Mutations in OAS1 genes
Modified amino acid sequences of OAS1 proteins in non-human primates, and genes related thereto, are provided.
1. A method for treating a viral infection caused by influenza virus in a mammalian subject in need thereof comprising providing to the mammalian subject a therapeutically effective amount of a therapeutic composition comprising a polypeptide consisting of the amino acid sequence of SEQ ID NO:1 except for an amino acid substitution or deletion at position 1 , thereby treating the viral infection in the mammalian subject.
2. A method for treating a viral infection caused by influenza virus in a mammalian subject in need thereof comprising providing to the mammalian subject a therapeutically effective amount of a therapeutic composition comprising a polypeptide consisting of the amino acid sequence of SEQ ID NO:1 except the methionine at position 1 is deleted and the amino acid at position 162 is substituted, thereby treating the viral infection in the mammalian subject.
3. A method for treating a viral infection caused by influenza virus in a mammalian subject in need thereof comprising providing to the mammalian subject a therapeutically effective amount of a therapeutic composition comprising a polypeptide consisting of the amino acid sequence of SEQ ID NO:1 except the methionine at position 1 is deleted, the amino acid at position 162 is glycine and the amino acid at position 104 is substituted, thereby treating the viral infection in the mammalian subject.
4. A method for treating a viral infection caused by West Nile virus in a mammalian subject in need thereof comprising providing to the mammalian subject a therapeutically effective amount of a therapeutic composition comprising a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1 except for an amino acid substitution or deletion at position 1 , thereby treating the viral infection in the mammalian subject.
5. A method for treating a viral infection caused by Dengue virus in a mammalian subject in need thereof comprising providing to the mammalian subject a therapeutically effective amount of a therapeutic composition comprising a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1 except for an amino acid substitution or deletion at position 1 , thereby treating the viral infection in the mammalian subject.
6. A method for treating a viral infection caused by Hepatitis C virus in a mammalian subject in need thereof comprising providing to the mammalian subject a therapeutically effective amount of a therapeutic composition comprising a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1 except for an amino acid substitution or deletion at position 1 , thereby treating the viral infection in the mammalian subject.
7. A method for treating a viral infection caused by Respiratory Syncytial Virus (RSV) in a mammalian subject in need thereof comprising providing to the mammalian subject a therapeutically effective amount of a therapeutic composition comprising a polypeptide consisting of the amino acid sequence of SEQ ID NO: 1 except for an amino acid substitution or deletion at position 1 , thereby treating the viral infection in the mammalian subject.