Granted Patent
B2
US 8,394,806 · App. 13/183,348 · Granted Mar 12, 2013
2-phenyl pyrazines as tubulin inhibitors
Inventors:
Christopher John Burns (Richmond, AU); Andrew Frederick Wilks (South Yarra, AU); Michael Francis Harte (Viewbank, AU); Harrison Sikanyika (Kilsyth, AU); Emmanuelle Fantino (Elwood, AU)
Assignee:
YM Biosciences Australia Pty Ltd
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Abstract
Compounds of general formula (I), (II), (III) and (V) are described for use in modulating microtubule polymerisation and in the treatment of associated disease states. Use of compounds (I), (III) and (V) in the treatment of kinase-associated disease states is also described. Further described are novel compounds of formula (II), (III) and (V).
Claims (5)
1. A compound selected from the group consisting of:
or pharmaceutically acceptable salts, enantiomers, or diastereomers thereof.
2. A compound of the formula:
or a pharmaceutically acceptable salt, enantiomer or diastereomer thereof.
3. A pharmaceutical composition comprising a carrier and at least one compound according to claim 1 or 2 .
Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST
Recorded Jan 8, 2013
From: BURNS, CHRISTOPHER JOHN; WILKS, ANDREW FREDERICK; HARTE, MICHAEL FRANCIS; SIKANYIKA, HARRISON; FANTINO, EMMANUELLE; SIMS, COLETTE GLORIA
To: CYTOPIA RESEARCH PTY LTD
Reel/Frame 029588/0463 →
CHANGE OF NAME
Recorded Jan 8, 2013
From: CYTOPIA RESEARCH PTY LTD
To: YM BIOSCIENCES AUSTRALIA PTY LTD
Reel/Frame 029588/0527 →
Priority Claims (1)
AU 2003906680
· Dec 3, 2003
· national
Continuity (2)
Division
10581534