Method for treating brain cancer using a novel tumor suppressor gene and secreted factor
View Patent ↗The present invention is directed to methods of using HSS1 (Hematopoietic Signal peptide-containing Secreted 1), HSM1 (Hematopoietic Signal peptide-containing Membrane domain-containing 1), or a combination thereof in the treatment of various cancers, such as brain cancers.
1. A method for treating a brain cancer that is glioblastoma or astrocytoma, comprising administering via intracerebroventricular infusion to the brain of a subject in need of treatment of glioblastoma or astrocytoma an effective amount of Hematopoietic Signal peptide-containing Secreted 1 (HSS1) comprising SEQ ID NO: 6.
2. The method of claim 1 , wherein the brain cancer is a primary brain cancer that is glioblastoma or astrocytoma.
3. The method of claim 1 , wherein the HSS1 is delivered before or after radiation therapy.
4. The method of claim 1 , wherein the HSS1 is delivered before or after brain surgery to remove all or part of the cancerous tissue.
5. The method of claim 1 , wherein the HSS1 is delivered before or after chemotherapy.
6. The method of claim 1 , wherein the subject treated with the HSS1 has increased survival following treatment.
7. The method of claim 1 , wherein treatment with the HSS1 results in a reduction in mass of the glioblastoma or astrocytoma.
8. The method of claim 1 , wherein an effective and safe dose of the HSS1 is administered to the subject in need of treatment of glioblastoma or astrocytoma.
9. A method for treating a brain cancer that is glioblastoma or astrocytoma, comprising administering via intracerebroventricular infusion to the brain of a subject in need of treatment of glioblastoma or astrocytoma an effective amount of a peptide having at least about 95% homology to Hematopoietic Signal peptide-containing Secreted 1 (HSS1) comprising SEQ ID NO: 6.