Glycoside compounds and pharmaceutical compositions thereof
The present invention provides glycoside compounds, methods of preparing such compounds, pharmaceutical compositions comprising such compounds, and a method for the treatment of hyperproliferative diseases using the same.
1. A compound of formula I:
or a pharmaceutically acceptable ester, conjugate, hydrate, solvate or salt thereof, wherein:
R is selected from the group consisting of
R a is CH 3 ;
R b is CH 3 , CH 2 OH, or CHO;
R c is H, OH, or CH 3 COO;
R d is H or OH;
R e is H or absent when R f is H, OH or a C═C exists between the atoms joined to R e , R f and R g ;
R f is H, OH, or absent when R e is H or a C═C exists between the atoms joined to R e , R f and R g ;
R g is H or when a C═C exists between the atoms joined to R e , R f and R g , R g is no group;
R h is H or OH;
X is O;
R′ is an alkyl or aryl group; and
Sugar is selected from the group consisting of
and their epimers and conformers.
2. A pharmaceutical composition comprising a compound of claim 1 and at least one pharmaceutically acceptable excipient.
3. The pharmaceutical composition of claim 2 wherein the at least one pharmaceutically acceptable excipient is a cyclodextrin.
4. A method of treating cancer in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a pharmaceutical composition of claim 2 .
5. A method for treating hyperproliferative disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of a compound of claim 1 .
6. The method of claim 4 wherein the cancer is selected from colorectal, non-small cell, lung, ovarian, breast, colon, CNS, liver, lung, and kidney cancers.