Use of chicoric acid and lactic bacterium in food supplement for regulating skin pigmentation
View Patent ↗The present invention relates generally to the field of cosmetic and/or food supplement. More specifically, the present invention aims to provide the use of at least an ingredient containing chicoric acid and/or derivatives and a micro-organism and/or an enzyme capable of hydrolyzing chicoric acid and/or derivatives thereof to generate tartaric and/or caffeic acid, for improving skin tone and preventing and/or treating hyper-pigmentation of skin and/or skin color imperfections such as age-spots and other skin disorders characterized by abnormal pigments. Also, the present invention aims at providing a skin lightening agent.
1. A cosmetic method for treating and/or reducing the risk of occurrence of skin pigment disorders and/or skin imperfections comprising administering an oral food supplement comprising an ingredient containing chicoric acid and/or derivatives thereof, and a lactic acid bacterium and/or an enzyme capable of hydrolyzing chicoric acid and/or derivatives thereof to generate tartaric and/or caffeic acid to an individual in need of same, wherein derivatives of chicoric acid are of the following formula:
R 1 , R 2 , R 3 and/or R 4 being identical or different from one another, and selected from the group consisting of H; C 1 -C 3 -alkyl; aryl; amino acids; and mono-, di- or oligosaccharides.
2. A method in accordance with claim 1 , wherein the skin disorders are that observed in a group consisting of melasma, freckles, vitiligo, piebaldism, phenylketonuria, and age spots.
3. Method in accordance with claim 1 for improving skin tone and/or skin complexion.
4. A cosmetic method for lightening and/ or whitening skin tone comprising administering an oral food supplement comprising an ingredient containing chicoric acid and/or derivatives thereof, and a lactic acid bacterium and/or an enzyme capable of hydrolyzing chicoric acid and/or derivatives thereof to generate tartaric and/or caffeic acid to an individual in need of same, wherein derivatives of chicoric acid are of the following formula:
R 1 , R 2 , R 3 and/or R 4 being identical or different from one another, and selected from the group consisting of H; C 1 -C 3 -alkyl; aryl; C 1 -C 3 -acyl; amino acids; and mono-, di- or oligosaccharides.
5. Method in accordance with claim 1 , wherein the composition improves hydration of the skin and/or skin barrier function.
6. Method in accordance with claim 1 , wherein the chicoric acid and/or derivatives thereof containing ingredient is a natural food.
7. Method in accordance with claim 1 , wherein the composition comprises an enzyme capable of hydrolyzing chicoric acid to generate tartaric and/or caffeic acid.
8. Method in accordance with claim 1 , wherein the lactic acid bacterium capable of hydrolyzing chicoric acid to generate tartaric and/or caffeic acid is a probiotic lactic acid bacterium having an esterase activity.
9. Method in accordance with claim 1 , wherein the lactic acid bacterium is selected from the group consisting of L. johnsonii, B. longum, and B. lactis.
10. Method in accordance with claim 1 , wherein the composition comprises an effective amount of at least one active agent for improving skin hydration or skin ageing.
11. A method for treating and/or reducing the risk of occurrence of skin pigment disorders and/ or skin imperfections, comprising administering, to an individual, an effective amount of at least an ingredient containing chicoric acid and/or derivatives thereof, and a lactic acid bacterium and/or an enzyme capable of hydrolyzing chicoric acid and/or derivatives thereof to generate tartaric and/or caffeic acid in a food supplement, wherein derivatives of chicoric acid are of the following formula:
R 1 , R 2 , R 3 and/or R 4 being identical or different from one another, and selected from the group consisting of H; C 1 -C 3 -alkyl; aryl; C 1 -C 3 -acyl; amino acids; and mono-, di- or oligosaccharides.
12. Method in accordance with claim 4 , wherein the chicoric acid and/or derivatives thereof containing ingredient is a natural food.
13. Method in accordance with claim 4 , wherein the composition comprises an enzyme capable of hydrolyzing chicoric acid to generate tartaric and/or caffeic acid.
14. Method in accordance with claim 4 , wherein the lactic acid bacterium is selected from the group consisting of L. johnsonii, B. longum, and B. lactis.
15. Method in accordance with claim 11 , wherein the chicoric acid and/or derivatives thereof containing ingredient is a natural food.
16. Method in accordance with claim 11 , wherein the composition comprises an enzyme capable of hydrolyzing chicoric acid to generate tartaric and/or caffeic acid.
17. Method in accordance with claim 11 , wherein the lactic acid bacterium is selected from the group consisting of L. johnsonii, B. longum, and B. lactis.
18. Method in accordance with claim 1 , wherein the lactic acid bacterium is selected from the group consisting of Lactobacillus johnsonii (CNCM I-1225), B. longum BB 536, B. lactis (CNCM I-3446) and B. lactis BB12.
19. Method in accordance with claim 4 , wherein the lactic acid bacterium is selected from the group consisting of Lactobacillus johnsonii (CNCM I-1225), B. longum BB 536, B. lactis (CNCM I-3446) and B. lactis BB12.
20. Method in accordance with claim 11 , wherein the lactic acid bacterium is selected from the group consisting of Lactobacillus johnsonii (CNCM I-1225), B. longum BB 536, B. lactis (CNCM I-3446) and B. lactis BB12.
21. Method in accordance with claim 1 , wherein said food supplement further contains chicory in an amount of 0.1 g/l to 10 g/l.
22. Method in accordance with claim 4 , wherein said food supplement further contains chicory in an amount of 0.1 g/l to 10 g/l.
23. Method in accordance with claim 11 , wherein said food supplement further contains chicory in an amount of 0.1 g/l to 10 g/l.
24. Method in accordance with claim 1 , wherein said food supplement further contains chicory for administration in a daily dose of 0.01 g to 100 g.
25. Method in accordance with claim 4 , wherein said food supplement further contains chicory for administration in a daily dose of 0.01 g to 100 g.
26. Method in accordance with claim 11 , wherein said food supplement further contains chicory for administration in a daily dose of 0.01 g to 100 g.
27. Method in accordance with claim 1 , wherein the oral administration of said food supplement is repeated 2 to 3 times a day, for at least 4 weeks.
28. Method in accordance with claim 4 , wherein the oral administration of said food supplement is repeated 2 to 3 times a day, for at least 4 weeks.
29. Method in accordance with claim 11 , wherein the oral administration of said food supplement is repeated 2 to 3 times a day, for at least 4 weeks.