Metalloenzyme inhibitor compounds
The instant invention describes compounds having metalloenzyme modulating activity, and methods of treating diseases, disorders or symptoms thereof mediated by such metalloenzymes.
1. A method of treating a subject suffering from or susceptible to a metalloenzyme-related disorder or disease, comprising administering to the subject an effective amount of a compound of formula (III) or salt thereof:
wherein X is CH, Y is CH, R 2 is alkyl, R 3 is OH, and R 4 and R 5 are independently H, halogen, alkoxy, fluoroalkoxy containing 1-5 fluorines, cyano, carboxamido, optionally substituted aryl, or optionally substituted heteroaryl.
2. The method of claim 1 , wherein the disease or disorder is cancer.
3. The method of claim 1 , wherein the disease or disorder is prostate cancer.
4. The method of claim 1 , wherein the compound of formula (III) is:
1-(6,7-Dimethoxynaphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-4-yl)propan-1-ol (1);
1-(6,7-Bis(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-4-yl)propan-1-ol (3);
2-Methyl-1-(6-(oxazol-5-yl)naphthalen-2-yl)- 1 -(1H-1,2,3-triazol-4-yl)propan-1-ol (4);
2-methyl-1-(1H-1,2,3-triazol-4-yl)-1-(6-(2,2,2-trifluoroethoxy)naphthalen-2-yl)propan-1-ol (12);
1-(6-(difluoromethoxy)naphthalen-2-yl)-2-methyl-1-(1H-1,2,3-triazol-4-yl)propan-1-ol (13);
or salt thereof.
5. The method of claim 4 , wherein the disease or disorder is cancer.
6. The method of claim 4 , wherein the disease or disorder is prostate cancer.