 1 under conditions in which the target component is adsorbed to the adsorbent material to isolate, separate, fractionate, clean up, or remove the target component.
14 . A method for determining the amount of a target component in a sample solution comprising bringing the sample solution containing a target component into contact with the adsorbent material according to claim 1 under conditions in which the target component is adsorbed to the adsorbent material, washing the adsorbent material to which the target component had adsorbed under conditions in which the target component is released from the adsorbent material, and determining the amount of the target component in the solution resulting from the washing via an analytical technique.
15 . The method according to claim 13 , wherein the adsorbent material is used in the form of a solid-phase extraction cartridge filled in a container.
16 . The method according to claim 13 , wherein the target component is a drug, agricultural chemical, herbicide, biomolecule, poison, contaminant, metabolite, or degraded product of any thereof.
17 . The method according to claim 13 , wherein the sample solution is of blood, blood plasma, urine, spinal fluid, joint fluid, tissue extract, ground water, surface water, drinking water, soil extract, a food material, an extract of a food material, a plant extract, or an extract of a processed food.