IP Library Granted Patent US 9,514,358
Granted Patent B2
US 9,514,358 · App. 13/848,436 · Granted Dec 6, 2016

Systems and methods for matching and imaging tissue characteristics

Inventors: Elisa Konofagou (New York, NY); Jean Provost (New York, NY)
Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
G06K9/00536A61B8/08A61B8/485G01S7/52042G01S7/52071A61B5/055A61B6/03A61B6/503A61B6/504A61B8/0891G01S15/8977
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Quick Facts
Patent No.
US 9,514,358
App. No.
13/848,436
Granted
Dec 6, 2016
Kind
B2
Abstract

Systems and methods for matching a characteristic of multiple sectors of a moving tissue to verify an overlap thereof are disclosed herein. In an exemplary method, tissue data for at least a first sector and a second sector of a moving tissue is acquired. A characteristic of at least a portion of the first and second sectors is estimated from the acquired tissue data, and the estimated characteristics are matched to verify whether a portion of the first sector overlaps with a portion of the second sector. Estimating can include estimating a displacement such as an axial displacement and/or lateral displacements. Estimating can further include estimating a strain, a velocity, a strain rate and/or a stiffness or equivalent.

Claims (31)

1. A method for imaging an electromechanical wave propagation through a tissue, comprising:

acquiring tissue data for at least a first sector and a second sector of said tissue, said electromechanical wave propagating through said first and second sectors of said tissue;

estimating a characteristic of at least a portion of said first sector and a characteristic of at least a portion of said second sector from said acquired tissue data;

matching said estimated characteristic of said portion of said first sector with said estimated characteristic of said portion of said second sector;

determining a time delay between said matched characteristic of said portion of said first sector and said matched characteristic of said portion of said second sector; and

forming an image of said electromechanical wave propagating through said portion of said first sector and said portion of said second sector utilizing said determined time delay.

2. The method of claim 1 , wherein said characteristic comprises a displacement.

3. The method of claim 1 , wherein said characteristic comprises a strain.

4. The method of claim 1 , wherein said characteristic comprises velocity.

5. The method of claim 1 , wherein said characteristic comprises a strain rate.

6. The method of claim 1 , wherein said characteristic comprises a stiffness.

7. The method of claim 2 , wherein said displacement comprises axial displacement.

8. The method of claim 2 , wherein said displacement comprises lateral displacement.

9. The method of claim 1 , wherein forming said image comprises forming a one-dimensional image of said electromechanical wave propagating through said tissue.

10. The method of claim 1 , wherein estimating said characteristic further comprises using a speckle-tracking technique.

11. The method of claim 1 , further comprising:

acquiring electrical activity data from said moving tissue; and

determining a correspondence between said electrical activity and said estimated characteristic of said portion of said first sector and said estimated characteristic of said portion of said second sector.

12. A system for imaging an electromechanical wave propagation through a tissue, comprising:

a non-transitory computer readable medium storing program instructions; and

a processor adapted to receive tissue data for at least a first sector and a second sector of said tissue, said electromechanical wave propagating through said first and second sectors of said tissue,

wherein said processor is operatively connected to said non-transitory computer readable medium and configured to execute said stored program instructions,

wherein said processor is further configured such that upon execution of said stored program instructions, said processor:

estimates a characteristic of at least a portion of said first sector and a characteristic of at least a portion of said second sector from said acquired tissue data,

matches said estimated characteristic of said portion of said first sector with said estimated characteristic of said portion of said second sector;

determining a time delay between said matched characteristic of said portion of said first sector and said matched characteristic of said portion of said second sector; and

forming an image of said electromechanical wave propagating through said portion of said first sector and said portion of said second sector utilizing said determined time delay.

13. The system of claim 12 , further comprising a data acquisition device for acquiring data from two or more sectors of said tissue.

14. The system of claim 13 , wherein said data acquisition device comprises an ultrasound device, an MRI device, or a CT device.

15. The system of claim 12 , further comprising an electrical detection device configured to detect an electrical signal propagating through said tissue.

16. The method of claim 1 , wherein forming said image comprises forming a two-dimensional image, a three-dimensional image, or a four-dimensional image of said electromechanical wave propagating through said tissue.

Assignments (1)
CONFIRMATORY LICENSE Recorded May 20, 2013
From: COLUMBIA UNIV NEW YORK MORNINGSIDE
To: NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT
Reel/Frame 030452/0374 →
Continuity (6)
Continuation 13019029 · Feb 1, 2011
Continuation In Part PCTUS2009052563 · Aug 3, 2009
Provisional Application 61085709 · Aug 1, 2008
Provisional Application 61086112 · Aug 4, 2008
Provisional Application 61108470 · Oct 24, 2008
Related Publication 20130315491A1 · Nov 28, 2013