Compounds, compositions and methods useful for cholesterol mobilization
The invention relates to classes of pharmaceutically-active heterocyclic compounds and pharmaceutically acceptable salts, and hydrates thereof, and compositions comprising the same. The invention also relates to methods for treating or preventing a disease or disorder, which comprises administering a therapeutically or prophylactically effective amount a compound described herein.
1. A compound of Formula (I):
or a pharmaceutically acceptable salt thereof, wherein
each of R 1 , R 2 , and R 3 is independently —H, —OH, —NH 2 , —NH(alkyl), —N(alkyl)(alkyl), hydrocarbyl, —O-hydrocarbyl, aryl, —O-aryl, aralkyl, —O-aralkyl, heteroaryl, —O-heteroaryl, heterocyclyl, —O-heterocyclyl, halo, —OCF 3 , —C(O)O(alkyl), —OC(O)(alkyl), —C(O)NH 2 , —C(O)NH(alkyl), —C(O)N(alkyl)(alkyl), —NHC(O)(alkyl), —N(alkyl)C(O)(alkyl), —OC(O)O(alkyl), —OC(O)NH 2 , —OC(O)NH(alkyl), —OC(O)N(alkyl)(alkyl), —CHNH, —CHN(alkyl), or —SO 2 NH 2 ;
R 4 is —OH, —COOH, or —C(O)O(alkyl),
Z 1 is S;
Z 2 is N; and
n is an integer from 1-6.
2. The compound or pharmaceutically acceptable salt of the compound of claim 1 , wherein R 1 is 2-halo.
3. The compound or pharmaceutically acceptable salt of claim 2 , wherein each of R 2 and R 3 is independently —H or alkyl.
4. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt of any of the foregoing.
5. A composition comprising an effective amount of a compound or pharmaceutically acceptable salt of the compound of claim 1 and
a pharmaceutically acceptable vehicle or carrier.
6. The composition of claim 5 , wherein the composition is formulated for oral administration.
7. The composition of claim 5 , wherein the composition is in the form of a tablet or capsule.
8. The composition of claim 5 , wherein the compound or salt thereof is present in an amount of about 1 mg to about 1,000 mg.
9. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
10. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.
11. The compound of claim 1 , wherein the compound is:
or a pharmaceutically acceptable salt thereof.