Heterojunction nanopore for sequencing
A technique is provided for performing sequencing with a nanodevice. Alternating graphene layers and dielectric layers are provided one on top of another to form a multilayer stack of heterojunctions. The dielectric layers include boron nitride, molybdenum disulfide, and/or hafnium disulfide layers. A nanopore is formed through the graphene layers and the dielectric layers. The graphene layers are individually addressed by applying individual voltages to each of the graphene layers on a one to one basis when a particular base of a molecule is in the nanopore. Each of the graphene layers is an electrode. Individual electrical currents are measured for each of the graphene layers as the particular base moves from a first graphene layer through a last graphene layer in the nanopore. The base is identified according to the individual electrical currents repeatedly measured for the base moving from the first through last graphene layer in the nanopore.
1. An apparatus for sequencing, the apparatus comprising:
a nanodevice including:
alternating graphene layers and dielectric layers one on top of another to form a multilayer stack of heterojunctions, wherein the dielectric layers include at least one of boron nitride layers, molybdenum disulfide layers, and hafnium disulfide layers, and wherein the graphene layers include a first graphene layer, a second graphene layer, and a third graphene layer; and
a nanopore through each of the graphene layers and the dielectric layers; and
pairs of electrodes individually addressed to each of the graphene layers, the electrodes applying individual voltages to each of the graphene layers on a one to one basis when a particular base of a molecule is in the nanopore, wherein the first graphene layer is connected to a first pair of electrodes for a first measurement, the second graphene layer is connected to a second pair of electrodes for a second measurement, and the third graphene layer is connected to a third pair of electrodes for a third measurement.
2. The apparatus of claim 1 , further comprising:
a test setup, wherein the test setup is configured to respectively measure individual electrical currents for each of the graphene layers as the particular base moves from a first graphene layer through a last graphene layer in the nanopore; and
wherein the test setup is configured to determine an identification of the particular base according to the individual electrical currents repeatedly measured for the particular base moving from the first graphene layer through the last graphene layer in the nanopore.
3. The apparatus of claim 2 , wherein the test setup is configured such that determining the identification of the particular base according to the individual electrical currents repeatedly measured for the particular base is based on measured values of the individual electrical currents being a same or nearly the same.
4. The apparatus of claim 2 , wherein the test setup is configured such that the individual electrical currents each correspond to the particular base at different locations in the nanopore.
5. The apparatus of claim 2 , wherein the test setup is configured such that the individual electrical currents correspond to measuring via the graphene layers as the electrodes on a one to one basis, such that no graphene layer measures the particular base more than once.
6. The apparatus of claim 2 , wherein the test setup is configured such that a number of the individual electrical currents measured for the particular base at a location of each graphene layer in the nanopore equals a number of the graphene layers.
7. The apparatus of claim 1 , wherein the boron nitride layers each have one or few mono-layers of boron nitride;
wherein each mono-layer of the boron nitride has a thickness of 0.3 nanometers to 0.5 nanometers;
wherein the molybdenum disulfide layers each have one or few mono-layers of molybdenum disulfide; and
wherein each mono-layer of the molybdenum disulfide has a thickness of 0.6 nanometers to 0.8 nanometers.