Compounds for modulating RNA binding proteins and uses therefor
The invention relates to compositions and methods for inhibiting RNA binding proteins (e.g., MEX-3, MEX-5 and POS-1), as well as methods for treating and preventing disorders associated with parasitic infections and inflammatory disorders.
1. A method for modulating the RNA binding activity of a mammalian homologue of helminth RNA-binding protein MEX-5 in a subject in need thereof, the method comprising administering to said subject an effective amount of compound E:
or a pharmaceutically acceptable salt thereof, such that said RNA binding activity is inhibited.
2. The method of claim 1 , wherein the subject is a human.
3. The method of claim 1 , wherein the RNA mammalian homologue of helminth RNA-binding protein MEX-5 comprises a CCCH zinc finger motif.
4. The method of claim 1 , wherein the mammalian homologue of helminth RNA-binding protein MEX-5 is TTP.