Desferrithiocin polyether analogues

1. A method of reducing oxidative stress in a subject in need of treatment therefor, comprising administering to the subject a therapeutically effective amount of a compound represented by Structural Formula (I):

wherein:

R 1 is —H or an acyl group;

R 2 is —[(CH 2 ) n —O] x —[(CH 2 ) n —O] y —R′;

R 3 , R 4 and R 5 are each independently —H, an alkyl group, or —OR 11 ;

R 6 , R 7 , and R 8 are each independently —H or an alkyl group;

R 9 is —OR 12 or —N(OH)R 13 ;

R 11 is —H, an alkyl group or an acyl group;

R 12 is —H or an alkyl group;

R 13 is an alkyl group;

R 14 is an alkyl group;

R′ is an alkyl group;

m is an integer from 1 to 8;

each n is independently an integer from 1 to 8;

x is an integer from 1 to 8;

y is an integer from 0 to 8; and

Z is —C(O)R 14 or

or a pharmaceutically salt thereof.

2. The method of claim 1 , wherein the compound is represented by structural Formula VI:

or a pharmaceutically acceptable salt thereof.

3. The method of claim 1 , wherein R 9 is —OR 12 ; R 8 is —H or —CH 3 ; R 6 and R 7 are independently —H or —CH 3 ; and R 3 , R 4 , and R 5 are each —H.

4. The method of claim 1 , wherein R 9 is —OR 12 ; R 8 is —H or —CH 3 ; and R 3 , R 4 , R 5 , R 6 , and R 7 are each —H.

5. The method of claim 4 , wherein R 2 is —[(CH 2 ) n —O] x —R′; n is 1 to 4; and x is 1 to 4.

6. The method of claim 1 , wherein the compound is represented by a structural formula selected from one of Structural Formulas (IV)-(IX):

or a pharmaceutically acceptable salt of any of the foregoing.

7. The method of claim 1 , wherein R 9 is —OR 12 .

8. The method of claim 7 , wherein R 8 is —H or —CH 3 .

9. The method of claim 8 , wherein R 6 and R 7 are independently —H or —CH 3 .

10. The method of claim 1 , wherein the compound is represented by structural Formula V:

or a pharmaceutically acceptable salt thereof.