IMAGING SYSTEMS WITH ACTIVATION MECHANISMS
An imaging system may be used to image a fluid sample containing particles. The imaging system may include a fluid channel that receives the fluid sample and a reactive agent that selectively attaches to target particles in the fluid sample. An activation mechanism may be operated to trigger a chemical reaction between the fluid sample and the reactive agent. The imaging system may include an image sensor integrated circuit and image sensor pixels to capture a detectable effect of the chemical reaction. The image sensor integrated circuit may be synchronized to the activation mechanism such that it captures an image of the fluid sample after the chemical reaction is triggered by the activation mechanism.
1 . An apparatus, comprising:
an image sensor integrated circuit containing image sensor pixels;
a fluid channel over the image sensor integrated circuit, wherein the fluid channel is configured to receive a fluid sample and a reactive agent that selectively attaches to target particles in the fluid sample;
an activation mechanism configured to activate a chemical reaction between the target particles and the reactive agent, wherein the image sensor integrated circuit is configured to perform an image capture operation of an effect of the chemical reaction using the image sensor pixels; and
control circuitry to operate the image sensor integrated circuit and the activation mechanism.
2 . The apparatus defined in claim 1 , wherein the activation mechanism comprises a light pulse.
3 . The apparatus defined in claim 1 , wherein the activation mechanism comprises an activation mechanism selected from the group consisting of: a heat pulse, a pressure pulse, an electric field, and a magnetic field.
4 . The apparatus defined in claim 1 , wherein the image sensor integrated circuit is configured to capture an image indicating photons produced by the chemical reaction.
5 . The apparatus defined in claim 1 , wherein the control circuitry is configured to synchronize the image capture operation of the image sensor integrated circuit with the operation of the activation mechanism such that the image capture operation occurs after the operation of the activation mechanism.
6 . The apparatus defined in claim 1 , wherein the control circuitry is configured to operate the activation mechanism at predetermined regular time intervals.
7 . The apparatus defined in claim 1 , wherein the control circuitry is configured to operate the image capture operation of the image sensor integrated circuit continuously.
8 . The apparatus defined in claim 1 , wherein the control circuitry is configured to operate the image capture operation of the image sensor integrated circuit independent from the operation of the activation mechanism.
9 . The apparatus defined in claim 1 , wherein the control circuitry is configured to operate the image capture operation of the image sensor integrated circuit at predetermined regular time intervals.
10 . The apparatus defined in claim 1 , wherein the reactive agent comprises an enzyme molecule.
11 . A method for imaging a sample with an imaging system having a channel, comprising:
flowing a sample through the channel, wherein the sample includes target particles;
flowing a reactive agent through the channel, wherein the reactive agent binds selectively to the target particles in the sample;
triggering a chemical reaction between the reactive agent and the target particles; and
capturing an image of the sample.
12 . The method defined in claim 11 wherein triggering the chemical reaction between the reactive agent and the target particles comprises operating an activation mechanism in the imaging system.
13 . The method defined in claim 12 , wherein operating the activation mechanism comprises applying a light pulse to the reactive agent and the target particles.
14 . The method defined in claim 12 , wherein operating the activation mechanism comprises applying a heat pulse to the reactive agent and the target particles.
15 . The method defined in claim 11 , wherein capturing the image of the sample comprises capturing the image continuously.
16 . The method defined in claim 11 , wherein capturing an image of the sample comprises capturing the image after triggering the chemical reaction.
17 . The method defined in claim 11 , wherein capturing an image of the sample comprises capturing the image at predetermined regular time intervals.
18 . A system, comprising:
a central processing unit;
memory;
input-output circuitry; and
an imaging sensor integrated circuit having a pixel array;
a channel over the pixel array that is configured to receive a sample containing target particles and reactive agents that selectively attach to the target particles; and
an activation mechanism that is configured to trigger a chemical reaction between the target particles and the reactive agents.
19 . The system defined in claim 18 wherein the activation mechanism enables a rolling shutter capture of the sample.
20 . The system defined in claim 18 wherein the activation mechanism comprises a heat pulse.
21 . The system defined in claim 18 wherein the activation mechanism enables a global shutter capture of the sample.