Analyte sensing biointerface
Disclosed herein is an analyte sensing biointerface that comprises a sensing electrode incorporated within a non-conductive matrix comprising a plurality of passageways extending through the matrix to the sensing electrode. Also disclosed herein are methods of manufacturing a sensing biointerface and methods of detecting an analyte within tissue of a host using an analyte sensing biointerface.
1. A transcutaneous continuous glucose sensor system, comprising:
a substantially planar sensor, the sensor comprising:
a first non-conductive layer;
a first conductive layer comprising a first electrode, wherein the first conductive layer is disposed over the first non-conductive layer;
a second non-conductive layer disposed over the first conductive layer;
a second conductive layer comprising a second electrode, wherein the second conductive layer is disposed over the second non-conductive layer;
a third non-conductive layer disposed over the second conductive layer;
a third conductive layer comprising a third electrode, wherein the third conductive layer is disposed over the third non-conductive layer;
wherein at least one of the first electrode, second electrode, or third electrode is a working electrode configured to measure a signal indicative of a glucose concentration;
a membrane disposed on at least a portion of the sensor; and
electronics electrically coupled to the working electrode.
2. The sensor of claim 1 , wherein the membrane comprises an enzyme.
3. The sensor of claim 2 , wherein the membrane further comprises a resistance domain disposed over the enzyme.
4. The sensor of claim 1 , wherein the membrane further comprises a bioactive agent.
5. The sensor of claim 1 , wherein the membrane is substantially planar.