Treatment of angiogenesis disorders
This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.
1. An antibody, or antigen-binding portion thereof, that binds to IGFBP2, said antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 9 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 10.
2. The antibody, or antigen-binding portion thereof, of claim 1 , wherein the antibody is a monoclonal antibody.
3. A monoclonal antibody, or antigen-binding portion thereof, that binds to IGFBP2, which monoclonal antibody is a humanized version of a first antibody, said first antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 9 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 10, wherein said monoclonal antibody is generated by a method comprising CDR grafting.