Antimicrobial compositions and methods of use thereof
The present application discloses a method for treating microbial infection using an antimicrobial composition comprises antimicrobial peptide which contains at least one VGFPV motif.
1. A method of treating a microbial infection of gram positive bacteria, comprising:
administering to a subject in need thereof an effective amount of an antimicrobial peptide comprising an antimicrobial domain comprising the amino acid sequence of SEQ ID NO: 3 or SEQ ID NO: 5.
2. The method of claim 1 , wherein said antimicrobial peptide further comprises a cell penetrating peptide (CPP) domain.
3. The method of claim 1 , wherein said antimicrobial peptide further comprises a targeting domain.
4. The method of claim 1 , wherein said antimicrobial peptide is a PEGylated peptide.
5. A method of treating a microbial infection of gram positive bacteria, comprising:
administering to a subject in need of such treatment an effective amount of an expression vector capable of expressing an antimicrobial peptide comprising the amino acid sequence of SEQ ID NO: 3 or SEQ ID NO: 5.
6. The method of claim 5 , wherein said expression vector is a plasmid expression vector.
7. The method of claim 5 , wherein said expression vector is a viral expression vector.
8. The method of claim 5 , wherein said expression vector is a bacteria phage displaying said antimicrobial peptide on its surface.
9. The method of claim 1 , wherein said antimicrobial peptide comprises the amino acid sequence of SEQ ID NO: 3.
10. The method of claim 1 , wherein said antimicrobial peptide comprises the amino acid sequence of SEQ ID NO: 5.