Scanning probe with twin-nanopore or a-single-nanopore biomolecules

1. A system for sensing molecules, the system comprising:

a twin-nanopore probe comprising a first channel and a second channel;

a first pressure-controlled reservoir connected to the first channel, the first pressure-controlled reservoir configured to generate a positive pressure;

a second pressure-controlled reservoir connected to the second channel, the second pressure-controlled reservoir configured to generate a negative pressure;

a container comprising ionic solvent with the molecules, a tip of the twin-nanopore probe being submerged in the container of the ionic fluid with the molecules;

wherein the first channel, the second channel, the first pressure-controlled reservoir, and the second pressure-controlled reservoir are filed with the ionic fluid;

the first-controlled reservoir configured to drive the ionic fluid out of the first channel and the second pressure-controlled reservoir configured to draw in the ionic fluid mixed with the molecules and the solvent through the second channel; and

the twin-nanopore probe configured to facilitate a flow of ionic current that is measured to differentiate the molecules that flow through the second channel.

2. The system of claim 1 , further comprising a region defined by the positive pressure generated by the first pressure-controlled reservoir and the negative pressure generated by the second pressure-controlled reservoir.

3. The system of claim 2 , wherein the region comprises the molecules to be drawn into the second channel.

4. A system of claim 1 , wherein the first channel comprises an elongated section connected to a first nanopore.

5. A system of claim 4 , wherein the first nanopore is an exit for the positive pressure generated by the first pressure-controlled reservoir.

6. A system of claim 5 , wherein the second channel comprises an elongated section connected to a second nanopore.

7. A system of claim 6 , wherein the second nanopore is an entrance for the negative pressure generated by the second pressure-controlled reservoir.

8. A system of claim 7 , wherein inner surfaces of the second nanopore are coated with an organic layer; and

wherein the organic layer interacts differently with the molecules.

9. A system of claim 1 , further comprising a first electrode in the first pressure-controlled reservoir and a second electrode in the second pressure-controlled reservoir.

10. A system of claim 9 , further comprising a voltage source connected to the first electrode and the second electrode.

11. A system of claim 10 , wherein the voltage source generates the ionic current to measure each of the molecules that flow through the second channel.

12. A system for sensing molecules, the system comprising:

a single-nanopore probe comprising a channel;

a reservoir connected to the channel;

a container comprising ionic fluid with the molecules, a tip of the single-nanopore probe being submerged in the container of the ionic fluid with the molecules;

wherein the channel and the reservoir are filled with the ionic fluid;

a negative pressure generated inside the reservoir and applied to the single-nanopore probe being configured to draw the molecules into the channel; and

the single-nanopore probe configured to facilitate a flow of ionic current that is measured to differentiate the molecules that flow into the channel.

13. The system of claim 12 , further comprising a first electrode in the reservoir and a second electrode in the container.

14. The system of claim 13 , further comprising a voltage source connected to the first electrode and the second electrode.

15. The system of claim 14 , wherein the voltage source generates the ionic current to differentiate the molecules that flow into the channel.