Carnitine granulate and methods for its production
Subject of the invention is a method for the production of a carnitine granulate, which includes the steps of (a) providing an aqueous solution comprising at least 65% (w/w) carnitine, (b) providing a particulate carrier comprising silica, the carrier having an average particle size of more than 150 μm, and (c) mixing the aqueous solution and the carrier. Another subject of the invention is a carnitine granulate.
1. A carnitine granulate, prepared by the process comprising the steps of
(a) providing an aqueous solution comprising at least 65% (w/w) carnitine,
(b) providing a particulate carrier comprising silica, the carrier having an average particle size of more than 150 μm, and
(c) mixing the aqueous solution and the carrier,
whereby a drying step is excluded.
2. The carnitine granulate of claim 1 , wherein the temperature of the aqueous solution is above 60° C.
3. The carnitine granulate of claim 1 , wherein the viscosity of the carnitine solution in step (a) is between 0.5 to 150 mPas.
4. The carnitine granulate of claim 1 , wherein the average particle diameter of the carrier is between 150 and 500 μm.
5. The carnitine granulate of claim 1 , wherein the BET surface of the carrier is between 100 and 1000 m 2 /g.
6. The carnitine granulate of claim 1 , wherein in step (c) the aqueous solution is fed into a mixer containing the carrier whilst the mixer is agitated.
7. The carnitine granulate of claim 1 , wherein an anticaking agent is added.
8. The carnitine granulate of claim 1 , wherein the anticaking agent is hydrophobized silica particles.
9. The carnitine granulate of claim 6 , wherein in step (c) the aqueous solution is fed into the mixer during at least two time intervals, between which the feeding is interrupted whilst agitating the mixture.
10. The carnitine granulate of claim 1 , wherein step (c) comprises the steps of
(c1) feeding a first portion of the aqueous solution into the mixer,
(c2) agitating the mixture for at least 3 minutes whilst no aqueous solution is fed into the mixer,
(c3) feeding a second portion of the aqueous solution into the mixer,
(c4) agitating the mixture for at least 3 minutes whilst no aqueous solution is fed into the mixer,
wherein an anticaking agent is added during or after step (c3) or (c4),
wherein the mixer is agitated during steps (c1) to (c4).
11. A carnitine granulate according to claim 1 having an average particle size of more than 150 μm, wherein the granules essentially consist of a silica carrier coated with carnitine, wherein the granulate optionally comprises an anticaking agent.
12. The carnitine granulate of claim 11 , wherein the carnitine granules comprise 30 to 95% (w/w) silica carrier and 70 to 5% (w/w) carnitine, based on the total amount of solids.
13. A carnitine granulate having an average particle size of more than 150 μm, wherein the carnitine granulate has an angle of repose below 35° and a Hausner ratio of not more than 1.18.
14. The carnitine granulate of claim 13 , wherein the carnitine granules comprise 30 to 95% (w/w) silica carrier and 70 to 5% (w/w) carnitine, based on the total amount of solids.
15. The carnitine granulate of claim 13 , wherein the carnitine granulate comprises an anticaking agent.