Sn-1(3) monoacylglycerides and lipid absorption
View Patent ↗The present invention relates generally to the field of lipids and in particular aims at improving lipid absorption, for example under conditions of lipid maldigestion or malabsorption. One embodiment of the present invention relates to a composition comprising sn-1(3) monoacylglycerols, wherein the sn-1 or sn-3 position is occupied by an acyl group such as a fatty acid and the sn-2 position remains unoccupied. The fatty acid may be one with anti-inflammatory properties.
1. A method for the treatment of inflammatory disorders, the method comprising administering to a subject suffering from a lipid maldigestion or malabsorption condition a composition comprising a sn-1(3)-monoacylglycerol, wherein the acyl group is a fatty acid having anti-inflammatory properties, the fatty acid selected from the group consisting of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), α-linolenic acid (ALA), stearidonic acid, γ-linolenic acid (GLA), dihomo-γ-linolenic acid (DGLA), n-3 docosapentanenoic acid (DPA), sciadonic acid, juniperonic acid, and combinations thereof.
2. The method of claim 1 , wherein the sn-1(3)-monoacylglycerol is selected from the group consisting of sn-1(3)-monoeicosapentaenoylglycerol, sn-1(3)-mono docosahexaenoylglycerol, sn-1(3)-monooctadecatrienoylglycerol, sn-1(3)-monooctadecatetraenoylglycerol, sn-1(3)-monoeicosatrienoylglycerol, sn-1(3)-mono docosapentaenoylglycerol, sn-1(3)-monosciadonylglycerol, sn-1(3)-monojuniperonylglycerol or combinations thereof.
3. The method claim 1 , wherein the sn-1(3)-monoacylglycerol is sn-1(3)monoeicosapentaenoylglycerol.
4. The method of claim 1 , wherein no more than 25 weight-% of the total monoacylglycerols are sn-2 monoacylglycerols.
5. The method of claim 1 , wherein the composition has a pH of 5-8.
6. The method of claim 1 , wherein the composition is to be stored at 8° C. or below.
7. The method of claim 1 , wherein the composition comprises a lipase B inhibitor.
8. The method of claim 1 , wherein the composition is selected from the group consisting of a food product, an animal food product, a pharmaceutical composition, a nutritional composition, a nutraceutical, a drink, a food additive and a medicament.
9. The method of claim 1 , wherein the composition has a caloric density of 0.5 kcal/ml to 15 kcal/ml.
10. The method of claim 1 , wherein the sn-1(3)-monoacylglycerol derivative provides about 5% to 40% of the energy of the composition.
11. The method of claim 1 , wherein the sn-1(3)-monoacylglycerol derivative provides about 5% to 40% of the energy of the composition.
12. The method of claim 1 , wherein the composition contains a combination of different sn-1(3)-monoacylglycerol derivatives.
13. The method of claim 1 for use in the delivery of fatty acids having anti-inflammatory properties.
14. The method of claim 1 , wherein the malabsorption condition is due to pancreatic insufficiency, bile salt deficiency, a mucosal disorder and/or a short gut.
15. The method of claim 1 , wherein the inflammatory disorder is selected from the group consisting of acute inflammations, chronic inflammations, Crohn's disease, ulcerative colitis, necrotizing enterocolitis, skin inflammation, inflammatory bowel syndrome, liver inflammation, alcoholic cirrhosis, allergy, atopy, bone inflammation, rheumatoid arthritis, systemic lupus, dermato-myositis, thyroiditis, type I diabetes, celiac disease, Biermer's disease, multiple sclerosis, encephalomyelitis, eye inflammation, obesity-associated inflammation, age-related low-grade inflammation, Blau's syndrome, Alzheimer's disease, cardiovascular diseases, atherosclerosis, and metabolic syndrome.