Substituted porphyrins
The present invention relates, in general, to a method of modulating physiological and pathological processes and, in particular, to a method of modulating cellular levels of oxidants and thereby processes in which such oxidants are a participant. The invention also relates to compounds and compositions suitable for use in such methods.
1. A method of treating cardiomyopathy mediated by oxidative stress in a patient in need thereof, said method comprising administering to said patient an effective amount of a compound of formula
or pharmaceutically accept salt thereof,
wherein
R 1 and R 3 are the same and are:
R 2 and R 4 are the same and are:
Y is halogen or —CO 2 X,
each X is the same or different and is an alkyl; and
each R 5 is the same or different and is H or alkyl.
2. The method according to claim 1 , wherein
R 1 and R 3 are
R 2 and R 4 are
Y is —F or —CO 2 X;
X is the same or different and is a C 1-4 alkyl; and
each R 5 is the same or different and is H or C 1-4 alkyl.
3. The method according to claim 1 , wherein R 1 , R 2 , R 3 and R 4 are the same.
4. The method according to claim 3 , wherein
R 1 , R 2 , R 3 and R 4 are
5. The method according to claim 4 , wherein X is methyl or ethyl.
6. The method according to claim 5 , wherein said compound is
7. The method according to claim 1 , wherein said compound is complexed with a metal selected from the group consisting of manganese, iron, copper, cobalt, nickel or zinc.
8. The method according to claim 7 , wherein said compound is complexed with manganese.
9. The method according to claim 8 , wherein said compound is