Infant feeding formulas comprising probiotic micro-organisms
View Patent ↗The present invention relates to the field of infant nutrition. In particular, the present invention relates to infant feeding formulas comprising probiotic micro-organisms. These probiotic micro-organisms may be non-replicating probiotic micro-organisms such as bioactive heat treated probiotic micro-organisms, for example.
1. An infant feeding formula to be administered to infants as an only nutrition source or as a complementary nutrition source in addition to breastfeeding, to provide complete nutrition to the infant and also comprising non-replicating probiotic micro-organisms rendered non-replicating by a heat treatment at 120 to 140° C. for 5-15 seconds, the non-replicating probiotic micro-organisms selected from the group consisting of Bifidobacterium longum NCC 2705, Bifidobacterium breve NCC 2950, Lactobacillus johnsonii La1 , Lactobacillus reuteri DSM17938, Lactobacillus reuteri ATCC55730, Streptococcus thermophilus NCC 2019, Streptococcus thermophilus NCC 2059, Lactobacillus casei NCC 4006, Lactobacillus acidophilus NCC 3009, Lactobacillus casei ACA-DC 6002 (NCC 1825), Escherichia coli Nissle, Lactobacillus bulgaricus NCC 15, Lactococcus lactis NCC 2287, and combinations thereof, wherein the non-replicating probiotic micro-organisms induce less pro-inflammatory cytokines while maintaining or inducing additional Interleukin 10 (IL-10) production relative to live counterpart.
2. The infant feeding formula in accordance with claim 1 having a caloric density of 62-68 kcal/100 ml, and comprising a protein source in an amount of 1.5-2.8 g/100 kcal, a carbohydrate source in an amount of 10-12 g/100 kcal, and a lipid source in an amount of 5-5.5 g/100 kcal.
3. The infant feeding formula in accordance with claim 1 , comprising 0.2-0.3 g LC-PUFA/100 g fatty acids, wherein the LC-PUFA are a combination of ARA and DHA.
4. The infant feeding formula in accordance with claim 1 , comprising 1.5-2.5 mg nucleotides per 100 mL formula.
5. The infant feeding formula in accordance with claim 1 , comprising the non-replicating probiotic micro-organisms in an amount corresponding to 10 4 to 10 12 cfu.
6. A method for the treatment of inflammatory disorders, the method comprising:
administering to an infant the infant feeding formula of claim 1 .
7. A method for the treatment of disorders related to a compromised immune defense, the method comprising:
administering to an infant the infant feeding formula of claim 1 .
8. The infant feeding formula in accordance with claim 1 further comprising a live counterpart of the non-replicating probiotic micro-organisms.
9. The infant feeding formula in accordance with claim 1 , containing about 0.005 mg-1000 mg of the non: replicating micro-organisms per daily dose.
10. The method in accordance with claim 6 , wherein the infant formula has a caloric density in the range of 62-68 kcal/100 ml and further comprises a protein source in an amount of 1.5-2.8 g/100 kcal, a carbohydrate source in an amount of 10-12 g/100 kcal, and a lipid source in an amount of 5-5.5 g/100 kcal.
11. The method in accordance with claim 6 , wherein the infant formula comprises about 0.005 mg-1000 mg non-replicating micro-organisms per daily dose.
12. The method in accordance with claim 7 , wherein the infant formula has a caloric density in the range of 62-68 kcal/100 ml and further comprises a protein source in an amount of 1.5-2.8 g/100 kcal, a carbohydrate source in an amount of 10-12 g/100 kcal, and a lipid source in an amount of 5-5.5 g/100 kcal.
13. The method in accordance with claim 7 , wherein the infant formula comprises about 0.005 mg-1000 mg non-replicating micro-organisms per daily dose.