Methods for treating osteoarthritis pain by administering a nerve growth factor antagonist and compositions containing the same
The invention concerns anti-NGF antibodies (such as anti-NGF antagonist antibodies), and polynucleotides encoding the same. The invention further concerns use of such antibodies and/or polynucleotides in the treatment and/or prevention of pain, including post-surgical pain, rheumatoid arthritis pain, and osteoarthritis pain.
1. A method for treating osteoarthritis pain comprising administering an effective amount of a monoclonal anti-NGF antagonist antibody to an individual having osteoarthritis, wherein the antibody, in an in vitro assay, (a) blocks the interaction of human NGF with p75 and trkA, (b) specifically binds human NGF with a K D between about 2 pM and about 2 nM, (c) blocks human NGF-dependent neuron survival, and (d) competes with an antibody comprising the amino acid sequences shown in SEQ ID NOS: 1 and 2 for binding to human NGF, thereby ameliorating osteoarthritis pain in said individual.
2. The method of claim 1 , wherein the antibody is administered at a dosing frequency in a range from once every week to once every twelve weeks.
3. The method of claim 1 , wherein the antibody is administered once every month, once every two months, once every three months, once every four months, once every five months, or once every six months.
4. The method of claim 1 , wherein the antibody is administered once every three months.
5. The method of claim 1 , wherein the antibody is administered at a dose in a range from about 3 μg/kg to about 1 mg/kg.
6. The method of claim 1 , wherein the antibody is administered at a dose of about 100 μg/kg.
7. The method of claim 1 , wherein the antibody is administered at a dose of about 300 μg/kg.
8. The method of claim 1 , wherein the antibody is administered intravenously or subcutaneously.
9. The method of claim 1 , wherein the antibody is a humanized antibody or a human antibody.
10. The method of claim 1 , wherein the monoclonal anti-NGF antagonist antibody binds essentially the same epitope as an antibody comprising the amino acid sequences shown in SEQ ID NOS: 1 and 2.
11. The method of claim 1 , wherein the monoclonal anti-NGF antagonist antibody binds to an epitope on human NGF (hNGF), wherein the epitope comprises one or more residues selected from the group consisting of: residues K32, K34, E35, Y79, T81, H84, K88, R103, E11, Y52, L112, S113, R59, R69, V18, V20, and G23.