Compositions comprising non-acidic Boswellia oil fraction as a bio-enhancer for enhancing bioavailability of biological agents
The invention relates to a non-acidic Boswellia low polar gum resin extract fraction (BLPRE) in combination with biological agents for enhancing the bioavailability of the biological agents. The invention also provides composition(s) comprising a Boswellia low polar gum resin extract (BLPRE) in combination with a biological agent for increasing the bioavailability of biological agent.
1. A method of enhancing the bioavailability of a biological agent, comprising:
orally administering said biological agent to a subject in combination with an effective amount of a first gum resin extract of a Boswellia species which is substantially free of boswellic acids,
said first gum resin extract of the Boswellia species being:
a water-immiscible organic solvent extract obtained by removing boswellic acids from a Boswellia species gum resin extract; or
a volatile or non-volatile oil obtained by steam distillation of the water-immiscible organic solvent extract; or
a mixture thereof;
wherein said effective amount is effective for enhancing the bioavailability of said biological agent,
wherein the biological agent is a second extract of a Boswellia species, and includes one or more boswellic acids selected from the group consisting of α-boswellic acid, β-boswellic acid, 3-O-acetyl-α-boswellic acid, 3-O-acetyl-β-boswellic acid, 3-O-acetyl-11-keto-β-boswellic acid, and 3-O-acetyl-11-keto-α-boswellic acid.
2. The method of claim 1 , wherein the second extract of a Boswellia species is enriched in 3-O-acetyl-11-keto-β-boswellic acid; and
the biological agent and the first gum resin extract of a Boswellia species are administered in a 2:1 ratio.
3. A method of enhancing the bioavailability of a biological agent, comprising:
orally administering said biological agent to a subject in combination with an effective amount of a first gum resin extract of a Boswellia species which is substantially free of boswellic acids,
said first gum resin extract of the Boswellia species being:
a water-immiscible organic solvent extract obtained by removing boswellic acids from a Boswellia species gum resin extract; or
a volatile or non-volatile oil obtained by steam distillation of the water-immiscible organic solvent extract; or
a mixture thereof;
wherein said effective amount is effective for enhancing the bioavailability of said biological agent,
wherein the biological agent is an extract of a Curcuma species, and includes a curcumin compound selected from the group consisting of curcumin, demethoxycurcumin, bisdemethoxycurcumin, monodemethylcurcumin, bisdemethylcurcumin, tetrahydrocurcumin, tetrahydrodemethoxycurcumin, tetrahydrobisdemethoxycurcumin; and mixtures thereof.
4. The method of claim 3 , wherein the curcumin compound and the first gum resin extract of a Boswellia species are administered in a 2:1 ratio.
5. A method of enhancing the bioavailability of a biological agent, comprising:
orally administering said biological agent to a subject in combination with an effective amount of a gum resin extract of a Boswellia species which is substantially free of boswellic acids,
said gum resin extract of the Boswellia species being:
a water-immiscible organic solvent extract obtained by removing acidic compounds from a Boswellia species gum resin extract; or
a volatile or non-volatile oil obtained by steam distillation of the non-acidic water-immiscible organic solvent extract; or
a mixture thereof;
wherein said effective amount is effective for enhancing the bioavailability of said biological agent;
wherein the biological agent includes at least one of:
one or more boswellic acids selected from the group consisting of α-boswellic acid, β-boswellic acid, 3-O-acetyl-α-boswellic acid, 3-O-acetyl-β-boswellic acid, 3-O-acetyl-11-keto-β-boswellic acid, and 3-O-acetyl-11-keto-α-boswellic acid; and
a component selected from the group consisting of curcumin, demethoxycurcumin, bisdemethoxycurcumin, monodemethylcurcumin, bisdemethylcurcumin, tetrahydrocurcumin, tetrahydrodemethoxycurcumin tetrahydrobisdemethoxycurcumin and mixtures thereof.
6. The method of claim 5 , wherein said Boswellia species is selected from the group consisting of Boswellia serrata, Boswellia carterii, Boswellia papyrifera , and mixtures thereof.
7. The method of claim 5 , wherein said non-acidic gum resin extract is administered in an amount which is effective for enhancing the bioavailability of said biological agent in a warm blooded animal in need thereof.
8. The method of claim 5 , further comprising administering an antioxidant comprising one or more ingredients selected from the group consisting of vitamin A, vitamin C, vitamin E, alpha-carotene, trans-beta-carotene, betacryptoxanthin, lycopene, lutein, zeaxanthin, pine bark bioflavonals complex, germanium, selenium and zinc.
9. The method of claim 5 , further comprising administering a vitamin comprising:
a water-soluble vitamin selected from the group consisting of vitamin B1, vitamin B2, niacinamide, vitamin B6, vitamin B12, folic acid, vitamin C, and mixtures thereof;
a fat-soluble vitamin selected from the group consisting of vitamin A, vitamin D, vitamin E and vitamin K, and mixtures thereof; or
a mixture of said water-soluble vitamin and said fat-soluble vitamin.
10. The method of claim 5 , further comprising administering a mineral comprising one or more minerals selected from the group consisting of calcium, iron, zinc, vanadium, selenium, chromium, iodine, potassium, manganese, copper, and magnesium.
11. The method of claim 5 , further comprising administering an amino acid comprising one or more amino acids selected from the group consisting of lysine, isoleucine, leucine, threonine, valine, tryptophan, phenylalanine, methionine, and 1-selenomethionine.
12. The method of claim 5 , further comprising administering an oil comprising one or more oils selected from the group consisting of omega-3 fatty acids, flaxseed oil, fish oils, essential oils and volatile oils.
13. The method of claim 5 , wherein said Boswellia species is selected from the group consisting of Boswellia ameero, Boswellia bullata, Boswellia dalzielii, Boswellia dioscorides, Boswellia elongata, Boswellia frereana, Boswellia nana, Boswellia neglecta, Boswellia ogadensis, Boswellia pirottae, Boswellia popoviana, Boswellia rivae, Boswellia sacra and Boswellia socotrana .
14. A method of enhancing the bioavailability of a biological agent, comprising:
orally administering said biological agent to a subject in combination with an effective amount of a non-acidic gum resin extract of a Boswellia species,
said non-acidic gum resin extract of the Boswellia species being a water-immiscible organic solvent extract of the gum resin of said Boswellia species;
said water-immiscible organic solvent extract comprising serratol, olean-12-ene-3α-ol, and urs-12-ene-3α-ol, and substantially no boswellic acids;
wherein said effective amount is effective for enhancing the bioavailability of said biological agent;
wherein the biological agent includes at least one of:
one or more boswellic acids selected from the group consisting of α-boswellic acid, β-boswellic acid, 3-O-acetyl-α-boswellic acid, 3-O-acetyl-β-boswellic acid, 3-O-acetyl-11-keto-β-boswellic acid, and 3-O-acetyl-11-keto-α-boswellic acid; and
a component selected from the group consisting of curcumin, demethoxycurcumin, bisdemethoxycurcumin, monodemethylcurcumin, bisdemethylcurcumin, tetrahydrocurcumin, tetrahydrodemethoxycurcumin, tetrahydrobisdemethoxycurcumin and mixtures thereof.