IP Library Granted Patent US 11,077,229
Granted Patent B1
US 11,077,229 · App. 14/202,448 · Granted Aug 3, 2021

Implant coating composition and method of use

Inventor: Timothy R. Brahm (Germantown, TN)
Assignee: BioDLogics, LLC
A61L27/3604
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Quick Facts
Patent No.
US 11,077,229
App. No.
14/202,448
Granted
Aug 3, 2021
Kind
B1
Abstract

Methods of reducing or preventing an adverse response to an implanted or inserted material in a patient are provided. The methods include the step of treating at least a portion of an external surface of the implanted or inserted material with an effective amount of a birth tissue material coating corn position.

Claims (14)

1. A method of reducing or preventing an adverse response to an implant material in a patient, comprising:

treating at least a portion of an external surface of the implant material prior to implantation or insertion with an effective amount of a birth tissue material coating composition, the coating composition comprising:

(i) a tissue suspension comprising

one or more cryopreserved and morselized placental components selected from the group consisting of morselized placental globe, morselized chorionic membrane, morselized amniotic membrane, or a combination thereof; and

a tissue suspension solution comprising about 0.01% to about 10% volume of dimethyl sulfoxide, and one or more of sodium chloride, glycerol, and methylcellulose; and

(ii) an amniotic fluid composition comprising a cell suspension solution, the cell suspension solution comprising one or more cells isolated from amniotic fluid and human albumin 25% solution.

2. The method of claim 1 , wherein the implant material is selected from the group consisting of medical device, medical implant, graft, and any combinations thereof.

3. The method of claim 2 , wherein the medical implant is a breast implant.

4. The method of claim 1 , wherein the adverse response comprises thrombogenesis, adhesion to surrounding tissue, pain, inflammation, infection, necrosis, edema, allergic foreign body response, implant-induced coagulation, or a combination thereof.

5. The method of claim 1 , wherein the adverse response is acute or chronic rejection.

6. The method of claim 5 , wherein the acute or chronic rejection is capsular contracture.

7. The method of claim 1 , wherein the birth tissue material coating composition is formulated as a liquid or emulsion.

8. The method of claim 1 , wherein the birth tissue material coating composition further comprises a carrier composition.

9. The method of claim 1 , wherein the birth tissue material coating composition is formulated as a solid or semi-solid.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 19, 2016
From: BRAHM, TIMOTHY R
To: BIODLOGICS, LLC
Reel/Frame 038312/0247 →
Continuity (1)
Provisional Application 61774907 · Mar 8, 2013
Cited By (1)
US 12,551,509