IP Library › Granted Patent US 8,980,261
Granted Patent B2
US 8,980,261 · App. 13/984,760 · Granted Mar 17, 2015

Treatment of angiogenesis disorders

Inventors: Sohail Tavazoie (New York, NY); Nils Halberg (Brooklyn, NY); Kim Png (Singapore, SG)
Assignee: The Rockefeller University
A61K38/1709A61K2039/505C07K16/18C07K2317/76C12N15/113C12N15/1135C12N2310/141C12N2320/11C12N2330/31A61K39/3955C12Q1/6886C07K2316/96
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Quick Facts
Patent No.
US 8,980,261
App. No.
13/984,760
Granted
Mar 17, 2015
Kind
B2
Abstract

This invention concerns pathological angiogenesis and cancer, related treatment methods, and related compositions. Also disclosed are related diagnosis kits and methods.

Claims (3)

1. An antibody, or antigen-binding portion thereof, that binds to IGFBP2, said antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 9 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 10.

2. The antibody, or antigen-binding portion thereof, of claim 1 , wherein the antibody is a monoclonal antibody.

3. A monoclonal antibody, or antigen-binding portion thereof, that binds to IGFBP2, which monoclonal antibody is a humanized version of a first antibody, said first antibody comprising a heavy chain variable region comprising the amino acid sequence of SEQ ID NO: 9 and a light chain variable region comprising the amino acid sequence of SEQ ID NO: 10, wherein said monoclonal antibody is generated by a method comprising CDR grafting.

Continuity (2)
Provisional Application 61441738 · Feb 11, 2011
Related Publication 20130330333A1 · Dec 12, 2013